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Upper Airway Stimulation for Treatment of Obstructive Sleep Apnea

  • Sleeping and Breathing (J Puchalski, Section Editor)
  • Published:
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Abstract

Purpose of Review

We proposed to describe hypoglossal nerve stimulation therapy of obstructive sleep apnea emphasizing the evidence for benefit and identifying patient selection factors foretelling of favorable outcomes.

Recent Findings

Hypoglossal nerve stimulation has proven to have lasting efficacy in the treatment of multiple aspects of obstructive sleep apnea including event frequency, nocturnal hypoxemia, sleepiness, patient quality of life, sleep architecture, and treatment adherence. Obstructive sleep apnea severity, pattern of pharyngeal collapse, weight, age, and previous surgery are cited predictors of hypoglossal nerve stimulation outcomes. Advances in science have honed the clinical and historical factors predictive of hypoglossal nerve stimulation therapy efficacy.

Summary

Positive airway pressure therapy is the primary therapeutic modality for sleep apnea. However, some subjects given positive airway pressure fail to accept or reliably adhere to treatment. Hypoglossal nerve stimulation therapy can be offered as alternative in such cases. Science has identified clinical features predictive of efficacy.

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References

  1. Young T, Palta M, Dempsey J. The occurrence of sleep-disordered breathing among middle aged adults. N Engl J Med. 1993;328:1230–5.

    Article  CAS  Google Scholar 

  2. Yaggi H, Concato J, Keman W, Lichtman J, Brass L, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353:2034–41.

    Article  CAS  Google Scholar 

  3. Shahar E, WHitney C, Redline S, Samet J. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the results of the sleep heart health study. Am J Respir Crit Care Med. 2001;163(1):19–25.

    Article  CAS  Google Scholar 

  4. Eckert D, White D, Jordan A, Malhorta A, Wellman A. Defining phenotypic causes of obstructive sleep apnea. Am J Respir Crit Care Med. 2013;188:996–1004.

    Article  Google Scholar 

  5. Edwards B, Wellman A, Sands S, Owens R, Malhotra A. Obstructive sleep apnea in older adults os a distinctly different pathological phenotype. Sleep. 2014;37(7):1227–36.

    Article  Google Scholar 

  6. Weaver TE, Grunstein RR. Adherence to Continuous Positive Airway Pressure Therapy The Challenge to Effective Treatment 2008, https://doi.org/10.1513/pats.200708-119MG.

  7. Weaver TE, Faan RN, Sawyer AM. Adherence to Continuous Positive Airway Pressure Treatment for Obstructive Sleep Apnea: Implications for Future Interventions.

  8. Strollo PJ, Soose RJ, Maurer JT, et al. Upper-airway stimulation for obstructive sleep apnea. N Engl J Med. 2014;370(2):139–49. https://doi.org/10.1056/NEJMoa1308659.

    Article  CAS  PubMed  Google Scholar 

  9. Decker M, Haaga J, Arnold J, Atzberger D, Strohol K. Functional electrical stimulation and respiration during sleep. J Appl Physiol. 1993;75(3):1053–61.

    Article  CAS  Google Scholar 

  10. Edmonds L, Daniels B, Stanson A, Sheedy PI, Shepards J. The effects of transcutaneous electrical stimulation during wakefulness and sleep in partients with obstructive sleep apnea. Am Rev Respir Dis. 1992;146(4):1030–6.

    Article  CAS  Google Scholar 

  11. Guilleminault C, Powell N, Bowman B, Stoohs R. The effect of electrical stimulation during sleep on upper airway patency in patients with obstructive sleep apnea. Chest. 1995;107(1):67–73.

    Article  CAS  Google Scholar 

  12. Van de Heyning P, Badr S, Baskin J. Implanted upper airway stimulation device for obstructive sleep apnea. Laryngoscope. 2012;122:1626–33.

