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Skin Barrier Function and Atopic Dermatitis

  • Atopic Dermatitis (C Vestergaard, Section Editor)
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Abstract

Purpose of Review

The purpose of this review was to highlight the importance of the skin barrier in the development of atopic dermatitis (AD).

Recent Findings

Skin barrier function relies on the stratum corneum (SC) and tight junction. These components are deranged in the AD epidermis. Deficiency in filaggrin gives rise to abnormal epidermal integrity. The intercellular lipid composition, ratio, and organization are found to be disturbed. Keratinocyte shedding from the SC is also impaired. Tight junction proteins are reduced and result in sweat leakage into the skin surface.

Summary

Strategies to enhance skin barrier strength will alleviate AD symptoms and may prevent the disease.

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Acknowledgements

The author, PR, thanks the Skin and Allergy Research Unit of Chulalongkorn University for their support.

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  1. Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawara, Sakyo, Kyoto, 606-8507, Japan

    Pawinee Rerknimitr, Atsushi Otsuka, Chisa Nakashima & Kenji Kabashima

  2. Division of Dermatology, Department of Medicine, Faculty of Medicine, The Skin and Allergy Research Unit, Chulalongkorn University, Bangkok, Thailand

    Pawinee Rerknimitr

  3. Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore

    Kenji Kabashima

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  1. Pawinee Rerknimitr
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Rerknimitr, P., Otsuka, A., Nakashima, C. et al. Skin Barrier Function and Atopic Dermatitis. Curr Derm Rep 7, 209–220 (2018). https://doi.org/10.1007/s13671-018-0232-y

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