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Contemporary Treatment Strategies for Rare Epithelial Ovarian Cancers

  • Gynecologic Oncology (A. Fader, Section Editor)
  • Published:
Current Obstetrics and Gynecology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Epithelial ovarian carcinoma consists of not one but five distinct histologic subtypes which include high-grade and low-grade serous carcinomas, clear cell, endometrioid, and mucinous carcinoma. Until recently, women with all histologic subtypes have been “grouped together” in cooperative group trials and treated in a similar fashion.

Recent Findings

Recent advances have demonstrated that each subtype differs in molecular and genetic differentiation, pathogenesis, clinical behavior, and response to treatments. Since the establishment of the Gynecologic Oncology Group (GOG) Rare Tumor Committee in 2005, there has been increasing emphasis placed upon novel treatment strategies for these low incidence malignancies. There has been mounting evidence to suggest that a “one-size-fits-all” treatment approach is not appropriate—especially for low-grade serous, clear cell, endometrioid, and mucinous carcinomas as they all tend to be relatively chemoresistant to typical platinum/taxane-based chemotherapy regimens utilized for high-grade serous carcinomas.

Summary

We present a review of the rare epithelial ovarian cancer subtypes, including current best clinical practices for the management of each tumor type.

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, Kelly Gynecologic Oncology Service, Johns Hopkins Medicine, 600 N. Wolfe St, Phipps 287, Baltimore, MD, 21287, USA

    Jennifer E. Bergstrom & Amanda N. Fader

  2. Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    David M. Gershenson

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  1. Jennifer E. Bergstrom
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Correspondence to Jennifer E. Bergstrom.

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Jennifer E. Bergstrom, Amanda N. Fader, and David M. Gershenson declare that they have no conflict of interest.

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*The editors would like to thank Dr. James Greenberg for taking the time to review this manuscript.

This article is part of the Topical Collection on Gynecologic Oncology

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Bergstrom, J.E., Fader, A.N. & Gershenson, D.M. Contemporary Treatment Strategies for Rare Epithelial Ovarian Cancers. Curr Obstet Gynecol Rep 6, 228–236 (2017). https://doi.org/10.1007/s13669-017-0217-z

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