Abstract
Purpose of Review
The aim of this review is to examine the existing data for risks involved and clinical recommendations for patients with obstructive sleep apnea (OSA) undergoing a surgical procedure.
Recent Findings
In addition to upper airway anatomy, there are non-anatomical endotypes of OSA as well. The response of these endotypes to various perioperative scenarios can be used for targeted, patient-specific intervention. Screening tools should be used for risk stratification. Positive airway pressure therapy remains the treatment of choice. A few patients may require supplemental oxygen.
Summary
Obstructive sleep apnea is associated with an increased risk of perioperative complications. Due to limited research in this area, there remains a paucity of standardized practice guidelines for at risk patient populations.
Similar content being viewed by others
References
Benjafield AV, Ayas NT, Eastwood PR, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med. 2019;7:687–98. https://doi.org/10.1016/S2213-2600(19)30198-5.
Kaw R, Chung F, Pasupuleti V, Mehta J, Gay PC, Hernandez AV. Meta-analysis of the association between obstructive sleep apnoea and postoperative outcome. Br J Anaesth. 2012;109(6):897–906. https://doi.org/10.1093/bja/aes308. Epub 2012 Sep 6 PMID: 22956642.
Altree TJ, Chung F, Chan MTV, Eckert DJ. Vulnerability to postoperative complications in obstructive sleep apnea: importance of phenotypes. Anesth Analg. 2021;132(5):1328–37. https://doi.org/10.1213/ANE.0000000000005390. PMID: 33857975.
Subramani Y, Singh M, Wong J, Kushida CA, Malhotra A, Chung F. Understanding phenotypes of obstructive sleep apnea: applications in anesthesia, surgery, and perioperative medicine. Anesth Analg. 2017;124(1):179–91. https://doi.org/10.1213/ANE.0000000000001546. PMID: 27861433; PMCID: PMC5429962.
BC, Kharbanda OP, Sardana HK, Balachandran R, Sardana V, Kapoor P, Gupta A, Vasamsetti S,. Craniofacial and upper airway morphology in adult obstructive sleep apnea patients: a systematic review and meta-analysis of cephalometric studies. Sleep Med Rev. 2017;31:79–90. https://doi.org/10.1016/j.smrv.2016.01.007. Epub 2016 Jan 30. PMID: 27039222.
Lowe AA, Santamaria JD, Fleetham JA, Price C. Facial morphology and obstructive sleep apnea. Am J Orthod Dentofacial Orthop. 1986;90(6):484–91. https://doi.org/10.1016/0889-5406(86)90108-3. PMID: 3098087.
Peppard PE, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA. 2000;284:3015–21. https://doi.org/10.1001/jama.284.23.3015.
Strobel RJ, Rosen RC. Obesity and weight loss in obstructive sleep apnea: a critical review. Sleep. 1996;19:104–15.
Isono S. Obesity and obstructive sleep apnoea: mechanisms for increased collapsibility of the passive pharyngeal airway. Respirology. 2012;17(1):32–42. https://doi.org/10.1111/j.1440-1843.2011.02093.x. PMID: 22023094.
Eckert DJ, Owens RL, Kehlmann GB, Wellman A, Rahangdale S, Yim-Yeh S, White DP, Malhotra A. Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold. Clin Sci (Lond). 2011;120(12):505–14. https://doi.org/10.1042/CS20100588. PMID: 21269278; PMCID: PMC3415379.
Vasu TS, Grewal R, Doghramji K. Obstructive sleep apnea syndrome and perioperative complications: a systematic review of the literature. J Clin Sleep Med. 2012;8(2):199–207. https://doi.org/10.5664/jcsm.1784. PMID: 22505868; PMCID: PMC3311420.
Oshita H, Ito N, Senoo M, Funaishi K, Mitama Y, Okusaki K. The STOP-Bang test is useful for predicting the severity of obstructive sleep apnea. JMA J. 2020;3(4):347–52. https://doi.org/10.31662/jmaj.2020-0002. Epub 2020 Oct 2. PMID: 33225107; PMCID: PMC7676986.
Khan MN, Ahmed A. Accuracy of STOP-Bang Questionnaire in predicting difficult mask ventilation: an observational study. Cureus. 2021;13(6):e15955. https://doi.org/10.7759/cureus.15955. PMID: 34336451; PMCID: PMC8314963.
Tan A, Yin JD, Tan LW, van Dam RM, Cheung YY, Lee CH. Using the Berlin Questionnaire to predict obstructive sleep apnea in the general population. J Clin Sleep Med. 2017;13(3):427–32. https://doi.org/10.5664/jcsm.6496. PMID: 27855742; PMCID: PMC5337590.
Gross JB, Bachenberg KL, Benumof JL, Caplan RA, Connis RT, Coté CJ, Nickinovich DG, Prachand V, Ward DS, Weaver EM, Ydens L, Yu S, American Society of Anesthesiologists Task Force on Perioperative Management. Practice guidelines for the perioperative management of patients with obstructive sleep apnea: a report by the American Society of Anesthesiologists Task Force on Perioperative Management of patients with obstructive sleep apnea. Anesthesiology. 2006;104(5):1081–93; quiz 1117–8. https://doi.org/10.1097/00000542-200605000-00026. PMID: 16645462.
