Abstract
We wanted to explore possible differences in disease presentation, frequency, and age of onset of dementia with Lewy bodies (DLB) between first-generation immigrants (FGI) and patients born in Belgium (PBIB). We conducted a retrospective study on all patients of our Memory Clinic between June 1, 2010 and January 31, 2020. A synucleinopathy was diagnosed in 150 of 2702 patients (5.5%): 91 received a diagnosis of DLB (3.4%). FGI were two times more likely to receive a diagnosis of DLB, due to a higher prevalence in North-Africans and Latin-Americans. Visual hallucinations were less frequent in North-Africans than in other immigrants. FGI were younger than PBIB and reported more often parasomnia. Our data suggest a higher risk for DLB in certain immigrant groups. Especially for North-African patients, a genetic factor can be suspected, namely mutations in Leucine-rich repeat kinase 2 (LRRK2). Memory clinics with a high rate of FGI may provide interesting data and insights into the prevalence of DLB, genetic and environmental differences.
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References
Jellinger KA, Korczyn AD (2018) Are dementia with Lewy bodies and Parkinson's disease dementia the same disease? BMC Med 16:34
Galvin JE, Balasubramaniam M. (2013) Lewy body dementia: the under-recognized but common FOE. In: Cerebrum: the Dana forum on brain science, p 13
Segers K, Benoit F, Colson C, Kovac V, Nury D, Vanderaspoilden V (2013) Pioneers in migration, pioneering in dementia: first generation immigrants in a cosmopolitan memory clinic. Acta Neurol Belg 113:435–440
McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG et al (2017) Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology 89:88–100
Yamada M, Komatsu J, Nakamura K, Sakai K, Samuraki-Yokohama M, Nakajima K, Yoshita M (2020) Diagnostic criteria for dementia with Lewy bodies: updates and future directions. J Mov Disord 13:1–10
Dubois B, Feldmann HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G et al (2007) Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 6:734–746
Custodio N, Wheelock A, Thumala D, Slachevsky A (2017) Dementia in Latin America: epidemiological evidence and implications for public policy. Front Aging Neurosci 13:221
Benamer HT, de Silva R, Siddiqui KA, Grosset DG (2008) Parkinson's disease in Arabs: a systematic review. Mov Disord 23:1205–1210
Ben-Joseph A, Marshal CR, Lees AJ, Noyce AJ (2020) Ethnic variation in the manifestation of Parkinson’s disease: a narrative review. J Park Dis 10:31–45
Suemoto CK, Ferretti-Rebustini RE, Rodriguez RD, Leite RE, Soterio L, Brucki SM, Spera RR, Cippiciani TM, Farfel JM, Filho AC et al (2017) Neuropathological diagnoses and clinical correlates in older adults in Brazil. PLoS Med 14:e1002267
Ogunniyi A, Daif AK, Al-Rajeh S, AbdulJabbar M, Al-Tahan AR, Al-Bunyan M, Shamina AR (1998) Dementia in Saudi Arabia: experience from a university hospital. Acta Neurol Scand 98:116–120
Benamer HT, de Silva R (2010) LRRK2 G2019S in the North African population: a review. Eur Neurol 63:321–325
Zhu X, Babar A, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Perry G, Chen SG (2006) LRRK2 in Parkinson's disease and dementia with Lewy bodies. Mol Neurodegener 1:17
Ben Romdhan S, Farhat N, Nasri A, Lesage S, Hdiji O, Ben Djebara M, Landoulsi Z, Stevanin G, Brice A, Damak M et al (2018) LRRK2 G2019S Parkinson's disease with more benign phenotype than idiopathic. Acta Neurol Scand 138:425–431
Brucki SM (2010) Illiteracy and dementia. Dementia Neuropsy 4:153–157
Ardila A, Bertolucci PH, Braga LW (2010) Illiteracy: the neuropsychology of cognition without reading. Arch Clin Neuropsy 25:689–712
Pont-Sunyer C, Iranzo A, Gaig C, Fernández-Arcos A, Vilas D, Valldeoriola F, Compta Y, Fernández-Santiago R, Fernández M, Bayés A et al (2015) Sleep disorders in Parkinsonian and nonparkinsonian LRRK2 mutation carriers. PLoS ONE 15:10
Saunders-Pullman R, Alcalay RN, Mirelman A, Wang C, San Luciano M, Ortega RA, Glickman A, Raymond D, Mejia-Santana H, Doan N et al (2015) REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers. Mov Disord 30:1834–1839
Boot BP, Orr CF, Ahlskog JE, Ferman TJ, Roberts R, Pankratz VS, Dickson DW, Parisi J, Aakre JA, Geda YE et al (2013) Risk factors for dementia with Lewy bodies: a case-control study. Neurology 81:833–840
NCD Risk Factor Collaboration (NCD-RisC) (2016) Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet 387:1513–1530
Frigerio R, Fujishiro H, Maraganore DM, Klos KJ, DelleDonne A, Heckman MG, Crook JE, Josephs KA, Parisi JE, Boeve BF, Dickson DW, Ahlskog JE et al (2009) Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease. Arch Neurol 66:1114–1119
Boulos C, Yaghi N, El Hayeck R (2019) Nutritional risk factors, microbiota and Parkinson’s disease: what is the current evidence? Nutrients 11:1896
Yan R, Zhang J, Park HJ, Park ES, Oh S, Zheng H, Junn E, Voronkov M, Stock JB, Mouradian MM (2018) Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB. PNAS USA 115:E12053–E12062
Mukadam N, Cooper C, Basi B, Livingston G (2011) Why do ethnic elders present later to UK dementia services? A qualitative study”. Int Psychogeriatr 23:1070–1077
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Segers, K., Benoit, F., Meyts, JM. et al. Dementia with Lewy bodies in first-generation immigrants in a European memory clinic. Acta Neurol Belg 121, 219–223 (2021). https://doi.org/10.1007/s13760-020-01492-2
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DOI: https://doi.org/10.1007/s13760-020-01492-2