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Primary adenocarcinoma of the rete testis with elevated serum CA19-9 antigen levels

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Abstract

Primary adenocarcinoma of the rete testis is an extremely rare tumor with a poor prognosis. Herein, we report a case of primary adenocarcinoma of the rete testis accompanied by elevated serum carbohydrate antigen 19-9 (CA19-9) antigen levels in a 44-year-old man who presented with left scrotal swelling. Para-aortic lymph node swelling was observed on the computed tomography scan. Germ cell tumor markers were within the normal range, but serum CA19-9 antigen levels were high. Radical orchiectomy was performed, and histological examination revealed primary adenocarcinoma of the rete testis with no evidence of other primary carcinomas. The patient underwent three lines of chemotherapy, although no reports suggest the use of gemcitabine and oxaliplatin (GEMOX) in a patient with adenocarcinoma of the rete testis. Unfortunately, he developed metastasis at multiple sites and passed away due to adenocarcinoma 13 months after undergoing orchiectomy. Some reports suggest that CA19-9 antigen levels are elevated in patients with adenocarcinoma of the rete testis, although it has not been clarified whether elevated CA19-9 antigen levels reflect the progression of adenocarcinoma of the rete testis. In this case, as CA19-9 antigen levels increased with progression, CA19-9 might be a marker for primary adenocarcinoma of the rete testis. GEMOX chemotherapy as a line of treatment in primary adenocarcinoma of the rete testis has not been reported. Therefore, further studies must evaluate the efficacy of the aforementioned chemotherapy regimen.

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References

  1. Feek JD, Hunter WC (1945) Papillary carcinoma arising from rete testis. Arch Pathol 40:399–402

    CAS  Google Scholar 

  2. Nakagawa T, Hiraoka N, Ihara F et al (2006) Primary adenocarcinoma of the rete testis with preceding diagnosis of pulmonary metastases. Int J Urol 13:1532–1535

    Article  Google Scholar 

  3. Al-Obaidy KI, Idrees MT, Grignon DJ et al (2019) Adenocarcinoma of the rete testis: clinicopathologic and immunohistochemical characterization of 6 cases and review of the literature. Am J Surg Pathol 43:670–681

    Article  Google Scholar 

  4. Sanchez-Chapado M, Angulo JC, Haas GP (1995) Adenocarcinoma of the rete testis. Urology 46:468–475

    Article  CAS  Google Scholar 

  5. Orozco RE, Murphy WM (1993) Carcinoma of the rete testis: case report and review of the literature. J Urol 150:974–977

    Article  CAS  Google Scholar 

  6. Huang PW, Chang KM (2015) Adenocarcinoma of the rete testis with prominent papillary structure and clear neoplastic cells: morphologic and immunohistochemical findings and differential diagnosis. Indian J Pathol Microbiol 58:232–234

    Article  Google Scholar 

  7. Takeda S, Yamashita S, Kawamorita N et al (2017) Primary adenocarcinoma of the rete testis with elevation of serum carcinoembryonic antigen: a case report. Int Cancer Conf J 6:84–88

    Article  Google Scholar 

  8. Okada H, Hanioka K, Fujisawa M et al (1997) Primary adenocarcinoma of the rete testis. Br J Urol 79:300–302

    Article  CAS  Google Scholar 

  9. Maganty A, Fombona A, Bandari J et al (2018) Aggressive surgical management of adenocarcinoma oh the rete testis. Urol Case Rep 16:72–74

    Article  Google Scholar 

  10. Rubegni P, Poggiali S, De Santi M et al (2006) Cutaneous metastases from adenocarcinoma of the rete testis. J Cutan Pathol 33:181–184

    Article  Google Scholar 

  11. Chovanec M, Mego M, Sycova-Mila Z et al (2014) Adenocarcinoma of the rete testis: a rare case of testicular malignancy. Klin Onkol 27:136–137

    Article  CAS  Google Scholar 

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Acknowledgements

We thank the members of the division of clinical and molecular genetics, Hiroshima university hospital.

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Authors and Affiliations

  1. Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3 Minamiku, Hiroshima City, Hiroshima, 734-8551, Japan

    Hiroyuki Kitano, Keisuke Goto, Yohei Sekino, Ryoken Yamanaka, Keiji Nagasaka, Tetsutaro Hayashi & Jun Teishima

  2. Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

    Kazuhiro Sentani & Wataru Yasui

  3. Department of Urology, Chugoku Rosai Hospital, Kure City, Japan

    Yoshinori Shigematsu & Kanao Kobayashi

Authors
  1. Hiroyuki Kitano
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  2. Kazuhiro Sentani
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  3. Keisuke Goto
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  4. Yohei Sekino
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  5. Ryoken Yamanaka
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  6. Keiji Nagasaka
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  7. Yoshinori Shigematsu
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  8. Kanao Kobayashi
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  9. Tetsutaro Hayashi
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  10. Wataru Yasui
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  11. Jun Teishima
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Contributions

HK contributed to the conception and design of this report and wrote the first draft of the manuscript. KS, KG, YS, RY, KN, YS, KK, TH, WY and JT critically reviewed the manuscript and supervised the research. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Hiroyuki Kitano.

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Kitano, H., Sentani, K., Goto, K. et al. Primary adenocarcinoma of the rete testis with elevated serum CA19-9 antigen levels. Int Canc Conf J 9, 240–243 (2020). https://doi.org/10.1007/s13691-020-00437-z

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  • DOI: https://doi.org/10.1007/s13691-020-00437-z

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