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A mini-review of the diffusion dynamics of DNA-binding proteins: experiments and models

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Abstract

In the course of various biological processes, specific DNA-binding proteins must efficiently find a particular target sequence/protein or a damaged site on the DNA. DNA-binding proteins perform this task based on diffusion. Nevertheless, investigations over recent decades have found that the diffusion dynamics of DNA-binding proteins are generally complicated and, further, protein specific. In this review, we collect experimental and theoretical studies that quantify the diffusion dynamics of DNA-binding proteins and review them from the viewpoint of diffusion processes.

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References

  1. A.D. Riggs, S. Bourgeois, M. Cohn, J. Mol. Biol. 53, 401 (1970)

    Article  Google Scholar 

  2. O.G. Berg, R.B. Winter, P.H. Von Hippel, Biochemistry 20, 6929 (1981)

    Article  Google Scholar 

  3. S.E. Halford, J.F. Marko, Nucl. Acids Res. 32, 3040 (2004)

    Article  Google Scholar 

  4. A.B. Kolomeisky, Phys. Chem. Chem. Phys. 13, 2088 (2011)

    Article  Google Scholar 

  5. H. Kabata, O. Kurosawa, I. Arai, M. Washizu, S.A. Margarson, R.E. Glass, N. Shimamoto, Science 262, 1561 (1993)

    Article  ADS  Google Scholar 

  6. M. Barbi, C. Place, V. Popkov, M. Salerno, Phys. Rev. E 70, 041901 (2004a)

    Article  ADS  Google Scholar 

  7. M. Barbi, C. Place, V. Popkov, M. Salerno, J. Biol. Phys. 30, 203 (2004b)

    Article  Google Scholar 

  8. M. Slutsky, L.A. Mirny, Biophys. J. 87, 4021 (2004)

    Article  ADS  Google Scholar 

  9. L. Mirny, M. Slutsky, Z. Wunderlich, A. Tafvizi, J. Leith, A. Kosmrlj, J. Phys. A 42, 434013 (2009)

    Article  MathSciNet  ADS  Google Scholar 

  10. M. Bauer, R. Metzler, PLoS One 8, e53956 (2013)

    Article  ADS  Google Scholar 

  11. O. Pulkkinen, R. Metzler, Phys. Rev. Lett. 110, 198101 (2013)

    Article  ADS  Google Scholar 

  12. M. Bauer, E.S. Rasmussen, M.A. Lomholt, R. Metzler, Sci. Rep. 5, 10072 (2015)

    Article  ADS  Google Scholar 

  13. J. Gorman, E.C. Greene, Nat. Struct. Mol. Biol. 15, 768 (2008)

    Article  Google Scholar 

  14. A. Tafvizi, F. Huang, J.S. Leith, A.R. Fersht, L.A. Mirny, A.M. van Oijen, Biophys. J. 95, L01 (2008)

    Article  Google Scholar 

  15. A. Tafvizi, F. Huang, A.R. Fersht, L.A. Mirny, A.M. van Oijen, Proc. Natl. Acad. Sci. U.S.A. 108, 563 (2011)

    Article  ADS  Google Scholar 

  16. J.S. Leith, A. Tafvizi, F. Huang, W.E. Uspal, P.S. Doyle, A.R. Fersht, L.A. Mirny, A.M. van Oijen, Proc. Natl. Acad. Sci. U.S.A. 109, 16552 (2012)

    Article  ADS  Google Scholar 

  17. A. Murata, Y. Ito, R. Kashima, S. Kanbayashi, K. Nanatani, C. Igarashi, M. Okumura, K. Inaba, T. Tokino, S. Takahashi, K. Kamagata, J. Mol. Biol. 427, 2663 (2015)

    Article  Google Scholar 

  18. Y. Itoh, A. Murata, S. Sakamoto, K. Nanatani, T. Wada, S. Takahashi, K. Kamagata, J. Mol. Biol. 428, 2916 (2016)

    Article  Google Scholar 

  19. A. Murata, Y. Itoh, E. Mano, S. Kanbayashi, C. Igarashi, H. Takahashi, S. Takahashi, K. Kamagata, Biophys. J. 112, 2301 (2017)

