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Cerebral microbleeds is associated with dementia in Parkinson’s disease

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A Correction to this article was published on 28 June 2022

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Abstract

Introduction

Emerging evidence suggests that cerebral small vessel disease (CSVD) may worsen cognitive functions in Parkinson’s disease (PD). However, the effect of microbleeds on cognitive function in patients with PD remains unknown. This study explored the association between the presence, number and location of microbleeds with dementia in PD patients.

Methods

This cross-sectional study included 431 patients with PD from Beijing Tiantan Hospital from May 2016 to August 2019. Cognition assessments (MMSE, MoCA) were performed for these patients. MRI imaging sequences were obtained and reviewed independently by two well-trained readers who were blind to all clinical data. Spearman’s correlation analysis and logistic regression model analysis were further used for the assessments.

Results

An association between cerebral microbleeds with cognitive ability and dementia in PD patients was revealed. A significance was observed between the total number of microbleeds and two widely used scores of cognitive assessments (Spearman R = − 0.120 to MMSE with a p = 0.016, and − 0.117 to MoCA with a p = 0.020). In detail, infratentorial microbleeds were associated with the level of cognition in PD patients (Spearman R = − 0.099 to MMSE with a p = 0.049, and − 0.116 to MoCA with a p = 0.021). Furthermore, logistic regression analysis results also confirmed such correlations between the number of microbleeds and cognitive ability after adjusting for age, cholesterol level, Hamilton Anxiety Scale, Hamilton Depression Scale, and white matter hyperintensity Fazekas score (OR 3.28, p = 0.035, 95% CI 1.090–9.892).

Conclusions

The occurrence of microbleeds, especially in the infratentorial locations, may worsen the cognitive function of PD patients and result in dementia. Management of cerebral vascular disease could be beneficial to patients with PD.

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Availability of data and material

The datasets supporting the results of this article are included within the article.

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Funding

This research was supported by National Key R&D Program of China (No. 2017YFC1307900, 2017YFC1307905); The National Natural Science Foundation of China (No.81825007); Beijing Outstanding Young Scientist Program (No. BJJWZYJH01201910025030); Youth Beijing Scholar Program (No.010); Beijing Talent Project—Class A: Innovation and Development (No. 2018A12); “National Ten-Thousand Talent Plan”—Leadership of Scientific and Technological Innovation; Beijing Hospital Project (BJ-2021-197).

Author information

Author notes

  1. Huijuan Wan and Huimin Chen share the equal work.

Authors and Affiliations

  1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China

    Huijuan Wan, Meimei Zhang, Tao Feng & Yilong Wang

  2. China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, China

    Huijuan Wan, Meimei Zhang, Tao Feng & Yilong Wang

  3. Advanced Innovation Center for Human Brain Projection, Capital Medical University, Beijing, China

    Huijuan Wan, Meimei Zhang, Tao Feng & Yilong Wang

  4. Department of Neurology, First Affiliated Hospital, Xiamen University, Xiamen, China

    Huijuan Wan

  5. Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China

    Huimin Chen

  6. Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China

    Yilong Wang

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  1. Huijuan Wan
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  4. Tao Feng
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Contributions

YW and TF have given substantial contributions to the conception or the design of the manuscript, HW, HC, and MZ to acquisition, analysis and interpretation of the data. All the authors have participated in drafting the manuscript, YW revised it critically. All the authors read and approved the final version of the manuscript.

Corresponding authors

Correspondence to Tao Feng or Yilong Wang.

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Conflict of interest

None of the authors has potential conflicts of interest to be disclosed.

Ethical approval

This study was approved by the Ethics Committee of the Beijing Tiantan Hospital (approval number: Z171100000117013), and was performed in accordance with the Declaration of Helsinki.

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Informed consent was obtained from all the participants.

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Wan, H., Chen, H., Zhang, M. et al. Cerebral microbleeds is associated with dementia in Parkinson’s disease. Acta Neurol Belg 123, 407–413 (2023). https://doi.org/10.1007/s13760-022-01918-z

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  • DOI: https://doi.org/10.1007/s13760-022-01918-z

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