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Pseudomonas—Spectrum of Disease Presentations for the Inpatient Dermatologist

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Abstract

Purpose of Review

Pseudomonas aeruginosa-associated cutaneous dermatoses are reasons for consultation for the inpatient dermatologist. This review provides an overview of the spectrum of Pseudomonas-associated cutaneous diseases that may present in the inpatient setting along with the diagnostic work-up and clinical management.

Recent Findings

Pseudomonas aeruginosa infections are an ongoing healthcare concern due to its intrinsic and acquired antimicrobial resistance. The rising incidence of multi-drug resistant P. aeruginosa strains has led to the prioritization and development of effective drugs with increased efforts towards antibiotic stewardship. Diagnostic and clinical management for P. aeruginosa infections include blood and tissue culture and, in immunocompromised or severely ill patients, the use of 2 antipseudomonal agents with de-escalation once the culture and antibiotic susceptibilities become available.

Summary

Pseudomonas aeruginosa is frequently considered among the differential diagnosis of causative pathogens in inpatient cutaneous infections, most importantly due to its associated high morbidity and mortality. The disease presentation spans various anatomical locations, and the clinical course may be difficult to manage due to antibiotic resistance. Clinicians should be familiar with the spectrum of disease presentations as well as the appropriate diagnostic work-up and management strategies.

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Abbreviations

EG:

Ecthyma gangrenosum

CAR:

Cutaneous adverse reaction

NEH:

Neutrophilic eccrine hidradenitis

PA:

Pseudomonas aeruginosa

POU:

Point-of-use

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Authors and Affiliations

  1. Department of Dermatology, Feinberg School of Medicine, Northwestern University, 676 N St Clair St Ste 1600, Chicago, IL, 60611-2941, USA

    Yae Kye & Cuong V. Nguyen

  2. Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Grant Zhao

  3. Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA

    Yae Kye

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Kye, Y., Zhao, G. & Nguyen, C.V. Pseudomonas—Spectrum of Disease Presentations for the Inpatient Dermatologist. Curr Derm Rep 12, 115–124 (2023). https://doi.org/10.1007/s13671-023-00391-y

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  • DOI: https://doi.org/10.1007/s13671-023-00391-y

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