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Ultrasound aided solvent-free synergy: an improved synthetic approach to access 3,4-dihydropyrimidin-2(1H)-ones

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Abstract

A remarkably simple synthetic method has been described for the access of structurally diverse 3,4-dihydropyrimidin-2(1H)-ones in excellent yields in the presence of 2,4,6-trichloro-1,3,5-triazine (TCT) as an efficient source of hydrochloric acid under ultrasound radiation. In this tandem reaction, a range of aldehydes, β-diketo esters and urea were made to condense together via one-pot, solvent-free synthetic strategy. Use of metal-free catalyst, readily accessible substrates, high production rate and ease of work-up are the imperative features of this protocol.

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Fig. 1
Scheme 1
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Fig. 3
Scheme 2

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Acknowledgements

R. Ramesh (IF120729) gratefully thank the financial assistance from Department of Science and Technology (Grant No: DST/INSPIRE Fellowship/2012/690) New Delhi, India.

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Authors and Affiliations

  1. Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu, 636011, India

    Rathinam Ramesh, Samikannu Ramesh & Appaswami Lalitha

  2. Department of Crystallography, University of Silesia, Szkolna 9, 40-007, Katowice, Poland

    Jan Grzegorz Malecki

Authors
  1. Rathinam Ramesh
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  2. Samikannu Ramesh
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  3. Jan Grzegorz Malecki
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  4. Appaswami Lalitha
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Correspondence to Appaswami Lalitha.

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Ramesh, R., Ramesh, S., Malecki, J.G. et al. Ultrasound aided solvent-free synergy: an improved synthetic approach to access 3,4-dihydropyrimidin-2(1H)-ones. J IRAN CHEM SOC 16, 1197–1205 (2019). https://doi.org/10.1007/s13738-019-01597-3

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