    Article  ADS  Google Scholar 

  20. D.R.G. Subekti, A. Murata, Y. Itoh, S. Fukuchi, H. Takahashi, S. Kanbayashi, S. Takahashi, K. Kamagata, Biochemistry 56, 4134 (2017)

    Article  Google Scholar 

  21. M. Kong, L. Liu, X. Chen, K. Driscoll, P. Mao, S. Böhm, N. Kad, S. Watkins, K. Bernstein, J. Wyrick, J.H. Min, B. Van Houten, Mol. Cell 64, 376 (2016)

    Article  Google Scholar 

  22. N.Y. Cheon, H.S. Kim, J.E. Yeo, O.D. Schärer, J.Y. Lee, Nucl. Acids Res. 47, 8337 (2019)

    Article  Google Scholar 

  23. A. Granéli, C.C. Yeykal, R.B. Robertson, E.C. Greene, Proc. Natl. Acad. Sci. U.S.A. 103, 1221 (2006)

    Article  ADS  Google Scholar 

  24. J.H. Kim, R.G. Larson, Nucl. Acids Res. 35, 3848 (2007)

    Article  Google Scholar 

  25. I. Bonnet, A. Biebricher, P.L. Porté, C. Loverdo, O. Bénichou, R. Voituriez, C. Escudé, W. Wende, A. Pingoud, P. Desbiolles, Nucl. Acids Res. 36, 4118 (2008)

    Article  Google Scholar 

  26. A. Biebricher, W. Wende, C. Escudé, A. Pingoud, P. Desbiolles, Biophys. J. 96, L50 (2009)

    Article  Google Scholar 

  27. J. Dikić, C. Menges, S. Clarke, M. Kokkinidis, A. Pingoud, W. Wende, P. Desbiolles, Nucl. Acids Res. 40, 4064 (2012)

    Article  Google Scholar 

  28. A.R. Dunn, N.M. Kad, S.R. Nelson, D.M. Warshaw, S.S. Wallace, Nucl. Acids Res. 39, 7487 (2011)

    Article  Google Scholar 

  29. S.R. Nelson, A.R. Dunn, S.D. Kathe, D.M. Warshaw, S.S. Wallace, Proc. Natl. Acad. Sci. U.S.A. 111, E2091 (2014)

    ADS  Google Scholar 

  30. P.C. Blainey, A.M. van Oijen, A. Banerjee, G.L. Verdine, X.S. Xie, Proc. Natl. Acad. Sci. U.S.A. 103, 5752 (2006)

    Article  ADS  Google Scholar 

  31. C.L. Vestergaard, P.C. Blainey, H. Flyvbjerg, Nucl. Acids Res. 46, 2446 (2018)

    Article  Google Scholar 

  32. Y.M. Wang, R.H. Austin, E.C. Cox, Phys. Rev. Lett. 97, 048302 (2006)

    Article  ADS  Google Scholar 

  33. E. Marklund, B. van Oosten, G. Mao, E. Amselem, K. Kipper, A. Sabantsev, A. Emmerich, D. Globisch, X. Zheng, L.C. Lehmann, O.G. Berg, M. Johansson, J. Elf, S. Deindl, Nature 583, 858 (2020)

    Article  ADS  Google Scholar 

  34. J. Gorman, A. Chowdhury, J.A. Surtees, J. Shimada, D.R. Reichman, E. Alani, E.C. Greene, Mol. Cell 28, 359 (2007)

    Article  Google Scholar 

  35. J. Gorman, A.J. Plys, M.L. Visnapuu, E. Alani, E.C. Greene, Nat. Struct. Mol. Biol. 17, 932 (2010)

    Article  Google Scholar 

  36. M.W. Brown, Y. Kim, G.M. Williams, J.D. Huck, J.A. Surtees, I.J. Finkelstein, Nat. Commun. 7, 10607 (2016)

    Article  ADS  Google Scholar 

  37. K. Kamagata, E. Mano, K. Ouchi, S. Kanbayashi, R.C. Johnson, J. Mol. Biol. 430, 655 (2018)

    Article  Google Scholar 

  38. F. Wang, S. Redding, I.J. Finkelstein, J. Gorman, D.R. Reichman, E.C. Greene, Nat. Struct. Mol. Biol. 20, 174 (2013)

    Article  Google Scholar 

  39. J. Lin, P. Countryman, N. Buncher, P. Kaur, L.E.Y. Zhang, G. Gibson, C. You, S.C. Watkins, J. Piehler, P.L. Opresko, N.M. Kad, H. Wang, Nucl. Acids Res. 42, 2493 (2014)