Ramachandran SK, Kheterpal S, Consens F, Shanks A, Doherty TM, Morris M, Tremper KK. Derivation and validation of a simple perioperative sleep apnea prediction score. Anesth Analg. 2010;110(4):1007–15. https://doi.org/10.1213/ANE.0b013e3181d489b0. PMID: 20357144.
Chung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, Islam S, Khajehdehi A, Shapiro CM. STOP questionnaire: a tool to screen patients for obstructive sleep apnea. Anesthesiology. 2008;108(5):812–21. https://doi.org/10.1097/ALN.0b013e31816d83e4. PMID: 18431116.
Chung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, Islam S, Khajehdehi A, Shapiro CM. Validation of the Berlin questionnaire and American Society of Anesthesiologists checklist as screening tools for obstructive sleep apnea in surgical patients. Anesthesiology. 2008;108(5):822–30. https://doi.org/10.1097/ALN.0b013e31816d91b5. PMID: 18431117.
Chung F, Memtsoudis SG, Ramachandran SK, Nagappa M, Opperer M, Cozowicz C, Patrawala S, Lam D, Kumar A, Joshi GP, Fleetham J, Ayas N, Collop N, Doufas AG, Eikermann M, Englesakis M, Gali B, Gay P, Hernandez AV, Kaw R, Kezirian EJ, Malhotra A, Mokhlesi B, Parthasarathy S, Stierer T, Wappler F, Hillman DR, Auckley D. Society of Anesthesia and Sleep Medicine guidelines on preoperative screening and assessment of adult patients with obstructive sleep apnea. Anesth Analg. 2016;123(2):452–73. https://doi.org/10.1213/ANE.0000000000001416. PMID: 27442772; PMCID: PMC4956681.
Apfelbaum JL, Hagberg CA, Connis RT, Abdelmalak BB, Agarkar M, Dutton RP, Fiadjoe JE, Greif R, Klock PA, Mercier D, Myatra SN, O’Sullivan EP, Rosenblatt WH, Sorbello M, Tung A. 2022 American Society of Anesthesiologists Practice Guidelines for management of the difficult airway. Anesthesiology. 2022;136(1):31–81. https://doi.org/10.1097/ALN.0000000000004002. PMID: 34762729.
Nagappa M, Wong DT, Cozowicz C, Ramachandran SK, Memtsoudis SG, Chung F. Is obstructive sleep apnea associated with difficult airway? Evidence from a systematic review and meta-analysis of prospective and retrospective cohort studies. PLoS ONE. 2018;13(10):e0204904. https://doi.org/10.1371/journal.pone.0204904. PMID: 30286122; PMCID: PMC6171874.
Chung F, Yegneswaran B, Herrera F, Shenderey A, Shapiro CM. Patients with difficult intubation may need referral to sleep clinics. Anesth Analg. 2008;107(3):915–20. https://doi.org/10.1213/ane.0b013e31817bd36f. PMID: 18713905.
Memtsoudis SG, Cozowicz C, Nagappa M, Wong J, Joshi GP, Wong DT, Doufas AG, Yilmaz M, Stein MH, Krajewski ML, Singh M, Pichler L, Ramachandran SK, Chung F. Society of Anesthesia and Sleep Medicine guideline on intraoperative management of adult patients with obstructive sleep apnea. Anesth Analg. 2018;127(4):967–87. https://doi.org/10.1213/ANE.0000000000003434. PMID: 29944522; PMCID: PMC6135479.
Ahmad I, El-Boghdadly K, Bhagrath R, Hodzovic I, McNarry AF, Mir F, O’Sullivan EP, Patel A, Stacey M, Vaughan D. Difficult Airway Society guidelines for awake tracheal intubation (ATI) in adults. Anaesthesia. 2020;75(4):509–28. https://doi.org/10.1111/anae.14904. Epub 2019 Nov 14. PMID: 31729018; PMCID: PMC7078877.
Maddison KJ, Walsh JH, Shepherd KL, Bharat C, Lawther BK, Platt PR, Eastwood PR, Hillman DR. Comparison of collapsibility of the human upper airway during anesthesia and during sleep. Anesth Analg. 2020;130(4):1008–17. https://doi.org/10.1213/ANE.0000000000004070. PMID: 30896596.
Hafeez KR, Tuteja A, Singh M, Wong DT, Nagappa M, Chung F, Wong J. Postoperative complications with neuromuscular blocking drugs and/or reversal agents in obstructive sleep apnea patients: a systematic review. BMC Anesthesiol. 2018;18(1):91. https://doi.org/10.1186/s12871-018-0549-x. PMID: 30025517; PMCID: PMC6053808.
De Oliveira GS Jr, Fitzgerald PC, Hansen N, Ahmad S, McCarthy RJ. The effect of ketamine on hypoventilation during deep sedation with midazolam and propofol: a randomised, double-blind, placebo-controlled trial. Eur J Anaesthesiol. 2014;31(12):654–62. https://doi.org/10.1097/EJA.0000000000000025. PMID: 24247410.
