Abstract
Karyomegalic interstitial nephritis is a singular type of progressive chronic interstitial nephritis. The pathogenesis of this disease is unknown. The present study reported the case of a 22-year-old man who presented with a long history of recurrent upper respiratory tract infection episodes secondary to bronchiectasis and with progressive renal failure. Renal biopsy revealed chronic tubulointerstitial nephritis and a surprisingly marked karyomegaly specifically of the tubular epithelium.
Similar content being viewed by others
References
Burry AF. Extreme dysplasia in renal epithelium of a young woman dying from hepatocarcinoma. J Pathol. 1974;113:147–50.
Mihatsch MJ, Gudat F, Zollinger HU, et al. Systemic karyomegaly associated with chronic interstitial nephritis. A new disease entity? Clin Nephrol. 1979;12(2):54–62.
Bhandari S, Kalowski S, Collett P, et al. Karyomegalic nephropathy: an uncommon cause of progressive renal failure. Nephrol Dial Transplant. 2002;17(11):1914–20.
Uz E, Bayram Y, Haltas H, Bavbek N, Kanbay M, Guz G, et al. Karyomegalic tubulointerstitial nephritis: a rare cause of chronic kidney disease. Nephrourol Mon. 2011;3:201–3.
Hassen W, Abid-Essafi S, Achour A, et al. karyomegaly of tubular kidney cells in human chronic interstitial nephropathy in Tunisia: respective role of ochratoxin A and possible genetic predisposition. Hum Exp Toxicol. 2004;23:339–46.
McCulloch T, Prayle A, Lunn A, Watson AR. Karyomegalic-like nephropathy, Ewing’s sarcoma and ifosfamide therapy. Pediatr Nephrol. 2011;26:1163–6.
Matsuura T, Wakino S, Yoshifuji A, et al. Improvement in karyomegalic interstitial nephritis three years after ifosfamide and cisplatin therapy by corticosteroid. CEN Case Rep. 2014;3:226–31.
Spoendlin M, Moch H, Brunner F, et al. Karyomegalic interstitial nephritis: further support for a distinct entity and evidence for a genetic defect. Am J Kidney Dis. 1995;25:242–52.
Godin M, Franck Le Roy A, Morin J-P, et al. Karyomegalic interstitial nephritis. Am J Kidney Dis. 1996;27(1):166.
Conflict of interest
The authors declare that they have no conflicts of interest.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Bennani Guebessi, N., Karkouri, M. Karyomegalic interstitial nephritis. CEN Case Rep 5, 23–25 (2016). https://doi.org/10.1007/s13730-015-0183-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13730-015-0183-0