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AS1411 aptamer-functionalized graphene oxide-based nano-carrier for active-target and pH-sensitive delivery of curcumin

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Abstract

A pH-sensitive nano-graphene oxide (nGO)-based delivery system is designed for Cur delivery to MCF cancerous cells. Cur is loaded on the synthesized nGO (Cur-nGO) and decorated by bovine serum albumin (BSA) to improve its biostability, protect the Cur from undesired loss and provide the carboxylic functional groups for aptamer conjunction (Cur-nGO-BSA). Finally, the Cur-nGO-BSA was functionalized with AS1411 aptamer and characterized by various methods. The drug loading and loading efficiency of the designed system are 8.9% and 78.9%, respectively. The loaded drug is preferably released in acidic media at in-vitro studies. The MTT test on MCF7 as positive and SKBR3 as negative nucleolin cancer cells revealed that the Cur-nGO-BSA can inhibit their growth while AS1411 aptamer-functionalized nano-carrier showed an improved efficiency toward MCF7 cells due to the significant affinity of the aptamer toward the highly expressed nucleolin on the MCF7 plasma membrane.

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Authors and Affiliations

  1. Department of Chemistry, Yazd University, Yazd, Iran

    Marzieh Baneshi, Shayessteh Dadfarnia & Ali Mohammad Haji Shabani

  2. Department of Biology, Yazd University, Yazd, Iran

    Seyyed Kazem Sabbagh

  3. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran

    Hassan Bardania

  4. Clinical Research Development Unit, Imamsajad Hospital, Yasuj University of Medical Sciences, Yasuj, Iran

    Hassan Bardania

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  1. Marzieh Baneshi
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  2. Shayessteh Dadfarnia
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  3. Ali Mohammad Haji Shabani
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  4. Seyyed Kazem Sabbagh
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  5. Hassan Bardania
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Correspondence to Shayessteh Dadfarnia.

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Baneshi, M., Dadfarnia, S., Haji Shabani, A.M. et al. AS1411 aptamer-functionalized graphene oxide-based nano-carrier for active-target and pH-sensitive delivery of curcumin. J IRAN CHEM SOC 19, 2367–2376 (2022). https://doi.org/10.1007/s13738-021-02455-x

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