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Application of a sensitive nanocomposite-based electrochemical sensor for voltammetric determination of dicyclomine hydrochloride in real samples

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Abstract

In the present study a glassy carbon electrode, modified with nanocomposite of gold nanoparticles/multiwalled carbon nanotubes (GNPs/MWCNTs/GCE), was used for determination of dicyclomine hydrochloride (DcCl). The results showed that synergetic effects of GNPs and MWCNTs highly improved electrochemical response and sensitivity of the sensor. The electrochemical oxidation of DcCl was investigated by cyclic voltammetry and differential pulse voltammetry. Also, scanning electron microscopy and energy dispersive x-ray spectroscopy were used to evaluate microstructure of electrochemical sensor. The effect of various experimental parameters including pH and scan rate on the voltammetric response of DcCl were investigated. Under the optimal conditions linear response was observed in range of 1.0–1.2 × 102 µmol L−1 for DcCl. The lower detection limit was found to be 0.40 µmol L−1 for DcCl. The investigated method showed good stability, reproducibility and repeatability. The proposed sensor was successfully applied to the determination of DcCl in real samples.

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References

  1. H. Ibrahim, Y.M. Issa, M. Hazem, Abu-shawish. Anal. Sci. 20, 911 (2004)

    Article  CAS  Google Scholar 

  2. L.I. Bebawy, Y.M. Issa, K.M. Abdelmoneim, J. Assoc. Off. Anal. Chem. 86, 1 (2003)

    CAS  Google Scholar 

  3. T. Sireesha, K. Shantakumari, R.V. Durgasai, K. Sudhanaik, J. Pharm. Res. 3, 1584 (2014)

    CAS  Google Scholar 

  4. A.D. Kale, S.J. Kachhwaha, G.P. Jadhav, P. Trivedi, Indian Drugs 35, 718 (1998). ISSN 0019-462X CODEN INDRBA

  5. M.A. Raggi, V. Cavrini, A.M. Di Pietra, J. Pharm. Biomed. Anal. 3, 287 (1985)

    Article  CAS  Google Scholar 

  6. G.M. Hanna, J. Assoc. Off. Anal. Chem. 67, 222 (1984)

    CAS  Google Scholar 

  7. B.J. Walker, J.F. Lang, R.A. Okerholm, J. Chromatogr. B 416, 150 (1987)

    Article  CAS  Google Scholar 

  8. K.J. Huang, D.F. Luo, W.Z. Xie, Y.S. Yu, Colloids Surf. B 61, 176 (2008)

    Article  CAS  Google Scholar 

  9. D. Chen, L.H. Tang, J.H. Li, Chem. Soc. Rev. 39, 3157 (2010)

    Article  CAS  Google Scholar 

  10. J.H. Shim, Y. Lee, M. Kang, J. Lee, J.M. Baik, Y. Lee, C. Lee, M.H. Kim, Anal. Chem. 84, 3827 (2012)

    Article  CAS  Google Scholar 

  11. D.R. Jeykumari, S.S. Narayanan, Carbon 47, 957 (2009)

    Article  CAS  Google Scholar 

  12. A. Afkhami, T. Madrakian, H. Ghaedi, H. Khanmohammadi, Electrochim. Acta 66, 255 (2012)

    Article  CAS  Google Scholar 

  13. V. Arabali, M. Ebrahimi, M. Abbasghorbani, V. Kumar Gupta, M. Farsi, M.R. Ganjali, F. Karimi, J. Mol. Liq. 213, 312 (2016)

    Article  CAS  Google Scholar 

  14. A. Afkhami, S. Sayari, F. Soltani-Felehgari, T. Madrakian, J. Iran. Chem. Soc. 12, 257 (2015)

    Article  CAS  Google Scholar 

  15. G. Karim-Nezhad, S. Pashazadeh, J. Iran. Chem. Soc. 13, 307 (2016)

    Article  CAS  Google Scholar 

  16. M. Mazloum-Ardakani, H. Beitollahi, M. Kazem Amini, F. Mirkhalaf, M. Abdollahi-Alibeik, Sens. Actuator B 151, 243 (2010)

