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Effect of morroniside on glomerular mesangial cells through AGE–RAGE pathway

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Abstract

Diabetes mellitus is an endocrine and metabolic disease characterized by high blood glucose. Diabetic nephropathy (DN) is one of the most typical diabetic complications. Cornus officinalis is a type of traditional Chinese medicine that replenishes the liver and kidney. Morroniside is one of the main characteristic components of C. officinalis. In this study, an in vitro model for simulating DN damage was established by stimulating rat glomerular mesangial cells by the advanced glycation end products. The protective mechanism and effect of morroniside in regulating receptor for advanced glycation end products signaling pathway in DN was investigated to provide experimental evidence for the prevention and treatment of DN.

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Acknowledgments

This work is supported by the National Natural Science Fund of China (No. 81073111), and Project Supported by the Discipline Construction Project of Jiangsu Colleges and Universities (No. Nzyzyxjg-1006).

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    Authors and Affiliations

    1. Department of Pharmacology of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China

      Gaohong Lv, Xing Lv, Yuhan Tao & Huiqin Xu

    2. Jiang Su Key Laboratory for Efficacy and Safety Evaluation of Chinese Medicine, Nanjing, 210023, Jiangsu, China

      Huiqin Xu

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    1. Gaohong Lv
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    2. Xing Lv
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    Correspondence to Huiqin Xu.

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    G. Lv and X. Lv contributed equally.

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    Lv, G., Lv, X., Tao, Y. et al. Effect of morroniside on glomerular mesangial cells through AGE–RAGE pathway. Human Cell 29, 148–154 (2016). https://doi.org/10.1007/s13577-015-0128-0

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    • DOI: https://doi.org/10.1007/s13577-015-0128-0

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