    Article  Google Scholar 

  40. J. Lin, P. Countryman, H. Chen, H. Pan, Y. Fan, Y. Jiang, P. Kaur, W. Miao, G. Gurgel, C. You, J. Piehler, N.M. Kad, R. Riehn, P.L. Opresko, S. Smith, Y.J. Tao, H. Wang, Nucl. Acids Res. 44, 6363 (2016)

    Article  Google Scholar 

  41. W.K. Cho, C. Jeong, D. Kim, M. Chang, K.M. Song, J. Hanne, C. Ban, R. Fishel, J.B. Lee, Structure 20, 1264 (2012)

    Article  Google Scholar 

  42. C. Jeong, W.K. Cho, K.M. Song, C. Cook, T.Y. Yoon, C. Ban, R. Fishel, J.B. Lee, Nat. Struct. Mol. Biol. 18, 379 (2011)

    Article  Google Scholar 

  43. N.M. Kad, H. Wang, G.G. Kennedy, D.M. Warshaw, B. Van Houten, Mol. Cell 37, 702 (2010)

    Article  Google Scholar 

  44. H. Ghodke, H. Wang, C.L. Hsieh, S. Woldemeskel, S.C. Watkins, V. RapićOtrin, B. Van Houten, Proc. Natl. Acad. Sci. U.S.A. 111, E1862 (2014)

    Article  Google Scholar 

  45. C.D. Hughes, H. Wang, H. Ghodke, M. Simons, A. Towheed, Y. Peng, B. Van Houten, N.M. Kad, Nucl. Acids Res. 41, 4901 (2013)

    Article  Google Scholar 

  46. L. Liu, M. Kong, N.R. Gassman, B.D. Freudenthal, R. Prasad, S. Zhen, S.C. Watkins, S.H. Wilson, B. Van Houten, Nucl. Acids Res. 45, 12834 (2017)

    Article  Google Scholar 

  47. L. Cuculis, Z. Abil, H. Zhao, C.M. Schroeder, Nat. Chem. Biol. 12, 831 (2016)

    Article  Google Scholar 

  48. L. Cuculis, Z. Abil, H. Zhao, C.M. Schroeder, Nat. Commun. 6, 7277 (2015)

    Article  ADS  Google Scholar 

  49. P.H. Richter, M. Eigen, Biophys. Chem. 2, 255 (1974)

    Article  Google Scholar 

  50. O.G. Berg, C. Blomberg, Biophys. Chem. 4, 367 (1976)

    Article  Google Scholar 

  51. P.H. von Hippel, Science 305, 350 (2004)

    Article  Google Scholar 

  52. V. Dahirel, F. Paillusson, M. Jardat, M. Barbi, J.M. Victor, Phys. Rev. Lett. 102, 228101 (2009)

    Article  ADS  Google Scholar 

  53. B. Bagchi, P.C. Blainey, X.S. Xie, J. Phys. Chem. B 112, 6282 (2008)

    Article  Google Scholar 

  54. P.C. Blainey, G. Luo, S.C. Kou, W.F. Mangel, G.L. Verdine, B. Bagchi, X.S. Xie, Nat. Struct. Mol. Biol. 16, 1224 (2009)

    Article  Google Scholar 

  55. R. Zwanzig, Proc. Natl. Acad. Sci. U.S.A. 85, 2029 (1988)

    Article  ADS  Google Scholar 

  56. I. Goychuk, V.O. Kharchenko, Phys. Rev. Lett. 113, 100601 (2014)

    Article  ADS  Google Scholar 

  57. I. Goychuk, Phys. Chem. Chem. Phys. 20, 24140 (2018)

    Article  Google Scholar 

  58. S. Banerjee, R. Biswas, K. Seki, B. Bagchi, J. Chem. Phys. 141, 124105 (2014)

    Article  ADS  Google Scholar 

  59. T. Terakawa, H. Kenzaki, S. Takada, J. Am. Chem. Soc. 134, 14555 (2012)

    Article  Google Scholar 

  60. Y.M. Wang, R.H. Austin, Single-molecule imaging of LacI diffusing along nonspecific DNA. In Biophysics of DNA-Protein Interactions From Single Molecules to Biological Systems (Springer, New York, 2011), ed. by M.C. Williams, J.L. Maher, pp. 9–38

