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Recent progress on asymmetric multicomponent reactions via chiral phosphoric acid catalysis

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Abstract

Multicomponent reactions (MCRs) are very important to provide enantiomerically enriched compounds with high structural diversity and complexity. These reactions play an important role in the synthesis of natural products, commercial drugs, agrochemicals and catalysts. Currently, CPA-catalyzed enantioselective MCRs are a hot research topic and promising for the discovery of more complex organic compounds. In this article, the chiral phosphoric acid and CPA metal cooperation catalyzed asymmetric multicomponent reactions derived from BINOL, H8-BINOL, SPA and TADDOL such as the Ugi, Passerini, Biginelli, Povarov and other asymmetric MCRs have been reviewed and summarized. Therefore, in this review, we summarize the recent progress in the developments of CPA and its transition metal-cooperative catalyzed enantioselective multicomponent reactions published from 2015 to date.

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Authors and Affiliations

  1. Department of Chemistry, Bule Hora University, P.O. Box 144, Bule Hora, Ethiopia

    Alemayehu Gashaw

  2. Department of Chemical Engineering, Addis Ababa Science and Technology University (AASTU), P.O. Box 16417, Addis Ababa, Ethiopia

    Dereje Kebebew Debeli

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  1. Alemayehu Gashaw
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Correspondence to Dereje Kebebew Debeli.

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Gashaw, A., Debeli, D.K. Recent progress on asymmetric multicomponent reactions via chiral phosphoric acid catalysis. J IRAN CHEM SOC 19, 1593–1611 (2022). https://doi.org/10.1007/s13738-021-02435-1

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