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Transcatheter aortic valve replacement in patients with prior chest irradiation and severe aortic stenosis

  • Original Research
  • Published:
Journal of Radiation Oncology

Abstract

Background/methods

Transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis, prior chest irradiation, and porcelain aorta may be preferable to traditional surgery but has not been previously evaluated.

Results

Ten patients (mean age 60 years, 50 % male) with severe aortic stenosis (valve area 0.68 ± 0.15 cm2), prior chest irradiation for malignancy, and porcelain aorta underwent TAVR (transfemoral in 90 %). The procedure was successful in all patients with average ICU stay of 1.2 ± 0.6 days, overall hospital stay of 4.8 ± 1.8 days, and 30-day mortality of 0 %.

Conclusions

TAVR is a safe and effective alternative treatment in aortic stenosis patients with prior chest irradiation and porcelain aorta and may very well become the preferred approach.

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Compliance with ethical standards

Funding

This study was not funded.

Author information

Authors and Affiliations

  1. Hygeia Hospital, 9 Erythrou Stavrou, Amarousion, 15123, Athens, Attiki, Greece

    Michael P. Chrissoheris, Adamantios Tsangaris, Antonios Chalapas & Konstantinos Spargias

Authors
  1. Michael P. Chrissoheris
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  2. Adamantios Tsangaris
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  3. Antonios Chalapas
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  4. Konstantinos Spargias
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Corresponding author

Correspondence to Michael P. Chrissoheris.

Ethics declarations

Authors M. Chrissoheris, A. Chalapas, and K. Spargias have received educational and travel grants from Edwards Lifesciences, Medtronic, St. Jude Medical and Abbott Vascular. Author Adamantios Tsangaris has nothing to disclose.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Please note that patients were not exposed to experimental treatments but to procedures done for appropriate indications and that have received CE mark in Europe and FDA approval in the USA.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

This manuscript is submitted for publication to the Journal of Radiation Oncology as an original article. Neither the entire paper nor any of its contents is currently being submitted or has been accepted by any other journal.

All authors have read and approved the manuscript.

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Chrissoheris, M.P., Tsangaris, A., Chalapas, A. et al. Transcatheter aortic valve replacement in patients with prior chest irradiation and severe aortic stenosis. J Radiat Oncol 5, 257–263 (2016). https://doi.org/10.1007/s13566-016-0251-x

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  • DOI: https://doi.org/10.1007/s13566-016-0251-x

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