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Porous Cu(II)-organic framework for solvent-free cyanosilylation and anti-gastric cancer activity by inducing cell apoptosis

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Abstract

A novel metal–organic framework (MOF) containing Cu(II) ions with the chemical formula of {[Cu(L)2(H2O)2](DMF)3}n (1) was successfully prepared by solvothermal reaction method using metal Cu2+ ions as nodes and bifunctional ligand 3-(1H-tetrazol-5-yl)pyridine as organic linker. The activated MOF 1 (1a) could be utilized as catalyst for solvent-free heterogeneous catalytic cyanosilylation reaction because of its open Cu(II) metal positions, and its large amount of nitrogen atoms could be applied as Lewis basic positions. Thus, its catalytic mechanism was also investigated in detail. The specific mechanism was discussed, and its inhibition of the viability of MGC-803 gastric cancer cells was assessed. First, cell counting kit-8 assay was performed to determine the anti-cancer effect of compound 1a against the viability of MGC-803 cells. Then, Annexin V-fluorescein isothiocyanate/propidium iodide method was implemented to determine the percentage of apoptotic MGC-803 cells. Finally, the accumulation of reactive oxygen species in MGC-803 cells treated with the compound was determined via dichloro-dihydro-fluorescein diacetate assay.

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Authors and Affiliations

  1. Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, The Second Affiliated Hospital, Cancer Institute, Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, China

    Shi-Jie Fan & Ren Sun

  2. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA

    Ren Sun

  3. Department of Chemistry, Inner Mongolia University, Tongliao, Inner Mongolia, China

    Di Li & Yang Liu

Authors
  1. Shi-Jie Fan
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  2. Ren Sun
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  3. Di Li
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  4. Yang Liu
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Correspondence to Ren Sun.

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Fan, SJ., Sun, R., Li, D. et al. Porous Cu(II)-organic framework for solvent-free cyanosilylation and anti-gastric cancer activity by inducing cell apoptosis. J IRAN CHEM SOC 17, 2855–2865 (2020). https://doi.org/10.1007/s13738-020-01964-5

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  • DOI: https://doi.org/10.1007/s13738-020-01964-5

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