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Comparison of cytologic findings between specimens with and without high-risk HPV infection in those with ASC-US judgement

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Abstract

The objective of the study was to realize whether specific signatures for high-risk human papilloma virus (HPV) infection exist in the cytologic specimens with ASC-US judgement or not. The materials are 132 cytologic specimens with the diagnosis of ASC-US, including 56 cases with positive and 76 cases with negative HPV infection. Cytological findings are compared between two groups. Immature squamous metaplastic cells with nuclear atypia, SFT/IMT dyskaryotic cells, atypical parakeratosis, smudgy nuclei and multinucleated cells are the signature of high-risk HPV infection, whereas in the HPV(−) group immature metaplastic cells without atypia, moderately mature metaplastic cells without nuclear atypia and atrophic background are more popular. Instead, there are no differences on SFT/IMT background, microorganism infection and koilocytosis with or without nuclear atypia in both groups. The specific findings to confirm high-risk HPV infection are realized and the present results will contribute to decrease an unnecessary ASC-US judgement.

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Authors and Affiliations

  1. Cytology Center, The Kanagawa Health Service Association, 58 Nihon-Ohdori Naka-ku, Yokohama-shi, Kanagawa, 231-0021, Japan

    Hiroyuki Kuramoto, Midori Banno, Naoko Sugimoto, Takashi Sugahara, Chizuyo Kato, Masuko Hori & Akihiro Kimura

  2. Department of Cancer Detection for Females, The Kanagawa Health Service Association, 58 Nihon-Ohdori Naka-ku, Yokohama-shi, Kanagawa, 231-0021, Japan

    Hiroyuki Kuramoto & Akihiro Kimura

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  1. Hiroyuki Kuramoto
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  2. Midori Banno
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  3. Naoko Sugimoto
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  4. Takashi Sugahara
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  5. Chizuyo Kato
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  6. Masuko Hori
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  7. Akihiro Kimura
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Correspondence to Hiroyuki Kuramoto.

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Kuramoto, H., Banno, M., Sugimoto, N. et al. Comparison of cytologic findings between specimens with and without high-risk HPV infection in those with ASC-US judgement. Human Cell 33, 397–404 (2020). https://doi.org/10.1007/s13577-019-00307-8

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  • DOI: https://doi.org/10.1007/s13577-019-00307-8

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