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Biocompatible biodegradable polymeric nanocarriers in dry powder inhalers (DPIs) for pulmonary inhalation delivery

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Abstract

Background

Pulmonary drug delivery is an efficient way to deliver drugs directly to the site of action i.e., lungs or to the blood circulation with minimum systemic effects. Recent emergence of coronavirus disease-2019 (COVID-19) and expeditious development of nanoparticle-based vaccines have recently reignited considerable interest in designing inhalable nanoparticle-based drug delivery systems as next-generation respiratory therapeutics.

Area covered

In this review, dry powder inhaler (DPI) formulations based on polymeric nanoparticles have been reviewed. It comprehensively describes various biodegradable and biocompatible synthetic (e.g. polylactic-glycolic acid, polyethylene glycol, polyethylenimine, and polycaprolactone) and natural (e.g. alginate, chitosan, dextran, hyaluronic acid, and gelatin) polymers used in formulating nanoparticle-based dry powder inhalers. This review covers the most recent drugs encapsulated in synthetic-based and natural-based biocompatible nanocarriers used in DPIs, providing latest approaches for treating various respiratory and pulmonary disorders.

Expert Opinion

DPIs comprised of biocompatible biodegradable polymeric nanocarriers exhibited favorable particle properties and aerodynamic properties. In addition, these polymeric nanocarriers are chemically versatile in being either synthetic or natural. This chemical versatility enables versatility in the various types of drugs that can be incorporated into DPIs provided that the needed particle properties and aerodynamic properties are maintained.

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Authors and Affiliations

  1. Mathematics and Engineering, Department of Physics, Universidad de Sonora, Campus Navojoa, 85880, Sonora, Mexico

    David Encinas-Basurto

  2. Center for Translational Science, International University, 11350 SW Village Pkwy, Port St, 34987, Lucie, FL, USA

    Basanth Babu Eedara & Heidi M. Mansour

  3. Robert Stempel College of Public Health and Social Work, Department of Environmental Health Sciences, Florida International University, Port St. Lucie, FL, USA

    Basanth Babu Eedara & Heidi M. Mansour

  4. Herbert Wertheim College of Medicine, Department of Cellular and Molecular Medicine, Florida International University, Port St. Lucie, FL, USA

    Heidi M. Mansour

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  1. David Encinas-Basurto
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Correspondence to Heidi M. Mansour.

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Encinas-Basurto, D., Eedara, B.B. & Mansour, H.M. Biocompatible biodegradable polymeric nanocarriers in dry powder inhalers (DPIs) for pulmonary inhalation delivery. J. Pharm. Investig. 54, 145–160 (2024). https://doi.org/10.1007/s40005-024-00671-0

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