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Two acute kidney injury episodes after ICI therapy: a case report

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A Correction to this article was published on 24 April 2024

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Abstract

A 74-year-old Japanese male with lung squamous cell carcinoma received his first dose of immune checkpoint inhibitors (ICIs): ipilimumab and nivolumab. He developed acute kidney injury (AKI) and was admitted to our department. We diagnosed kidney immune-related adverse effects (irAE), and a kidney biopsy revealed acute tubulointerstitial nephritis. We started oral prednisolone (PSL) and his AKI immediately improved. The patient maintained stable findings after PSL was tapered off. However, seven months after the ICI administration, he developed rapid progressive glomerular nephritis and was admitted to our department again. The second kidney biopsy showed findings consistent with anti-glomerular basement membrane glomerulonephritis. Although the patient was treated with pulse methylprednisolone followed by oral PSL and plasma exchange, he became dependent on maintenance hemodialysis. To our knowledge, no case report has described two different types of biopsy-proven nephritis. In cases of suspected relapsing kidney irAEs, both a relapse of previous nephritis and the development of another type of nephritis should be considered.

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Authors and Affiliations

  1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, Yokohama, 236-0004, Japan

    Kohei Ishiga, Ryu Kobayashi, Tomohiko Kanaoka, Hiromichi Wakui, Yoshiyuki Toya & Kouichi Tamura

  2. Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Jotaro Harada, Ikuma Kato & Satoshi Fujii

Authors
  1. Kohei Ishiga
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  2. Ryu Kobayashi
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  3. Tomohiko Kanaoka
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  4. Jotaro Harada
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  5. Ikuma Kato
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  6. Satoshi Fujii
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  7. Hiromichi Wakui
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  8. Yoshiyuki Toya
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  9. Kouichi Tamura
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Correspondence to Ryu Kobayashi.

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The original online version of this article was revised:In the original publication, the text content/characters in the x-axis and y-axis of fig 3 has been inadvertently missed out.

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Ishiga, K., Kobayashi, R., Kanaoka, T. et al. Two acute kidney injury episodes after ICI therapy: a case report. CEN Case Rep (2024). https://doi.org/10.1007/s13730-024-00855-5

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