  61. Y.G. Sinai, Theory Probab. Appl. 27, 256 (1983)

    Article  Google Scholar 

  62. R.J. Ober, A. Tahmasbi, S. Ram, Z. Lin, E.S. Ward, IEEE Signal Process. Mag. 32, 58 (2015)

    Article  ADS  Google Scholar 

  63. M. Hedglin, P.J. O’Brien, ACS Chem. Biol. 5, 427 (2010)

    Article  Google Scholar 

  64. A. Pluciennik, P. Modrich, Proc. Natl. Acad. Sci. U.S.A. 104, 12709 (2007)

    Article  ADS  Google Scholar 

  65. S. Halford, Biochem. Soc. Trans. 37, 343 (2009)

    Article  Google Scholar 

  66. R.H. Porecha, J.T. Stivers, Proc. Natl. Acad. Sci. U.S.A. 105, 10791 (2008)

    Article  ADS  Google Scholar 

  67. M.A. Lomholt, B. van den Broek, S.M.J. Kalisch, G.J.L. Wuite, R. Metzler, Proc. Natl. Acad. Sci. U.S.A. 106, 8204 (2009)

    Article  ADS  Google Scholar 

  68. M.V. Smoluchowski, Z Phys. Chem. 92U, 129 (1918)

    Article  Google Scholar 

  69. J. Haus, K.W. Kehr, Phys. Rep. 150, 263 (1987)

    Article  ADS  Google Scholar 

  70. J.P. Bouchaud, A. Georges, Phys. Rep. 195, 127 (1990)

    Article  MathSciNet  ADS  Google Scholar 

  71. R. Metzler, J. Klafter, Phys. Rep. 339, 1 (2000)

    Article  ADS  Google Scholar 

  72. A.G. Cherstvy, A.V. Chechkin, R. Metzler, New J. Phys. 15, 083039 (2013)

    Article  MathSciNet  ADS  Google Scholar 

  73. W. Wang, A.G. Cherstvy, A.V. Chechkin, S. Thapa, F. Seno, X. Liu, R. Metzler, J. Phys. A 53, 474001 (2020)

    Article  MathSciNet  ADS  Google Scholar 

  74. A.G. Cherstvy, R. Metzler, J. Stat. Mech. Theory Exp. 2015, P05010 (2015)

    Article  Google Scholar 

  75. A.G. Cherstvy, R. Metzler, Phys. Chem. Chem. Phys. 15, 20220 (2013)

    Article  Google Scholar 

  76. A.V. Chechkin, F. Seno, R. Metzler, I.M. Sokolov, Phys. Rev. X 7, 021002 (2017)

    Google Scholar 

  77. V. Sposini, A.V. Chechkin, F. Seno, G. Pagnini, R. Metzler, New J. Phys. 20, 043044 (2018)

    Article  ADS  Google Scholar 

  78. N. Leibovich, E. Barkai, Phys. Rev. E 99, 042138 (2019)

    Article  ADS  Google Scholar 

  79. A.G. Cherstvy, R. Metzler, Phys. Rev. E 90, 012134 (2014)

    Article  ADS  Google Scholar 

  80. R. Salgado-García, Phys. A 453, 55 (2016)

    Article  MathSciNet  Google Scholar 

  81. B. Wang, S.M. Anthony, S.C. Bae, S. Granick, Proc. Natl. Acad. Sci. U.S.A. 106, 15160 (2009)

    Article  ADS  Google Scholar 

  82. T.J. Lampo, S. Stylianidou, M.P. Backlund, P.A. Wiggins, A.J. Spakowitz, Biophys. J. 112, 532 (2017)

    Article  ADS  Google Scholar 

  83. A.G. Cherstvy, S. Thapa, C.E. Wagner, R. Metzler, Soft. Matter 15, 2526 (2019)

    Article  ADS  Google Scholar 

  84. B. Wang, J. Kuo, S.C. Bae, S. Granick, Nat. Mater. 11, 481 (2012)

    Article  ADS  Google Scholar 

  85. S. Hapca, J.W. Crawford, I.M. Young, J.R. Soc, Interface 6, 111 (2009)

    Google Scholar 

  86. P. Chaudhuri, L. Berthier, W. Kob, Phys. Rev. Lett. 99, 060604 (2007)

    Article  ADS  Google Scholar 