Xu J, Jin C, Cui X, Jin Z. Comparison of Dexmedetomidine versus Propofol for Sedation after Uvulopalatopharyngoplasty. Med Sci Monit. 2015;22(21):2125–33. https://doi.org/10.12659/MSM.893884. PMID: 26200038; PMCID: PMC4515936.
Gupta K, Nagappa M, Prasad A, Abrahamyan L, Wong J, Weingarten TN, Chung F. Risk factors for opioid-induced respiratory depression in surgical patients: a systematic review and meta-analyses. BMJ Open. 2018;8(12):e024086. https://doi.org/10.1136/bmjopen-2018-024086. PMID: 30552274; PMCID: PMC6303633.
Cozowicz C, Memtsoudis SG. Perioperative management of the patient with obstructive sleep apnea: a narrative review. Anesth Analg. 2021;132(5):1231–43. https://doi.org/10.1213/ANE.0000000000005444. PMID: 33857965.
Baluch A, Mahbubani S, Al-Fadhli F, Kaye AD, Kaye A, Frost EA. Anesthetic care of the patient with obstructive sleep apnea. Middle East J Anaesthesiol. 2009;20:143–52.
Isono S, Tanaka A, Nishino T. Lateral position decreases collapsibility of the passive pharynx in patients with obstructive sleep apnea. Anesthesiology. 2002;97(4):780–5. https://doi.org/10.1097/00000542-200210000-00006. PMID: 12357140.
Liao P, Wong J, Singh M, Wong DT, Islam S, Andrawes M, Shapiro CM, White DP, Chung F. Postoperative oxygen therapy in patients with OSA: a randomized controlled trial. Chest. 2017;151(3):597–611. https://doi.org/10.1016/j.chest.2016.12.005. Epub 2016 Dec 19 PMID: 28007620.
Chung F, Wong J, Mestek ML, Niebel KH, Lichtenthal P. Characterization of respiratory compromise and the potential clinical utility of capnography in the post-anesthesia care unit: a blinded observational trial. J Clin Monit Comput. 2020;34(3):541–51. https://doi.org/10.1007/s10877-019-00333-9. Epub 2019 Jun 7. PMID: 31175500; PMCID: PMC7205778.
Rosenberg J, Wildschiødtz G, Pedersen MH, von Jessen F, Kehlet H. Late postoperative nocturnal episodic hypoxaemia and associated sleep pattern. Br J Anaesth. 1994;72(2):145–50. https://doi.org/10.1093/bja/72.2.145. PMID: 8110563.
Cheng MCF, Steier J. Pre-operative screening for sleep disordered breathing: obstructive sleep apnoea and beyond. Breathe (Sheff). 2022;18(3):220072. https://doi.org/10.1183/20734735.0072-2022. Epub 2022 Oct 11. PMID: 36340822; PMCID: PMC9584551.
Abdelsattar ZM, Hendren S, Wong SL, Campbell DA Jr, Ramachandran SK. The impact of untreated obstructive sleep apnea on cardiopulmonary complications in general and vascular surgery: a cohort study. Sleep. 2015;38(8):1205–10. https://doi.org/10.5665/sleep.4892. PMID: 25761980; PMCID: PMC4507725.
Neligan PJ, Malhotra G, Fraser M, Williams N, Greenblatt EP, Cereda M, Ochroch EA. Continuous positive airway pressure via the Boussignac system immediately after extubation improves lung function in morbidly obese patients with obstructive sleep apnea undergoing laparoscopic bariatric surgery. Anesthesiology. 2009;110(4):878–84. https://doi.org/10.1097/ALN.0b013e31819b5d8c. PMID: 19293693.
Liao P, Luo Q, Elsaid H, Kang W, Shapiro CM, Chung F. Perioperative auto-titrated continuous positive airway pressure treatment in surgical patients with obstructive sleep apnea: a randomized controlled trial. Anesthesiology. 2013;119(4):837–47. https://doi.org/10.1097/ALN.0b013e318297d89a. Erratum. In: Anesthesiology. 2014;120(5):1302. Erratumin: Anesthesiology. 2014;120(5):1302 . PMID: 24195872.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing Interests
The authors declare no competing interests.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Methods
The literature search was conducted from September to October 2022 using Pubmed and Google Scholar database. Search terms included “obstructive sleep apnea”, “perioperative morbidity”, “opioids and OSA”, “intubation, anesthesia and OSA”, “upper airway and OSA”. Only articles published in English were included. We focused on articles published from January 2017 to September 2022 including randomized control trails, cohort studies, and literature reviews. A meta-analysis was not performed.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Sidhu, H., Chediak, A., Kalra, A. et al. Assessing and Managing Surgical Risk in Obstructive Sleep Apnea: A Narrative Review. Curr Pulmonol Rep 13, 10–17 (2024). https://doi.org/10.1007/s13665-023-00333-w
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13665-023-00333-w