Skip to main content

Advertisement

Log in

Determination of bisphenol-A in plastic bottled water in markets of Zanjan, Iran

  • Original Paper
  • Published:
International Journal of Environmental Science and Technology Aims and scope Submit manuscript

Abstract

Each year, millions of tons of bisphenol-A (BPA) are produced and used in the global economy. In children, BPA exposure causes impaired brain development, attention deficit hyperactivity disorder (ADHD), as well as anxiety and metabolic-related disorders. Pregnant women, infants and young children face the greatest risk from BPA exposure. Under public pressure, BPA has been banned from baby bottles, but BPA is still being heavily used in the industry and numerous consumer products. Using high-performance liquid chromatography coupled with a UV detector (HPLC–UV), we measured BPA (mg L−1) in fifteen local brands of plastic bottled water (n = 24) which are sold in markets of Zanjan, Iran. BPA levels ranged between “non-detectable” to 0.98 mg L−1. Spearman correlation test did not detect significant relationships between BPA and bottle color, its volume, or water pH. BPA increased, though negligibly, with increasing storage time and sunlight exposure. The estimated daily intake (EDI) was 0.075 × 10–3 μg kg-bw−1 day−1. Levels of BPA in bottled waters of the City of Zanjan were negligible. Protection of humans, wildlife and planet earth requires nothing less than a total ban on BPA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

Notes

  1. Not detectable.

Abbreviations

BPA: :

Bisphenol-A

EDI: :

Estimated Daily Intake

mg L 1 : :

Parts-Per-Million

PET: :

Poly Ethylene Terephthalate

PC: :

Polycarbonate

WHO: :

World Health Organization

HPLC: :

High-Performance Liquid Chromatography

LOD: :

Limit of Detection

LOQ: :

Limit of Quantification

EPA: :

U.S. Environmental Protection Agency

EFSA: :

European Food Safety Authority

References

  • Almeida S, Raposo A, Almeida-González M, Carrascosa C (2018) Bisphenol A: food exposure and impact on human health. Compr Rev Food Sci Food Saf 17:1503–1517

    Article  Google Scholar 

  • Andújar N, Gálvez-Ontiveros Y, Zafra-Gómez A, Rodrigo L, Álvarez-Cubero MJ, Aguilera M, Monteagudo C, Rivas A (2019) Bisphenol A analogues in food and their hormonal and obesogenic effects: a review. Nutrients 11:2136

    Article  Google Scholar 

  • Arnich N, Canivenc-Lavier M-C, Kolf-Clauw M, Coffigny H, Cravedi J-P, Grob K, Macherey A-C, Masset D, Maximilien R, Narbonne J-F (2011) Conclusions of the French Food Safety Agency on the toxicity of bisphenol A. Int J Hyg Environ Health 214:271–275

    Article  CAS  Google Scholar 

  • Asimakopoulos AG, Wang L, Thomaidis NS, Kannan K (2014) A multi-class bioanalytical methodology for the determination of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters, benzophenone-type ultraviolet filters, triclosan, and triclocarban in human urine by liquid chromatography–tandem mass spectrometry. J Chromatogr A 1324:141–148

    Article  CAS  Google Scholar 

  • Baralić K, Živančević K, Javorac D, Djordjevic AB, Anđelković M, Jorgovanović D, Miljaković EA, Ćurčić M, Bulat Z, Antonijević B (2020) Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats. Food Chem Toxicol 143:111540

    Article  Google Scholar 

  • Cooper JE, Kendig EL, Belcher SM (2011) Assessment of bisphenol A released from reusable plastic, aluminium and stainless steel water bottles. Chemosphere 85:943–947

    Article  CAS  Google Scholar 

  • Crews D, Putz O, Thomas P, Hayes T, Howdeshell K (2003) Animal models for the study of the effects of mixtures, low doses, and the embryonic environment on the action of endocrine disrupting chemicals. Pure Appl Chem SCOPE/IUPAC Proj Impl Endocrine Active Subst Humans Wildlife 75:2305–2320

