Abstract
Purpose of Review
Epilepsy, particularly new onset, disproportionately affects the elderly at high rates. We summarize the literature on etiologic risk factors and the evidence behind medical and surgical treatments for geriatric epilepsy.
Recent Findings
Incident epilepsy in the elderly is most commonly focal onset resulting from structural brain disease. Levetiracetam was well tolerated and as effective as older medications for new onset seizures. Small studies on epilepsy surgery show favorable outcomes in older patients; however, surgery may be associated with an increased risk of cognitive deficits and complications.
Summary
Further studies are needed to examine the utility of newer antiepileptic medications in the elderly. In particular, the selection of a good surgical candidate in this age group requires more detailed investigation.
Similar content being viewed by others
References
Papers of particular interest, published recently, have been highlighted as: • Of importance
IOM (Institute of Medicine). Epilepsy across the spectrum: promoting health and understanding. Washington, DC: The National Academies Press; 2012.
Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475–82. https://doi.org/10.1111/epi.12550.
Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia. 1993;34(3):453–68. https://doi.org/10.1111/j.1528-1157.1993.tb02586.x.
Hussain SA, Haut SR, Lipton RB, Derby C, Markowitz SY, Sinnar S. Incidence of epilepsy in a racially diverse, community-dwelling, elderly cohort: results from the Einstein aging study. Epilepsy Res. 2006;71(2–3):195–205. https://doi.org/10.1016/j.eplepsyres.2006.06.018.
• Choi H, Pack A, Elkind MSV, Longstreth WT, Ton TGN, Onchiri F. Predictors of incident epilepsy in older adults. Neurology. 2017;88(9):870–7. https://doi.org/10.1212/WNL.0000000000003662. This recent study analyzed a prospective cohort of older adults ages > 65 years enrolled in the Cardiovascular Health Study, followed annually for 15 years. The investigators found that black race, age 75–79 years, and a history of stroke were predictors of incident epilepsy.
Sands T, Choi H. Genetic testing in pediatric epilepsy. Curr Neurol Neurosci Rep. 2017;17(5):45. https://doi.org/10.1007/s11910-017-0753-y.
Hauser WA. Seizure disorders: the changes with age. Epilepsia. 1992;33(Suppl 4):S6–14. https://doi.org/10.1111/j.1528-1157.1992.tb06222.x.
Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizures types by the international league against epilepsy: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):522–30. https://doi.org/10.1111/epi.13670.
Luders HO. Classification of epileptic seizures and epilepsies. In: Luders HO, editor. Textbook of epilepsy surgery. London: Informa Healthcare; 2008. https://doi.org/10.3109/9780203091708-39.
Hiyoshi T, Yagi K. Epilepsy in the elderly. Epilepsia. 2000;41(Suppl 9):S31–5. https://doi.org/10.1111/j.1528-1157.2000.tb02217.x.
Krumholz A, Wiebe S, Gronseth G, Shinnar S, Levisohn P, Ting T, et al. Practice parameter: evaluating an apparent unprovoked first seizure in adults (an evidence-based review). Neurology. 2007;69(21):1996–2007. https://doi.org/10.1212/01.wnl.0000285084.93652.43.
Krumholz A, Wiebe S, Gronseth G, et al. Evidence-based guideline: management of an unprovoked first seizure in adults. Neurology. 2015;84(16):1705–13. https://doi.org/10.1212/WNL.0000000000001487.
Stefan H, May TW, Plafflin M, et al. Epilepsy in the elderly: comparing clinical characteristics with younger patients. Acta Neurol Scand. 2014;129(5):283–93. https://doi.org/10.1111/ane.12218.
Martin RC, Faught E, Funkhouser E, et al. Psychiatric and neurologic risk factors for incident cases of new-onset epilepsy in older adults: data from U.S. Medicare beneficiaries. Epilepsia. 2014;55(7):1120–7. https://doi.org/10.1111/epi.12649.
Hermann BP, Sidenberg M, Bell B. Psychiatric comorbidity in chronic epilepsy: identification, consequences, and treatment of major depression. Epilepsia. 2000;41(Suppl 2):S31–41. https://doi.org/10.1111/j.1528-1157.2000.tb01522.x.
Josephson CB, Lowerison M, Vallerand I, Sajobi TT, Patten S, Jette N, et al. Association of depression and treated depression with epilepsy and seizure outcomes: a multicohort analysis. JAMA Neurol. 2017;74(5):533–9. https://doi.org/10.1001/jamaneurol.2016.5042.
