Skip to main content

Advertisement

SpringerLink
Log in

Interest of immunodeficiency screening in adult after admission in medical intensive care unit for severe infection, a retrospective and a prospective study: the Intensive Care Unit and Primary and Secondary Immunodeficiency (ICUSPID) study

  • Brief Report
  • Published:
Infection Aims and scope Submit manuscript

Abstract

Background

Primary immunodeficiency (PID) in adults is rare and mostly revealed by infections.

Material and Methods

Adults without predisposing factors who were admitted to an intensive care unit (ICU) for infection were screened for PID.

Results

Six PID cases were diagnosed, mostly revealed by encapsulated bacterial infections.

Conclusion

Investigation of PID after ICU discharge should be considered to improve early detection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Mahlaoui N, Jais JP, Brosselin P, et al. Prevalence of primary immunodeficiencies in France is underestimated. J Allergy Clin Immunol. 2017;140:1731–3.

    Article  PubMed  Google Scholar 

  2. Picard C, Bobby Gaspar H, Al-Herz W, et al. International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee report on inborn errors of immunity. J Clin Immunol. 2017;38:96–128.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Srinivasa BT, Alizadehfar R, Desrosiers M, Shuster J, Pai NP, Tsoukas CM. Adult primary immune deficiency: what are we missing? Am J Med. 2012;125:779–86.

    Article  PubMed  Google Scholar 

  4. EUROPEAN SOCIETY FOR IMMUNODEFICIENCIES. http://esid.org/.

  5. Zhou J, Qian C, Zhao M, et al. Epidemiology and outcome of severe sepsis and septic shock in intensive care units in mainland China. PLoS One. 2014;9:e107181.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Conley ME, Notarangelo LD, Etzioni A. Diagnostic criteria for primary immunodeficiencies. Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies). Clin Immunol. 1999;93:190–7.

    Article  CAS  PubMed  Google Scholar 

  7. Lopez B, Bahuaud M, Fieschi C, et al. Value of the overall pneumococcal polysaccharide response in the diagnosis of primary humoral immunodeficiencies. Front Immunol. 2017;8:1862.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Suavinho E, de Napolis AC, Segundo GR. Primary immunodeficiency investigation in patients during and after hospitalization in a pediatric intensive care unit. Rev Paul Pediatr. 2014;32:32–6.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Gathmann B, Mahlaoui N, Ceredih, et al. Clinical picture and treatment of 2212 patients with common variable immunodeficiency. J Allergy Clin Immunol. 2014;134:116–26.

    Article  PubMed  Google Scholar 

  10. Lopez B, Boucher A, Bahuaud M, et al. Specific polysaccharide antibody deficiency revealed by severe bacterial infections in adulthood: a report on 11 cases. Clin Infect Dis. 2017;65:328–31.

    Article  PubMed  Google Scholar 

  11. Sanges S, Wallet F, Blondiaux N, et al. Diagnosis of primary antibody and complement deficiencies in young adults after a first invasive bacterial infection. Clin Microbiol Infect. 2017;23:576

    Article  PubMed  Google Scholar 

  12. Audemard-Verger A, Descloux E, Ponard D, et al. Infections revealing complement deficiency in adults: a French nationwide study enrolling 41 patients. Medicine (Baltimore). 2016;95:e3548.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors acknowledge the French National Reference Centre for PID, CEREDIH.

Funding

None.

Author information

Author notes

  1. Aurélie Baldolli and Nicolas Martin Silva are equal contributor.

Authors and Affiliations

  1. Department of Infectious Diseases, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France

    Aurélie Baldolli

  2. Department of Internal Medicine, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France

    Nicolas Martin Silva, Gwenola Maigne, Audrey Sultan & Samuel Deshayes

  3. Department of Intensive Care Unit, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France

    Amélie Seguin, Damien Du Cheyron & Aurélie Joret

  4. French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

    Nizar Mahlaoui

  5. Pediatric Immuno-Haematology and Rheumatology Unit, Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

    Nizar Mahlaoui

  6. INSERM UMR1163, Imagine Institute, Sorbonne Paris Cité, University Paris Descartes, Paris, France

    Nizar Mahlaoui

  7. Internal Medicine Department, Saint-Joseph Hospital, Boulevard de Louvain, 13008, Marseille, France

    Boris Bienvenu

  8. Groupe de Recherche sur l’Adaptation Microbienne (GRAM 2.0), Université Caen Normandie, 14000, Caen, France

    Aurélie Baldolli

Authors
  1. Aurélie Baldolli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nicolas Martin Silva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Amélie Seguin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gwenola Maigne
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Audrey Sultan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Samuel Deshayes
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Damien Du Cheyron
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Aurélie Joret
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Nizar Mahlaoui
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Boris Bienvenu
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

AB, NMS, GM, AS, AS, SD, DDC, AJ, NM and BB collected the data and drafted the report. AB, NMS, GM analyzed and interpreted the data. All authors read and approved the final report.

Corresponding author

Correspondence to Aurélie Baldolli.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Baldolli, A., Martin Silva, N., Seguin, A. et al. Interest of immunodeficiency screening in adult after admission in medical intensive care unit for severe infection, a retrospective and a prospective study: the Intensive Care Unit and Primary and Secondary Immunodeficiency (ICUSPID) study. Infection 47, 87–93 (2019). https://doi.org/10.1007/s15010-018-1215-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15010-018-1215-4

Keywords

Search

Navigation