    CAS  Google Scholar 

  • Deng P, Xu Z, Kuang Y (2014) Electrochemical determination of bisphenol A in plastic bottled drinking water and canned beverages using a molecularly imprinted chitosan–graphene composite film modified electrode. Food Chem 157:490–497

    Article  CAS  Google Scholar 

  • EFSA C (2015) Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on Flavouring Group Evaluation 208 Revision 1 (FGE. 208Rev1): consideration of genotoxicity data on representatives for 10 alicyclic aldehydes with the a, b-unsaturation in ring/side-chain and precursors from chemical subgroup 2.2 of FGE. 19. EFSA Journal 2015; 13 (7): 4173, 28 pp.

  • Elobeid MA, Almarhoon ZM, Virk P, Hassan ZK, Omer SA, Elamin M, Daghestani MH, Alolayan EM (2012) Bisphenol a detection in various brands of drinking bottled water in Riyadh, Saudi Arabia using gas chromatography/mass spectrometer. Trop J Pharm Res 11:455–459

    CAS  Google Scholar 

  • Fan Y-Y, Zheng J-L, Ren J-H, Luo J, Cui X-Y, Ma LQ (2014) Effects of storage temperature and duration on release of antimony and bisphenol A from polyethylene terephthalate drinking water bottles of China. Environ Pollut 192:113–120

    Article  CAS  Google Scholar 

  • Flint S, Markle T, Thompson S, Wallace E (2012) Bisphenol A exposure, effects, and policy: a wildlife perspective. J Environ Manage 104:19–34

    Article  CAS  Google Scholar 

  • Geens T, Aerts D, Berthot C, Bourguignon J-P, Goeyens L, Lecomte P, Maghuin-Rogister G, Pironnet A-M, Pussemier L, Scippo M-L (2012) A review of dietary and non-dietary exposure to bisphenol-A. Food Chem Toxicol 50:3725–3740

    Article  CAS  Google Scholar 

  • Gerona R, vom Saal FS, Hunt PA (2020) BPA: have flawed analytical techniques compromised risk assessments? Lancet Diabetes Endocrinol 8:11–13

    Article  Google Scholar 

  • Goeury K, Duy SV, Munoz G, Prévost M, Sauvé S (2019) Analysis of environmental protection agency priority endocrine disruptor hormones and bisphenol A in tap, surface and wastewater by online concentration liquid chromatography tandem mass spectrometry. J Chromatogr A 1591:87–98

    Article  CAS  Google Scholar 

  • Gore A, Chappell V, Fenton S, Flaws J, Nadal A, Prins G, Toppari J, Zoeller R (2015) Executive summary to EDC-2: the Endocrine Society’s second scientific statement on endocrine-disrupting chemicals. Endocr Rev 36:593–602

    Article  CAS  Google Scholar 

  • Gorji S, Bahram M, Biparva P (2019) Optimized stir bar sorptive extraction based on self-magnetic nanocomposite monolithic kit for determining Bisphenol A in bottled mineral water and bottled milk samples. Analyt Bioanalyt Chem Res 6:137–156

    CAS  Google Scholar 

  • Hajian R, Tayebi Z, Shams N (2017) Fabrication of an electrochemical sensor for determination of doxorubicin in human plasma and its interaction with DNA. J Pharmaceut Anal 7:27–33

    Google Scholar 

  • Hu X, Wu X, Yang F, Wang Q, He C, Liu S (2016) Novel surface dummy molecularly imprinted silica as sorbent for solid-phase extraction of bisphenol A from water samples. Talanta 148:29–36

    Article  CAS  Google Scholar 

  • Huang Y, Wong C, Zheng J, Bouwman H, Barra R, Wahlström B, Neretin L, Wong MH (2012) Bisphenol A (BPA) in China: a review of sources, environmental levels, and potential human health impacts. Environ Int 42:91–99

