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The evaluation of a new marker of transmyocardial repolarization parameters in ischemic stroke patients; T peak–T end (T p-e), T p-e/QTc

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Abstract

The cardiovascular manifestations of acute ischemic stroke have been well known. Several electrocardiography (ECG) abnormalities have been reported in patients following acute stroke, including QT interval prolongation, ST segment deviation and T-wave changes. This study aimed to investigate the changes in transmyocardial repolarization parameters, in ischemic stroke patients. The study is a prospective, blind, and controlled clinical study. The patients without cardiac disease who received ischemic stroke diagnoses were included in the study. ECG was received from the patients in the first hour and 72 h. The P, QT, T p-e, T p-e dispersion, and the T p-e/QT ratio were calculated. Moreover, fifty-five stroke patients and 35 control subjects were included to the study. All dispersion values and T p-e/QTc ratio in patients group were higher than those of control group (p < 0.05 for all values). When evaluated between ECGs’ on first and third days, it was found that decreasing on all dispersion values and T p-e/QTc ratio in ECGs on third day than ECGs on first day (p < 0.05 for all values). QT, QTc, and T p-e dispersions values in patients who have insular lobe involvement were higher than those of patients who do not have insular lobe involvement (p < 0.001 for all values). In this study, we showed that acute stroke increases that P d, QTd, QTcd and new repolarization markers T p-e and T p-e/QTc, during first 24 and 72 h in acute stroke patients without cardiovascular disease compared with the control group. The physicians should be aware about ventricular dysrhythmias in patients with ischemic stroke and these patients closely observed with cardiac monitoring, especially within first 24 h, and especially patients with insular lobe involvement.

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Authors and Affiliations

  1. Department of Emergency Medicine, Keçiören Training and Research Hospital, Pınarbaşı, Sanatoryum Caddesi, Ardahan Sokak, No: 25, 06280, Keçiören, Ankara, Turkey

    Emine Emektar, Şeref Kerem Çorbacıoğlu, Hüseyin Uzunosmanoğlu, Eda Kan & Yunsur Çevik

  2. Department of Neurology, Keçiören Training and Research Hospital, Ankara, Turkey

    Osman Korucu

  3. Department of Radiology, Keçiören Training and Research Hospital, Ankara, Turkey

    Selma Ramadan

Authors
  1. Emine Emektar
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  2. Şeref Kerem Çorbacıoğlu
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  3. Osman Korucu
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  4. Selma Ramadan
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  5. Hüseyin Uzunosmanoğlu
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Correspondence to Emine Emektar.

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Ethics committee at Keçiören Training and Research Hospital approved the study protocol.

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Informed consent was obtained from each patient before entry into the study.

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Emektar, E., Çorbacıoğlu, Ş.K., Korucu, O. et al. The evaluation of a new marker of transmyocardial repolarization parameters in ischemic stroke patients; T peak–T end (T p-e), T p-e/QTc . Acta Neurol Belg 117, 461–467 (2017). https://doi.org/10.1007/s13760-017-0744-4

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  • DOI: https://doi.org/10.1007/s13760-017-0744-4

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