    Article  Google Scholar 

  13. Steffen A, Sommer JU, Hofauer B, Maurer JT, Hasselbacher K, Heiser C. Outcome after one year of upper airway stimulation for obstructive sleep apnea in a multicenter German post-market study. Laryngoscope. 2017;128(2):509–15.

    Article  Google Scholar 

  14. Bohorquez D, Mahmoud A, Yu J, Thaler E. Upper airway stimulation therapy and sleep architecture in patients with obstructive sleep apnea. Laryngoscope. 2019.

  15. Sarber K, Chang K, Epperson M. Hypoglossal nerve stimulation in veterans with obstructive sleep apnea. Laryngoscope. 2019.

  16. Woodson B, Strohl K, Soose R. Upper airway stimulation for obstructive sleep apnea: 5-year outcomes. Otolaryngol Head Neck Surg. 2018;159(1):194–202.

    Article  Google Scholar 

  17. Huntley C, Kaffenberger T, Doghramji K, Soose R, Boon M. Upper airway stimulation for treatment of obstructive sleep apnea: an evaluation and comparison of outcomes at two academic centers. J Clin Sleep Med. 2017;13(9):1075–9. https://doi.org/10.5664/jcsm.6726.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Bon M, Huntley C, Steffen A, et al. Upper airway stimulation for obstructive sleep apnea: results from the ADHERE registry. Otolaryngol Head Neck Surg. 2018;159(2):379–85.

    Article  Google Scholar 

  19. Woodson B, Soose R, Gillespie MB, et al. Three-year outcomes of cranial nerve stimulation for obstructive sleep apnea: the STAR trial. Otolaryngol Head Neck Surg. 2016;154:181–8.

    Article  Google Scholar 

  20. Kezirian EJ, Hohenhorst W, De Vries N. Drug-induced sleep endoscopy: the VOTE classification. Eur Arch Oto-Rhino-Laryngology. 2011;268:1233–6. https://doi.org/10.1007/s00405-011-1633-8.

    Article  Google Scholar 

  21. Ong A, Murphey A, Nguyen S. Efficacy of upper airway stimulation on collapse patterns observed during drug-induced sedation endoscopy. Otolaryngol Head Neck Surg. 2016;154(5):970–7.

    Article  Google Scholar 

  22. Evans S, Richman J, Cho D-Y, Withrow K. Increasing preoperative apnea severity improves upper airway stimulation response in OSA treatment. Laryngoscope. 2020;130(2):556–60.

    Article  Google Scholar 

  23. Heiser C, Steffen A, Boon M. Post-approval upper airway stimulation predictors of treatment effectiveness in the ADHERE registry. Eur Respir J. 2019;53(1).

  24. Huntley C, Steffen A, Doghramji K, Hofauer B, Heiser C, Boon M. Upper airway stimulation in patients with obstructive sleep apnea and an elevated body mass index: a multi-institutional review. Laryngoscope. 2018;128(10):2425–8.

    Article  Google Scholar 

  25. Withrow K, Evans S, Harwick J, Kezirian E, Strollo P. Upper airway stimulation response in older adults with moderate to severe obstructive sleep apnea. Otolaryngol - Head Neck Surg (United States). 2019;161(4):714–9. https://doi.org/10.1177/0194599819848709.

    Article  Google Scholar 

  26. Kezirian EJ, Heiser C, Steffen A, Boon M, Hofauer B, Doghramji K, et al. Previous surgery and hypoglossal nerve stimulation for obstructive sleep apnea. Otolaryngol - Head Neck Surg (United States). 2019;161(5):897–903. https://doi.org/10.1177/0194599819856339.

    Article  Google Scholar 

  27. Huntley C, Vasconcellos A, Doghramji K, Hofauer B, Heiser C, Boon M. Upper airway stimulation in patients who have undergone unsuccessful prior palate surgery: an initial evaluation. Otolaryngol - Head Neck Surg (United States). 2018;159(5):938–40. https://doi.org/10.1177/0194599818792191.

