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A novel one-pot three-component approach to 4-amino-functionalized spiropyrimidine-2-thiones

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Abstract

A series of 4-amino-functionalized spiropyrimidine-2-thione derivatives were simply produced by the one-pot three-component reaction of alicyclic carbonyl compounds, nitriles containing an acidic methylene, and thiourea in the presence of NaOMe in MeOH.

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Acknowledgements

We are grateful to the University of Isfahan research council for financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, University of Isfahan, Azadi Sq., Hezarjarib St., Isfahan, 81746-73441, Iran

    Hassan Zali-Boeini, Farzaneh Karimi, Zohreh Khayat, Hadi Amiri Rudbari & Abolghasem Abbasi

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  1. Hassan Zali-Boeini
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  2. Farzaneh Karimi
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  3. Zohreh Khayat
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  4. Hadi Amiri Rudbari
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  5. Abolghasem Abbasi
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Correspondence to Hassan Zali-Boeini.

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Zali-Boeini, H., Karimi, F., Khayat, Z. et al. A novel one-pot three-component approach to 4-amino-functionalized spiropyrimidine-2-thiones. J IRAN CHEM SOC 16, 1139–1146 (2019). https://doi.org/10.1007/s13738-018-01589-9

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  • DOI: https://doi.org/10.1007/s13738-018-01589-9

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