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SO3H-functionalized MCM-41 as an efficient catalyst for the combinatorial synthesis of 1H-pyrazolo-[3,4-b]pyridines and spiro-pyrazolo-[3,4-b]pyridines

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Abstract

Sulfonic acid-functionalized (SO3H-functionalized) mesoporous MCM-41 catalyst was synthesized by anchoring 3-((3-(trimethoxysilyl)propyl)thio)propane-1-sulfonic acid onto MCM-41-type silica and characterized by FT-IR spectroscopy, elemental analysis and scanning electron microscopy (SEM) techniques. The catalyst was used for the efficient multi-component synthesis of 1H-pyrazolo-[3,4-b]pyridines and spiro-pyrazolo-[3,4-b]pyridines. Notably, the catalyst could be recycled and reused with negligible loss in activity over seven cycles.

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Acknowledgements

The authors are grateful to the Centre of Excellence of Chemistry and Research Council of the University of Isfahan for financial support of this work.

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Authors and Affiliations

  1. Catalysis Division, Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran

    Shirin Safaei, Iraj Mohammadpoor-Baltork, Ahmad Reza Khosropour, Majid Moghadam, Shahram Tangestaninejad & Valiollah Mirkhani

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  1. Shirin Safaei
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  2. Iraj Mohammadpoor-Baltork
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  3. Ahmad Reza Khosropour
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  4. Majid Moghadam
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Correspondence to Iraj Mohammadpoor-Baltork or Ahmad Reza Khosropour.

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Safaei, S., Mohammadpoor-Baltork, I., Khosropour, A.R. et al. SO3H-functionalized MCM-41 as an efficient catalyst for the combinatorial synthesis of 1H-pyrazolo-[3,4-b]pyridines and spiro-pyrazolo-[3,4-b]pyridines. J IRAN CHEM SOC 14, 1583–1589 (2017). https://doi.org/10.1007/s13738-017-1099-8

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