  87. S. Roldián-Vargas, L. Rovigatti, F. Sciortino, Soft Matter 13, 514 (2017)

    Article  ADS  Google Scholar 

  88. T. Toyota, D.A. Head, C.F. Schmidt, D. Mizuno, Soft. Matter 7, 3234 (2011)

    Article  ADS  Google Scholar 

  89. N. Samanta, R. Chakrabarti, Soft. Matter 12, 8554 (2016)

    Article  ADS  Google Scholar 

  90. B.B. Mandelbrot, J.W. Van Ness, Siam Rev. 10, 422 (1968)

    Article  MathSciNet  ADS  Google Scholar 

  91. R. Metzler, J.H. Jeon, A.G. Cherstvy, E. Barkai, Phys. Chem. Chem. Phys. 16, 24128 (2014)

    Article  Google Scholar 

  92. J.H. Jeon, R. Metzler, Phys. Rev. E 85, 021147 (2012)

    Article  ADS  Google Scholar 

  93. J.H. Jeon, R. Metzler, Phys. Rev. E 81, 021103 (2010)

    Article  MathSciNet  ADS  Google Scholar 

  94. C. Beck, Phys. Rev. Lett. 87, 180601 (2001)

    Article  MathSciNet  ADS  Google Scholar 

  95. C. Beck, E.G.D. Cohen, Phys. A 322, 267 (2003)

    Article  MathSciNet  Google Scholar 

  96. M.V. Chubynsky, G.W. Slater, Phys. Rev. Lett. 113, 098302 (2014)

    Article  ADS  Google Scholar 

  97. R.L. Blumberg Selinger, S. Havlin, F. Leyvraz, M. Schwartz, H.E. Stanley, Phys. Rev. A 40, 6755 (1989)

    Article  ADS  Google Scholar 

  98. H. Kesten, Phys. A 138, 299 (1986)

    Article  MathSciNet  Google Scholar 

  99. I. Goychuk, V.O. Kharchenko, R. Metzler, Phys. Rev. E 96, 052134 (2017)

    Article  ADS  Google Scholar 

  100. J.P. Kruse, W. Gu, Cell 137, 609 (2009)

    Article  Google Scholar 

  101. C.J. Brown, S. Lain, C.S. Verma, A.R. Fersht, D.P. Lane, Nat. Rev. Cancer 9, 862 (2009)

    Article  Google Scholar 

  102. R. Beckerman, C. Prives, Cold Spring Harb. Perspect. Biol. 2, a000935 (2010)

    Article  Google Scholar 

  103. K.T. Bieging, S.S. Mello, L.D. Attardi, Nat. Rev. Cancer 14, 359 (2014)

    Article  Google Scholar 

  104. A.C. Joerger, A.R. Fersht, Annu. Rev. Biochem. 77, 557 (2008)

    Article  Google Scholar 

  105. M. Kitayner, H. Rozenberg, R. Rohs, O. Suad, D. Rabinovich, B. Honig, Z. Shakked, Nat. Struct. Mol. Biol. 17, 423 (2010)

    Article  Google Scholar 

  106. R.L. Weinberg, S.M.V. Freund, D.B. Veprintsev, M. Bycroft, A.R. Fersht, J. Mol. Biol. 342, 801 (2004)

    Article  Google Scholar 

  107. K. Kamagata, A. Murata, Y. Itoh, S. Takahashi, J. Photochem. Photobiol. C 30, 36 (2017)

    Article  Google Scholar 

  108. A. Tafvizi, L.A. Mirny, A.M. van Oijen, ChemPhysChem 12, 1481 (2011)

    Article  Google Scholar 

  109. M. Bustin, R. Reeves, Prog. Nucleic Acid Res. Mol. Biol. 54, 35 (1996)

    Article  Google Scholar 

  110. M. Bustin, Mol. Cell. Biol. 19, 5237 (1999)

    Article  Google Scholar 

  111. C. Tan, T. Terakawa, S. Takada, J. Am. Chem. Soc. 138, 8512 (2016)

    Article  Google Scholar 

  112. F. Hanaoka, K. Sugasawa, D.N.A. Replication, Recombination, and Repair: Molecular Mechanisms and Pathology (Springer, New York, 2016)

