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Sodium alginate–arabinoxylan composite microbeads: preparation and characterization

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Abstract

The objective of present study was to prepare composite microbeads of psyllium arabinoxylan and sodium alginate by ionotropic gelation method using calcium chloride as a cross linker and was further evaluated for release study. The effect of concentration of sodium alginate/arabinoxylan and concentration of calcium chloride on the entrapment efficiency and on % release were studied employing 2-factor, 3-level central composite experimental design. The results of the study revealed that interaction effect of the concentration of sodium alginate/arabinoxylan and calcium chloride influenced the entrapment efficiency and release of diclofenac sodium significantly. The optimal calculated parameters were found to be concentration of sodium alginate/arabinoxylan-5 and concentration of calcium chloride-0.75 M, that provided microbeads with entrapment efficiency-64.4 % and release of 28.5 % of the drug over 8 h period of study. Further, arabinoxylan–sodium alginate mucoadhesive microbeads were found to sustain the release of diclofenac sodium over a period of 8 h following zero order kinetics with the mechanism of release being diffusion.

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References

  • Ahuja M, Bhatia M (2013) Thiol modification of psyllium husk mucilage and evaluation of its mucoadhesive applications. Sci World J, 1–7

  • Ahuja M, Bhatia M (2015) Psyllium arabinoxylan: carboxymethylation, characterization and evaluation for nanoparticulate drug delivery. Int J Biol Macromol 72:495–501

    Article  PubMed  Google Scholar 

  • Bindu D, Bharat P, Kumar AC (2012) Psyllium: a potential carrier to control the drug delivery. Int Res J Pharm 3(7):39–44

    Google Scholar 

  • Fernandez-Banares F (2006) Nutritional care of the patient with constipation. Best Pract Res Clin Gastroenterol 20:575–587

    Article  CAS  PubMed  Google Scholar 

  • Fischer MH, Yu N, Gray GR, Ralph J, Anderson L, Marlett JA (2004) The gel-forming polysaccharide of psyllium husk (Plantago ovata Forsk). Carbohydr Res 339:2009–2017

    Article  CAS  PubMed  Google Scholar 

  • George M, Abraham TE (2006) Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan- a review. J Control Release 114:1–14

    Article  CAS  PubMed  Google Scholar 

  • Higuchi T (1961) Rate of release of medicaments from ointment bases containing drugs in suspension. J Pharm Sci 50:874–875

    Article  CAS  PubMed  Google Scholar 

  • Mathew ST, Devi SG, Prasanth VV, Vinod B (2009) Formulation and in vitro-in vivo evaluation of ketoprofen-loaded albumin microspheres for intramuscular administration. J Microencapsul 26:456–469

    Article  CAS  PubMed  Google Scholar 

  • Mishra A, Srinivasan R, Gupta R (2003) Plantago psyllium-g-polyacrylonitrile: synthesis and characterization. Colloid Polym Sci 281:187–189

    Article  CAS  Google Scholar 

  • Mishra A, Yadav M, Agarwal S, Rajani S (2004) Polyacrylonitrile grafted Plantago psyllium mucilage for the removal of suspended and dissolved solid from tannery effluent. Colloid Polym Sci 282:300–303

    Article  CAS  Google Scholar 

  • Mishra S, Sinha S, Dey KP, Sen G (2014) Synthesis, characterization and applications of polymethylmethacrylate grafted psyllium as flocculant. Carbohydr Polym 99:462–468

    Article  CAS  PubMed  Google Scholar 

  • Nayak AK, Pal DK, Santra K (2013) Plantago ovata F. mucilage-alginate mucoadhesive beads for controlled release of glibenclamide: development, optimization, and in vitro-in vivo evaluation. J Pharm, 1–11

  • Oliver SD (2000) The long-term safety and tolerability of ispaghula husk. J R Soc Health 120:107–111

    Article  CAS  Google Scholar 

  • Pendyala Y, Talasila S (2012) Formulation and evaluation of chitosan loaded mucoadhesive microspheres of ramipril. Int J Pharm Chem Sci 1(3):904–911

    Google Scholar 

  • Sandhu JS, Hudson J, Kennedy JF (1981) The gel nature and structure of the Lotfipour F, Mirzaeei S, Maghsoodi M. Preparation and characterization of alginate and psyllium beads containing Lactobacillus acidophilus. Sci World J, 1–8

  • Shazia S, Iqbal MS, Hussain MA, Koschella A, Heinze T (2008) Structure characterization and carboxymethylation of arabinoxylan isolated from Ispaghula (Plantago ovata) seed husk. Carbohydr Polym 74(2):309–317

    Article  Google Scholar 

  • Shazia S, Iqbal MS, Koschella MA, Heinze T (2009) Ethylation of arabinoxylan from ispaghula (Plantago ovata) seed husk. Carbohydr Polym 77:125–130

    Article  Google Scholar 

  • Shidhaye S, Desai A, Kadam VJ (2007) Possible use of psyllium husk as a release retardant. Indian J Pharm Sci 69(2):206–210

    Article  Google Scholar 

  • Singh B (2007) Psyllium as therapeutic and drug delivery agent. Int J Pharm 334:1–14

    Article  CAS  PubMed  Google Scholar 

  • Singh B, Kumar S (2008) Synthesis and characterization of psyllium-NVP based drug delivery system through radiation crosslinking polymerization. Nucl Instrum Methods Phys Res Sect B 266:3417–3430

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors (M. Ahuja, M. Bhatia, K. Saini) declare that they have no conflict of interest. This article does not contain any studies with human and animal subjects performed by any of the authors. The authors are grateful to IIT, New Delhi, for carrying out the SEM studies.

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Authors and Affiliations

  1. Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125001, India

    Munish Ahuja, Meenakshi Bhatia & Komal Saini

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  1. Munish Ahuja
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  2. Meenakshi Bhatia
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  3. Komal Saini
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Correspondence to Meenakshi Bhatia.

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Ahuja, M., Bhatia, M. & Saini, K. Sodium alginate–arabinoxylan composite microbeads: preparation and characterization. Journal of Pharmaceutical Investigation 46, 645–653 (2016). https://doi.org/10.1007/s40005-016-0244-1

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  • DOI: https://doi.org/10.1007/s40005-016-0244-1

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