  17. A. Afkhami, A. Bahiraei, T. Madrakian, Mater. Sci. Eng. C 59, 168 (2016)

    Article  CAS  Google Scholar 

  18. T.L. Lu, Y.C Tsai, Sens. Actuator B 153, 439 (2011)

  19. O. Akhavan, E. Ghaderi, R. Rahighi, ACS Nano 6, 2904 (2012)

    Article  CAS  Google Scholar 

  20. O. Akhavan, E. Ghaderi, R. Rahighi, M. Abdolahad, Carbon 79, 654 (2014)

    Article  CAS  Google Scholar 

  21. K. Sarhangzadeh, J. Iran. Chem. Soc. 12, 2133 (2015)

    Article  CAS  Google Scholar 

  22. W. Huang, W. Qian, P. Jain, M. El-Sayed, Nano Lett. 7, 3227 (2007)

    Article  CAS  Google Scholar 

  23. O.P. Khatri, K. Murase, H. Sugimura, Langmuir 24, 3787 (2008)

    Article  CAS  Google Scholar 

  24. A. Afkhami, F. Soltani-Felehgari, T. Madrakian, Talanta 128, 203 (2014)

    Article  CAS  Google Scholar 

  25. N.F. Atta, A. Galal, F.M. Abu-Attia, S.M. Azab, J. Electrochem. Soc. 157, 116 (2010)

    Article  Google Scholar 

  26. Z.F. Chen, Y. Zu, Langmuir 23, 11387 (2007)

    Article  CAS  Google Scholar 

  27. H. Qiu, G. Zhou, G. Ji, Y. Zhang, X. Huang, Y. Ding, Colloids Surf. B 69, 105 (2009)

    Article  CAS  Google Scholar 

  28. A. Afkhami, F. Soltani-Felehgari, T. Madrakiana, H. Ghaedi, Biosens. Bioelectron. 51, 379 (2014)

    Article  CAS  Google Scholar 

  29. T. Madrakian, E. Haghshenas, A. Afkhami, Sens. Actuators B 193, 451 (2014)

    Article  CAS  Google Scholar 

  30. Z.A. Alothmana, N. Bukharia, S.M. Wabaidura, S. Haider, Sens. Actuators B 146, 314 (2010)

    Article  Google Scholar 

  31. P. Daneshgar, P. Norouzi, A.A. Moosavi-Movahedi, M.R. Ganjali, E. Haghshenas, F. Dousty, M. Farhadi, J. Appl. Electrochem. 39, 1983 (2009)

    Article  CAS  Google Scholar 

  32. J. Li, H. Xie, L. Chen, Sens. Actuators B 153, 239 (2011)

    Article  CAS  Google Scholar 

  33. F. Yang, Q. Xie, H. Zhang, S. Yu, X. Zhang, Y. Shen, Sens. Actuators B 210, 232 (2015)

    Article  CAS  Google Scholar 

  34. A. Afkhami, A. Bahiraei, T. Madrakian, Mater. Sci. Eng. C 59, 168 (2016)

    Article  CAS  Google Scholar 

  35. M.P. Deepak, G.P. Mamatha, Int. J. Pharm. Chem. 5, 21 (2015)

    Google Scholar 

  36. H. Ibrahim, Y.M. Issa, H.M. Abu-shawish, Anal. Chim. Acta 532, 79 (2005)

    Article  CAS  Google Scholar 

  37. M. Raghunath, A. Dhamne, V. Mistry, V. Bhaskar, J. Pharm. Pharm. Sci. 4, 1117 (2015)

    CAS  Google Scholar 

  38. M.H. Bachani, D.S. Acharya, K.V. Shah, Int. J. Pharm. Pharm. Sci. 5, 462 (2013)

    CAS  Google Scholar 

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Acknowledgments

The authors acknowledge the Bu-Ali Sina University Research Council and Center of Excellence in Development of Environmentally Friendly Methods for Chemical Synthesis (CEDEFMCS) for providing support to this work.

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Authors and Affiliations

  1. Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran

    Tayyebeh Madrakian, Somayeh Maleki & Abbas Afkhami

Authors
  1. Tayyebeh Madrakian
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  2. Somayeh Maleki
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  3. Abbas Afkhami
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Correspondence to Tayyebeh Madrakian.

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Madrakian, T., Maleki, S. & Afkhami, A. Application of a sensitive nanocomposite-based electrochemical sensor for voltammetric determination of dicyclomine hydrochloride in real samples. J IRAN CHEM SOC 13, 1819–1825 (2016). https://doi.org/10.1007/s13738-016-0899-6

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  • DOI: https://doi.org/10.1007/s13738-016-0899-6

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