    Book  Google Scholar 

  113. P. Hammar, P. Leroy, A. Mahmutovic, E.G. Marklund, O.G. Berg, J. Elf, Science 336, 1595 (2012)

    Article  ADS  Google Scholar 

  114. J.H. Min, N.P. Pavletich, Nature 449, 570 (2007)

    Article  ADS  Google Scholar 

  115. X. Chen, Y. Velmurugu, G. Zheng, B. Park, Y. Shim, Y. Kim, L. Liu, B. Van Houten, C. He, A. Ansari, J.H. Min, Nat. Commun. 6, 5849 (2015)

    Article  ADS  Google Scholar 

  116. K. Sugasawa, Mechanism and regulation of DNA damage recognition in mammalian nucleotide excision repair. In Enzymes (Academic Press, Cambridge, MA, 2019), ed. by L. Zhao, L.S. Kaguni, pp. 99–138

  117. A. Sfeir, T. de Lange, Science 336, 593 (2012)

    Article  ADS  Google Scholar 

  118. K.K. Bisht, Z. Daniloski, S. Smith, J. Cell Sci. 126, 3493 (2013)

    Google Scholar 

  119. A. Banerjee, W.L. Santos, G.L. Verdine, Science 311, 1153 (2006)

    Article  ADS  Google Scholar 

  120. Y. Qi, M.C. Spong, K. Nam, M. Karplus, G.L. Verdine, J. Biol. Chem. 285, 1468 (2010)

    Article  Google Scholar 

  121. C. Schick, C.T. Martin, Biochemistry 34, 666 (1995)

    Article  Google Scholar 

  122. T. Li, H.H. Ho, M. Maslak, C. Schick, C.T. Martin, Biochemistry 35, 3722 (1996)

    Article  Google Scholar 

  123. G.M.T. Cheetham, D. Jeruzalmi, T.A. Steitz, Nature 399, 80 (1999)

    Article  ADS  Google Scholar 

  124. D. Imburgio, M. Rong, K. Ma, W.T. McAllister, Biochemistry 39, 10419 (2000)

    Article  Google Scholar 

  125. T. Miyaguchi, T. Akimoto, E. Yamamoto, Phys. Rev. E 94, 012109 (2016)

    Article  MathSciNet  ADS  Google Scholar 

  126. T. Miyaguchi, T. Uneyama, T. Akimoto, Phys. Rev. E 100, 012116 (2019)

    Article  ADS  Google Scholar 

  127. B. Bouvier, K. Zakrzewska, R. Lavery, Angew. Chem. 50, 6516 (2011)

    Article  Google Scholar 

  128. M.J. Saxton, Biophys. J. 92, 1178 (2007)

    Article  ADS  Google Scholar 

  129. A. Godec, A.V. Chechkin, E. Barkai, H. Kantz, R. Metzler, J. Phys. A 47, 492002 (2014)

    Article  MathSciNet  Google Scholar 

  130. V.O. Kharchenko, I. Goychuk, Phys. Rev. E 87, 052119 (2013)

    Article  ADS  Google Scholar 

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Acknowledgements

This work was supported by the National Research Foundation (NRF) of Korea through No. 2018R1A6A3A11043366 (O.L.), No. 2020R1I1A1A01071790 (X.D.), and No. 2017K1A1A2013241 (J-H.J.).

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  1. Department of Physics, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea

    Seongyu Park, O-chul Lee, Xavier Durang & Jae-Hyung Jeon

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Park, S., Lee, Oc., Durang, X. et al. A mini-review of the diffusion dynamics of DNA-binding proteins: experiments and models. J. Korean Phys. Soc. 78, 408–426 (2021). https://doi.org/10.1007/s40042-021-00060-y

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