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The application of magnetic nano graphene oxide in determination of methamphetamine by high performance liquid chromatography of urine samples

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Abstract

In this study, a novel method was reported for the extraction of methamphetamine from urine samples using magnetic solid phase extraction (MSPE) technique. Magnetic nano graphene oxide (MNGO) was synthesized and applied as a new adsorbent for the extraction of methamphetamine from urine samples. The successful synthesis of MNGO was confirmed by Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), powder X-ray diffraction (XRD) and vibrating sample magnetometer (VSM). The main factors (the amounts of sample volume, amount of adsorbent, type and amount of extraction organic solvent, time of extraction and desorption, pH, the ionic strength of extraction medium, and agitation rate) influencing the extraction efficiency were investigated and optimized. Under optimized extraction conditions, a good linearity was observed in the range of 100–1500 ng mL−1 with the correlation coefficient of 0.9973 (r 2). Limit of detection (LOD) and Limit of quantification (LOQ) were 30 and 100 ng mL−1, respectively. The inter-day and intra-day precisions were within 8.18 and 9.21 %, respectively. The inter-day and intra-day biases were −0.39 and −0.44 %, respectively. The recovery of spiked samples was 91.76 %. The method was applied for determination of methamphetamine in abused drug urine samples with the recovery of 93.47 %. It was concluded that the proposed method can be applied in forensic clinics for the determination of methamphetamine in addicted subjects.

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Acknowledgments

Drug Applied Research Center of Tabriz University of Medical Science is greatly appreciated for supporting the study.

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Authors and Affiliations

  1. Department of Chemistry, Mashhad branch, Islamic Azad University, Mashhad, Iran

    Arezou Taghvimi & Mahmoud Ebrahimi

  2. Drug Applied Research Centre, Tabriz University of Medical science, Tabriz, Iran

    Hamed Hamishehkar

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  1. Arezou Taghvimi
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  2. Hamed Hamishehkar
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  3. Mahmoud Ebrahimi
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Correspondence to Hamed Hamishehkar or Mahmoud Ebrahimi.

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Taghvimi, A., Hamishehkar, H. & Ebrahimi, M. The application of magnetic nano graphene oxide in determination of methamphetamine by high performance liquid chromatography of urine samples. J IRAN CHEM SOC 13, 1471–1480 (2016). https://doi.org/10.1007/s13738-016-0862-6

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  • DOI: https://doi.org/10.1007/s13738-016-0862-6

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