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Antibiotic Resistance Microbes’ (ARM) Mechanisms and Management: A Phytomedicinal Approach

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Proceedings of the National Academy of Sciences, India Section B: Biological Sciences Aims and scope Submit manuscript

Abstract

Chemical substances known as antibiotics work to inhibit the division of bacteria (bacteriostasis) or to actually kill the bacteria (bactericidal). Microbes that are resistant to antibiotics have been called “nightmare bacteria” and have been said to “represent a catastrophic threat” to human health on a worldwide scale. The genetic basis of antibiotic resistance in superbugs has evolved through the acquisition of a resistant determinant via horizontal gene transfer, which makes the exploration of phytomedicinal remedy a no-brainer eliciting good success in superbug-causing maladies. In this review, we juxtaposed the phytomedicinal approach for the management of Antibiotics Resistance microbes (ARM). Nigella sativa, black pepper (Piper nigrum L.), thyme essential oils and many other plants’ phytochemical, and medicinal compounds were dissected in this review. These plants have proved to possess medicinal and pharmacological properties in ameliorating the burden of antibiotic resistance microbes responsible for nosocomial infection mortality. Our literature review considered these ethno-botanical plants and their essential oils as members of the kingdom of medicinal agents, which includes a variety of bioactive compounds with potential nutraceutical and pharmaceutical applications as well as synergistic plants’ phyto-compounds-broad spectrum drugs dynamics. On the basis of knowledge gaps, suggestions have been made for systematic evaluation of plant derivatives for the development of plant-based medicines and nutraceuticals, as well as for the evaluation of their clinical efficacy and safety on resistance to antibiotics.

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Abbreviations

ARM:

Antibiotics resistance microbes

GRAM:

Global report on antimicrobial

MIC:

Minimum inhibitory concentration

MBC:

Minimum bactericidal concentration

ATP:

Adenosine triphosphate

MDR:

Multidrug-resistant

ARB:

Antibiotic resistant bacteria

MFC:

Minimum fungicidal concentration

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Acknowledgements

Authors appreciate the scholars whose literature review of the subject matter was cited in the manuscript text.

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Authors and Affiliations

  1. Department of Biochemistry, School of Life Sciences, Federal University of Technology, PMB 704, Akure, Nigeria

    Blessing Temitope Lawani, Muyideen Enitan Sadibo, Elizabeth Foluke Awodire & Olayemi Philemon Aro

  2. Department of Microbiology, School of Life Sciences, Federal University of Technology, PMB 704, Akure, Nigeria

    Michael Tosin Bayode

  3. Department of Microbiology, Ondo State University of Science and Technology, Okitipupa, Nigeria

    Abosede Ayodeji Akindele

Authors
  1. Blessing Temitope Lawani
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  6. Abosede Ayodeji Akindele
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Contributions

BTL and MTB devised the review concept. MTB drafted the outline and structure of the review. MES performed the literature survey on antimicrobial peculiarities of essential oil, EFA performed literature survey on the mode of essential oil activity and OPA wrote the background of the review draft. AAA and MTB formatted and previewed the first draft. All authors read and approved the final manuscript draft.

Corresponding author

Correspondence to Michael Tosin Bayode.

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Significance Statement: The efficacy of medicinal plants’ essential oils warrants exploration in combating antibiotics resistant microbes for public health safety.

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Lawani, B.T., Bayode, M.T., Sadibo, M.E. et al. Antibiotic Resistance Microbes’ (ARM) Mechanisms and Management: A Phytomedicinal Approach. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. (2023). https://doi.org/10.1007/s40011-023-01525-9

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