• Werhahn KJ, Trinka E, Dobesberger J, Unterberger I, Baum P, Deckert-Schmitz M, et al. A randomized, double-blind comparison of antiepileptic drug treatment in the elderly with new-onset focal epilepsy. Epilepsia. 2015;56(3):450–9. https://doi.org/10.1111/epi.12926. This randomized, double-blinded clinical trial enrolled patients ages > 60 years old with new onset focal epilepsy to carbamazepine, lamotrigine, or levetiracetam in order to determine relative tolerability and efficacy over a 1-year follow-up period. They found that levetiracetam was significantly better tolerated than carbamazepine, with lamotrigine not different from either; efficacy was similar for all of them.
Pohlmann-Eden B, Marson AG, Noack-Rink M, Ramirez F, Tofighy A, Werhahn KJ, et al. Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblended KOMET study. BMC Neurol. 2016;16(1):149. https://doi.org/10.1186/s12883-016-0663-7.
Rowan AJ, Ramsay RE, Collins JF, Pryor F, Boardman KD, Uthman BM, et al. New onset geriatric epilepsy: a randomized study of lamotrigine, gabapentin, and carbamazepine. Neurology. 2005;64(11):1868–73. https://doi.org/10.1212/01.WNL.0000167384.68207.3E.
Brodie MJ, Overstall PW, Giorgi L. Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. The UK Lamotrigine Elderly Study Group. Epilepsy Res. 1999;37(1):81–7. https://doi.org/10.1016/S0920-1211(99)00039-X.
Arif H, Bucshbaum R, Pierro J, et al. Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy. Arch Neurol. 2010;67(4):408–15. https://doi.org/10.1001/archneurol.2010.49.
Carcak N, Ozkara C. Seizures and antiepileptic drugs: from pathophysiology to clinical practice. Curr Pharm Des. 2017;23:1–13. https://doi.org/10.2174/1381612823666171115101557.
Gambardella A, Labate A, Mumoli L, et al. Role of pharmacogenomics in antiepileptic drug therapy: current status and future perspectives. Curr Pharm Des. 2017;23:1–6. https://doi.org/10.2174/1381612823666170911111536.
Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med. 2000;342(5):314–9. https://doi.org/10.1056/NEJM200002033420503.
Wiebe S, Blume WT, Girvin JP, Eliasziw M. A randomized, controlled trial of surgery for temporal-lobe epilepsy. N Engl J Med. 2001;345(5):311–8. https://doi.org/10.1056/NEJM200108023450501.
Engel J, McDermott M, Wiebe S, et al. Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. JAMA. 2012;307(9):922–30. https://doi.org/10.1001/jama.2012.220.
d’Orio P, Pelliccia V, Gozzo F, et al. Epilepsy surgery in patients older than 50 years: effectiveness, safety, and predictors of outcome. Seizure. 2017;50:60–6. https://doi.org/10.1016/j.seizure.2017.06.003.
Weiser HG, Blume WT, Fish D, et al. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery. Epilepsia. 2001;42(2):282–6. https://doi.org/10.1046/j.1528-1157.2001.35100.
Thompson PJ, Baxendale SA, McEvoy AW, Duncan JS. Cognitive outcomes of temporal lobe epilepsy surgery in older patients. Seizure. 2015;29:41–5. https://doi.org/10.1016/j.seizure.2015.03.017.
Dewar S, Eliashiv D, Walshaw PD, Engel J Jr, Fried I, Moseley BD. Safety, efficacy, and life satisfaction following epilepsy surgery in patients aged 60 years and older. J Neurosurg. 2016;124(4):945–51. https://doi.org/10.3171/2015.3.JNS142317.
Morris H, Najm I, Kahane P. Epilepsy surgery: patient selection. In: Luders HO, editor. Textbook of epilepsy surgery. London: Informa Healthcare; 2008. https://doi.org/10.3109/9780203091708-36.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
Brad Kamitaki and Hyunmi Choi declare no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
This article is part of the Topical Collection on Neurology of Aging
Rights and permissions
About this article
Cite this article
Kamitaki, B.K., Choi, H. Epilepsy in the Elderly: Risk Factors and Management Approaches. Curr Geri Rep 7, 12–18 (2018). https://doi.org/10.1007/s13670-018-0235-3
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13670-018-0235-3