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Sleep quality is associated with the severity of clinical symptoms in Parkinson’s disease

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Abstract

Sleep disorders are very common in Parkinson’s disease (PD), being associated with several other conditions, mainly psychiatric disorders. The present study was designed to assess sleep quality in Brazilian patients with PD and to evaluate whether sleep changes are associated with clinical variables, especially neuropsychiatric symptoms in PD. Patients diagnosed with PD were subjected to a comprehensive clinical evaluation that included the assessment of motor, cognitive and psychiatric symptoms. Our study showed that sleep complaints are frequent in PD and worse sleep quality is associated with depressive and anxious symptoms, poorer cognitive performance and greater severity of PD symptoms. In the multivariate analysis, older age, greater severity of anxiety and PD remained as significant predictors of worse sleep quality. In conclusion, sleep complaints, depressive and anxiety symptoms are frequent in PD patients. Older age, disease severity and anxiety symptoms are significant predictors of poorer sleep quality in PD patients.

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Acknowledgements

Authors would like to acknowledge the participation of volunteers in this study and are indebted to their caregivers for their magnificent support.

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Authors and Affiliations

  1. Laboratório Interdisciplinar de Investigação Médica (LIIM), Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena 190, Sala 281, Belo Horizonte, MG, 30130-100, Brazil

    Bruno T. Junho, Arthur Kummer, Antonio L. Teixeira & Natalia P. Rocha

  2. Eli Lilly and Company do Brasil, Av. Morumbi 8264, São Paulo, SP, 04703-002, Brazil

    Arthur Kummer

  3. Unidade de Distúrbios do Movimento, Hospital das Clínicas, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena 110, Belo Horizonte, MG, CEP 30130-100, Brazil

    Francisco E. Cardoso

  4. Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), 1941 East Road, BBSB 3270, Houston, TX, 77054, USA

    Antonio L. Teixeira & Natalia P. Rocha

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  1. Bruno T. Junho
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  2. Arthur Kummer
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  3. Francisco E. Cardoso
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  4. Antonio L. Teixeira
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  5. Natalia P. Rocha
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Correspondence to Natalia P. Rocha.

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All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare that they have no conflict of interest.

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Junho, B.T., Kummer, A., Cardoso, F.E. et al. Sleep quality is associated with the severity of clinical symptoms in Parkinson’s disease. Acta Neurol Belg 118, 85–91 (2018). https://doi.org/10.1007/s13760-017-0868-6

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  • DOI: https://doi.org/10.1007/s13760-017-0868-6

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