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Synthesis and characterization of chitosan coating of NiFe2O4 nanoparticles for biomedical applications

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Abstract

Nickel ferrite nanoparticle is a soft magnetic material whose appealing properties as well as various technical applications have rendered it as one of the most attractive class of materials; its technical applications range from its utility as a sensor and catalyst to its utility in biomedical processes. The present paper focuses first on the synthesis of NiFe2O4 nanoparticles through co-precipitation method resulting in calcined nanoparticles that were achieved at different times and at a constant temperature (773 k). Afterward, they were dispersed in water that was mixed by chitosan. Chitosan was bonded on the surface of nanoparticles by controlling the pH of media. In order to assess the structural and magnetic properties of nanoparticles, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM) analyses were conducted at room temperature. As per the results of XRD analysis, the pure NiFe2O4 was synthesized. Additionally, nanoparticles grew in size by extending the calcination process duration. TEM micrographs were used to determine the size and shape of particle; the obtained results indicate that the particle size was in a range of 17–30 nm and of a circular shape. The proper chitosan covering was also indicated by FTIR results. The VSM analysis also revealed that the saturated magnetization of NiFe2O4 nanoparticles stood in a range of 29 emu/g and 45 Qe. A stable maximum temperature ranging from 30 to 42 was successfully achieved within 10 min. Also, a specific absorption rate of up to 8.4 W/g was achieved. The study results revealed that the SAR parameter of the coated nickel ferrite nanoparticle is more than that of pure nickel ferrite or cobalt ferrite nanoparticles.

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Notes

  1. Caution: aqua regia is an extremely toxic chemical and should be handled with care!

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Acknowledgments

I would like to take this opportunity to express my deepest gratitude for the support that I have received during these past years. Special thanks to Nano System Pars Co (NATSYCO) for manufacturing the device (hyperthermia test) that is crucial in this work.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Saeid Ramezani

  2. Department of Mining and Metallurgical Engineering, Amirkabir University of Technology, Tehran, Iran

    Arash Ghazitabar

  3. Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran

    Sayed Khatiboleslam Sadrnezhaad

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  1. Saeid Ramezani
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  2. Arash Ghazitabar
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  3. Sayed Khatiboleslam Sadrnezhaad
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Correspondence to Arash Ghazitabar.

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Ramezani, S., Ghazitabar, A. & Sadrnezhaad, S.K. Synthesis and characterization of chitosan coating of NiFe2O4 nanoparticles for biomedical applications. J IRAN CHEM SOC 13, 2069–2076 (2016). https://doi.org/10.1007/s13738-016-0924-9

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  • DOI: https://doi.org/10.1007/s13738-016-0924-9

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