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Metal–polymer-coordinated complexes as potential nanovehicles for drug delivery

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Abstract

Hybrid metal–polymer-coordinated complex, as a class of supramolecular coordinated complex, represents a great opportunity for the development of the multipurpose intelligent system of nanomedicine in drug delivery. These structures and their interesting functions are created after the self-assembly process and coordination bond formation between different metal ions and polymers. There is an important difference between metal–organic framework (MOF) and metal–polymer-coordinated complex (MPC). MPCs are convergent structures made of metal and polymeric linkers’ combination in 1D, 2D and 3D architectures while MOFs are divergent 3D network structures with metal cores and organic ligands linkers. Until now, many reviews have been published about MOF-based systems while there is no comprehensive review on MPCs. Moreover, the MPCs have exhibited potential nano-chemistry properties to be utilized in nanomedicine applications as smart and multifunction nanovesicles for drug delivery. In this review, the MPC architectures, their synthesis process and their applications in drug delivery are described. The advantages and disadvantages of MPC are summarized. We also categorized smart MPCs for on-demand drug release and intelligent delivery.

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Fig. 1
Scheme 1.
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Fig. 3

Reproduced from [18] with permission from John Wiley and Sons, Copyright © 2018 and b X-ray crystallography for double helicate chemical structure. Reproduced from [20] with permission, Copyright © 2018

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Reproduced from [29] with permission from Royal Society of Chemistry (Great Britain), Copyright © 2010

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Reproduced from [31] with permission from John Wiley and Sons, Copyright © 2012

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Reproduced from [46] with permission from Royal Society of Chemistry (Great Britain), Copyright © 2020

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reproduced from [47] with permission from Royal Society of Chemistry (Great Britain), Copyright © 2020

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Copyright © 2017

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Reproduced from [57] with permission from American Chemical Society, Copyright © 2012

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Reproduced from [58] with permission from John Wiley and Sons, Copyright © 2018

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Reproduced from [65] with permission from Elsevier, Copyright © 2016

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Reproduced from [68] with permission from Royal Society of Chemistry (Great Britain) Copyright © 2012

Fig. 14

Reproduced from [9] with permission from Royal Society of Chemistry (Great Britain) Copyright © 2020

Fig. 15

Reproduced from [74] with permission from John Wiley and Sons, Copyright © 2011 and b metal-cage structure of MPC. Reproduced from [75] with permission from Royal Society of Chemistry (Great Britain), Copyright © 2010

Fig. 16

Reproduced from [78] with permission from John Wiley and Sons, Copyright © 2015

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Reproduced from [81] with permission from Elsevier, Copyright © 2016

Fig. 19

Reproduced from [69] with permission from Elsevier Copyright © 2017

Fig. 20

Reproduced from [67] with permission from Elsevier, Copyright © 2018

Fig. 21

Reproduced from [88] with permission from Royal Society of Chemistry (Great Britain), Copyright © 2016 and b temperature-responsiveness of Eu-based polymer complex. Reproduced from [103] with permission from Royal Society of Chemistry (Great Britain), Copyright © 2013

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Copyright © 2020

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Acknowledgements

The authors are grateful for the Mashhad University of Medical Sciences (980838).

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Authors and Affiliations

  1. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Hamed Tabasi, Maryam Babaei, Khalil Abnous, Mohammad Ramezani & Mona Alibolandi

  2. Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Hamed Tabasi, Mohammad Ramezani & Mona Alibolandi

  3. Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Seyed Mohammad Taghdisi

  4. Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

    Amir Sh. Saljooghi

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  1. Hamed Tabasi
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  2. Maryam Babaei
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  3. Khalil Abnous
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  4. Seyed Mohammad Taghdisi
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  6. Mohammad Ramezani
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Correspondence to Mohammad Ramezani or Mona Alibolandi.

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Tabasi, H., Babaei, M., Abnous, K. et al. Metal–polymer-coordinated complexes as potential nanovehicles for drug delivery. J Nanostruct Chem 11, 501–526 (2021). https://doi.org/10.1007/s40097-021-00432-7

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  • DOI: https://doi.org/10.1007/s40097-021-00432-7

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