    Article  CAS  Google Scholar 

  • Kazemi A, Younesi H, Bahramifar N (2014) Migration of bisphenol A and nonylphenol from mineral water bottles and disposable plastic containers into water at different temperatures. Iran J Health Environ 6:515–522

    Google Scholar 

  • Le HH, Carlson EM, Chua JP, Belcher SM (2008) Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons. Toxicol Lett 176:149–156

    Article  CAS  Google Scholar 

  • Li Y, Lu P, Cheng J, Zhu X, Guo W, Liu L, Wang Q, He C, Liu S (2018) Novel microporous β-cyclodextrin polymer as sorbent for solid-phase extraction of bisphenols in water samples and orange juice. Talanta 187:207–215

    Article  CAS  Google Scholar 

  • Neufeld K, Ezell K, Grow WA (2015) Plastic additives decrease agrin-induced acetylcholine receptor clusters and myotube formation in C2C12 skeletal muscle cell culture. Cell Bio 4:12

    Google Scholar 

  • Omer L, Ahmed H, Elbashir A (2016) Determination of bisphenol A in exposed bottled water samples to direct sun light using multi walled carbon nanotubes as solid phase extraction sorbent. J Environ Chem Ecotoxicol 8:51–57

    Article  CAS  Google Scholar 

  • Rykowska I, Wasiak W (2006) Properties, threats, and methods of analysis of bisphenol A and its derivatives. Acta Chromatogr 16:7

    CAS  Google Scholar 

  • Santhi V, Sakai N, Ahmad E, Mustafa A (2012) Occurrence of bisphenol A in surface water, drinking water and plasma from Malaysia with exposure assessment from consumption of drinking water. Sci Total Environ 427:332–338

    Article  Google Scholar 

  • Sinuco D, Castillo E, Rodríguez R, Durán C (2019) Migracion especifica de bisfenol a (BPA) en biberones fabricados en Colombia/Specific migration of bisphenol to (BPA) in bottles made in Colombia. Informador Tecnico 83:30–36

    Google Scholar 

  • Tran NH, Hu J, Ong SL (2013) Simultaneous determination of PPCPs, EDCs, and artificial sweeteners in environmental water samples using a single-step SPE coupled with HPLC–MS/MS and isotope dilution. Talanta 113:82–92

    Article  CAS  Google Scholar 

  • Vandenberg LN, Hunt PA, Gore AC (2019) Endocrine disruptors and the future of toxicology testing—lessons from CLARITY–BPA. Nat Rev Endocrinol 15:366–374

    Article  CAS  Google Scholar 

  • vom Saal FS, Vandenberg LN (2021) Update on the health effects of bisphenol A: overwhelming evidence of harm. Endocrinology 162:bqaa171

    Article  Google Scholar 

  • Zhang L, Fang P, Yang L, Zhang J, Wang X (2013) Rapid method for the separation and recovery of endocrine-disrupting compound bisphenol AP from wastewater. Langmuir 29:3968–3975

    Article  CAS  Google Scholar 

  • Zhang H, Zhang Y, Li J, Yang M (2019) Occurrence and exposure assessment of bisphenol analogues in source water and drinking water in China. Sci Total Environ 655:607–613

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors thank members of the Environmental Group at University of Zanjan for their support and contributions to this study.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J. Aazami.

Ethics declarations

Conflict of interest

The authors declared that they have no conflicts of interest.

Additional information

Editorial responsibility: Maryam Shabani.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Parto, M., Aazami, J., Shamsi, Z. et al. Determination of bisphenol-A in plastic bottled water in markets of Zanjan, Iran. Int. J. Environ. Sci. Technol. 19, 3337–3344 (2022). https://doi.org/10.1007/s13762-021-03488-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13762-021-03488-8

Keywords

Navigation