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Review of Efficacy and Comparison of Intracameral Antibiotics for Postcataract Surgery Endophthalmitis Prophylaxis

  • Cataract (CE Starr and A Brissette, Section Editors)
  • Published:
Current Ophthalmology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Justify universal adoption of intracameral antibiotic for prophylaxis against postcataract endophthalmitis.

Recent Findings

Review of both placebo-controlled randomized clinical trials for intracameral cefuroxime and moxifloxacin as well as large retrospective studies demonstrate efficacy in reducing the risk of postcataract endophthalmitis when the intracameral antibiotic choice is targeted to the causative pathogens of the demographic studied.

Summary

Clinical evidence demonstrates the benefit of intracameral antibiotic use from statistical, clinical, and cost-effective analyses. Cases with higher risk for endophthalmitis such as posterior capsule rupture, manual extracapsular cataract extraction, immunocompromised patients, and age > 85, warrant special attention and greater consideration for intracameral antibiotic use. Further research to identify the optimal drug, formulation, and concentration can improve patient outcomes.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. NYU School of Medicine, NYU Langone, 222E 41st 4th floor, New York, NY, 10017, USA

    Elizabeth T. Viriya

  2. Scripps Clinic, La Jolla, USA

    Francis S. Mah

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  1. Elizabeth T. Viriya
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  2. Francis S. Mah
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Correspondence to Elizabeth T. Viriya.

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Dr. Mah reports “Other”/“Consultant” from B&L, Novartis, and Allergan, “Other”/“Medical Advisory Board” from Ocular Science and “Other”/Scientific Advisory Board from Polyactiva, outside the submitted work; Dr. Mah has nothing else to disclose. Dr. Viriya has nothing to disclose.

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Viriya, E.T., Mah, F.S. Review of Efficacy and Comparison of Intracameral Antibiotics for Postcataract Surgery Endophthalmitis Prophylaxis. Curr Ophthalmol Rep 7, 241–249 (2019). https://doi.org/10.1007/s40135-019-00224-x

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