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Assessing Frailty and Vulnerability in Older Adults with Cancer

  • Hematology and Oncology (GR Williams, Section Editor)
  • Published:
Current Geriatrics Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Aging is associated with decreased physiologic reserve, and older adults are more susceptible to cancer treatment toxicity. In this review, we discuss the implications of frailty and vulnerability in older patients with cancer. We also review a number of instruments that can be used to assess frailty and vulnerability and propose a practical approach to incorporate these tools in a general oncology or geriatric clinic.

Recent Findings

In older patients with cancer, frailty and vulnerability are associated with all-cause mortality, postoperative complications, and treatment intolerance/toxicities. If feasible, a comprehensive geriatric assessment should be used to assess of frailty and vulnerability. If a full geriatric assessment cannot be performed, screening tools such as the Balducci’s criteria, Vulnerable Elders Survey-13, Triage Risk Screening Tool, Groningen Frailty Index, and Geriatric 8 may be used.

Summary

Future studies should evaluate geriatric assessment domains that have the greatest predictive value for toxicity for each cancer type and treatment.

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Authors and Affiliations

  1. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 704, Rochester, NY, 14642, USA

    Kah Poh Loh, Colin McHugh, Supriya G. Mohile & Ronald J. Maggiore

  2. Division of Geriatrics, Palliative Care and Post-Acute Medicine, Baystate Medical Center, Springfield, MA, USA

    Sheryl Ramdass

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Correspondence to Kah Poh Loh.

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Kah Poh Loh, Sheryl Ramdass, Colin McHugh and Ronald Maggiore declare no conflict of interest.

Supriya Mohile reports grants from National Institutes of Health during the conduct of the study and payment as a consultant from Seattle Genetics outside the submitted work.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Loh, K.P., Ramdass, S., McHugh, C. et al. Assessing Frailty and Vulnerability in Older Adults with Cancer. Curr Geri Rep 6, 231–238 (2017). https://doi.org/10.1007/s13670-017-0222-0

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