    Article  Google Scholar 

  28. Mahmoud A, Thaler E. Upper airway stimulation therapy and prior airway surgery for obstructive sleep apnea. Laryngoscope. 2017;128(6):1486–9.

    Article  Google Scholar 

  29. Parikh V, Thaler E, Kato M. Early feasibility of hypoglossal nerve upper airway stimulator in patients with cardiac implantable electronic devices and continuous positive airway pressure-intolerant severe obstructive sleep apnea. Hear Rythm. 2018;15(8):1165–70.

    Article  Google Scholar 

  30. Safiruddin F, Vanderveken OM, De Vries N, et al. Effect of upper-airway stimulation for obstructive sleep apnoea on airway dimensions. Eur Respir J. 2015;45(1):129–38. https://doi.org/10.1183/09031936.00059414.

    Article  PubMed  Google Scholar 

  31. Mahmoud AF, Thaler ER. Outcomes of hypoglossal nerve upper airway stimulation among patients with isolated retropalatal collapse. Otolaryngol - Head Neck Surg (United States). 2019;160(6):1124–9. https://doi.org/10.1177/0194599819835186.

    Article  Google Scholar 

  32. Sturm J, Modik O, Suurna M. Neurophysiological monitoring of tongue muscle activation during hypoglossal nerve stimulation. Laryngoscope. 2019.

  33. Steffen A, Kilic A, Konig I, Suurna M, Hofauer B, Heiser C. Tongue motion variability with changes of upper airway stimulation electrode configuration and effects on treatment outcomes. Laryngoscope. 2018;128(8):1970–6.

    Article  Google Scholar 

  34. Heiser C, Maurer JT, Steffen A. Functional outcome of tongue motions with selective hypoglossal nerve stimulation in patients with obstructive sleep apnea. Sleep Breath. 2016;20(2):553–60. https://doi.org/10.1007/s11325-015-1237-4.

    Article  CAS  PubMed  Google Scholar 

  35. Kumar A, Vasconcellos A, Boon M, Huntley C. Inclusion of the first cervical nerve does not influence outcomes in upper airway stimulation for treatment of obstructive sleep apnea. Laryngoscope. 2019

  36. Irvine L, Yang Z, Kezirian E, et al. Hyoepiglottic ligamentcollagen and elastin fiber compositionand changes associated with aging. Laryngoscope. 2018;128:1245–8.

    Article  CAS  Google Scholar 

  37. Heiser C, Edenharter G, Bas M, Wirth M, Hofauer B. Palatoglossus coupling in selective upper airway stimulation. Laryngoscope. 2017;127(10):378–83.

    Article  Google Scholar 

  38. Liu SYC, Wayne Riley R, Pogrel A, Guilleminault C. Sleep surgery in the era of precision medicine. Atlas Oral Maxillofac Surg Clin North Am. 2019;27(1):1–5.

    Article  CAS  Google Scholar 

  39. Liu SYC, Hutz MJ, Poomkonsarn S, Chang CP, Awad M, Capasso R. Palatopharyngoplasty resolves concentric collapse in patients ineligible for upper airway stimulation. Laryngoscope. 2020.

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Authors and Affiliations

Authors

Contributions

All authors met the four criteria for authorship established by the International Committee of Medical Journal Editors: Carlos Torre, Elie Alam, Alejandro Chediak, and Alexandre Abreu were responsible for the conception, design, and drafting the work, revising the work, and reviewing the manuscript. All authors provided final approval of the version to be published and agreed to be accountable for all aspects of the work in ensuring including the accuracy and/or integrity of the work.

Corresponding author

Correspondence to Carlos Torre.

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Torre, C., Alam, E., Abreu, A. et al. Upper Airway Stimulation for Treatment of Obstructive Sleep Apnea. Curr Pulmonol Rep 10, 40–45 (2021). https://doi.org/10.1007/s13665-020-00264-w

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