Skip to main content
Log in

Acute toxic exposures in Egypt population: analysis of a five-year registry from 2015 to 2019

  • Original Article
  • Published:
Toxicology and Environmental Health Sciences Aims and scope Submit manuscript

A Publisher Correction to this article was published on 15 July 2022

This article has been updated

Abstract

Introduction

Poisoning is regarded as a significant threat to public health all over the world. Determining the poisoning trend and its causative agents is essential for developing effective poisoning prevention and targeted intervention programs.

Methods

A hospital-based retrospective observational study was conducted using electronic databases and medical records of acutely poisoned patients presented to the Poison Control Center of Ain Shams University Hospitals (PCC-ASUH) for the period from 2015 to 2019. Demographics and types of the poisoning exposures of all included patients were extracted, and descriptive analysis was performed to investigate the outcomes.

Results

From 2015 to 2019, we collected data from 115402 patients. The current findings revealed that the majority of poisoned patients were between the ages of 15 and 25 across all studied years. The number of male and female patients was not significantly different. The oral route was the most common poisoning route. Suicidal and accidental modes of poisoning were the most common poisoning modes. Greater Cairo governorates had more patients than other Egyptian regions. Drug exposure was significantly more prevalent than non-drug poisoning. In all studied years, the mild degree of poisoning was the most pervasive. The majority of presented cases required hospitalization and poisoning management in less than 6 hours. Enhanced elimination was the most frequently used toxicological management measure used across all study years, followed by antidotes.

Conclusion

The current study investigated the main intoxicated patients' demographics and characteristics of poisoning exposures in Egyptian people. We highlighted the impact of intentional, or accidental exposure, in addition to demonstrating the utility of specific poison centers in the management of various cases and the different strategies that can be implemented to decrease fatality and improve health care.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Data availability

The datasets generated and analyzed during the current study are available from the corresponding author upon request.

Change history

References

  1. Boyle JS, Bechtel LK, Holstege CP (2009) Management of the critically poisoned patient. Scand J Trauma Resusc Emerg Med. https://doi.org/10.1186/1757-7241-17-29

    Article  PubMed  PubMed Central  Google Scholar 

  2. El Gendy MA, Alfadaly N, Mohamed IN (2018) Retrospective and statistical study of pattern of acute poisoning among cases presented to emergency department of Kafr El-sheikh Governorate hospitals. Egypt J Hosp Med 73(3):6272–6282

    Article  Google Scholar 

  3. Afshari R, Majdzadeh R, Balai-Mood M (2004) Pattern of acute poisoning in Mashhad. Iran J Toxicol Clin 42:965–75

    CAS  Google Scholar 

  4. Bari MS, Chakraborty SR, Alam MMJ, Qayyum JA, Hassan N, Chowdhury FR (2014) Four-year study on acute poisoning cases admitted to a tertiary hospital in Bangladesh: Emerging Trend of Poisoning in Commuters, APJMT

  5. Kumar A, Verma A, Jaiswal K, Kumar S, Prasad R (2012) Emergence of entirely new poisoning in rural India; An upcoming health hazard to the community health.”. Indian J Commun Heal 24:248–51

    Google Scholar 

  6. Dulger AC, Karadas S, Gonullu H et al (2014) Analyses of etiologic and sociodemographic properties of the intoxicated cases in van city and its environs. J Clin. Toxicol 2:119

    Google Scholar 

  7. Lee H-L, Lin H-J, Yeh T-Y (2004) The epidemiology and prognostic factors of poisoning. Epidemiology 15:179–80

    Article  Google Scholar 

  8. Ostad-Ali-Askari K, Shayannejad M, Ghorbanizadeh-Kharazi H (2017) Artificial neural network for modeling nitrate pollution of groundwater in marginal area of Zayandeh-rood River, Isfahan, Iran. KSCE J Civ Eng 21:134–140

    Article  Google Scholar 

  9. Asawari R, Atmaram P, Bhagwan K, Priti D, Kavya S, Jabeen GA (2017) Toxicological pattern of poisoning in Urban Hospitals of Western India. J Young Pharm 9(3):315–320

    Article  Google Scholar 

  10. Chelkeba L, Mulatu A, Feyissa D, Bekele F, Tesfaye BT (2018) Patterns and epidemiology of acute poisoning in Ethiopia: systematic review of observational studies. Arch Public Health 76:34

    Article  Google Scholar 

  11. Tefera GM, Teferi LG (2020) Prevalence, predictors and treatment outcome of acute poisoning in Western Ethiopia. Open Access Emerg Med 12:365–375

    Article  Google Scholar 

  12. Bundotich JK, Gichuhi MM (2015) Acute poisoning in the Rift Valley Provincial General Hospital, Nakuru, Kenya: January to June 2012. S Afr Fam Pr 3:214–218

    Article  Google Scholar 

  13. Zhang Y, Yu B, Wang N, Li T (2018) Acute poisoning in Shenyang, China: a retrospective and descriptive study from 2012 to 2016. BMJ Open 8(8):e021881

    Article  Google Scholar 

  14. Saoraya J, Inboriboon PC (2013) Acute poisoning surveillance in Thailand: the current state of affairs and a vision for the future. ISRN Emerg Med 2013:1–9

    Article  Google Scholar 

  15. Original A (1980) Trends of drug-related poisoning cases attended to at a poison control center, pp 1–13

  16. B. Tangiisuran et al. (2018) Evaluation of types of poisoning exposure calls managed by the Malaysia National Poison Centre (2006–2015): a retrospective review,” no. August 2016, pp 1–7

  17. Adinew GM, Asrie AB, Birru EM (2017) Pattern of acute organophosphorus poisoning at University of Gondar Teaching Hospital, Northwest Ethiopia. BMC Res Notes [Internet]. Department of Pharmacology, School of Pharmacy, College of Medicine and Health Science, University of Gondar, Gondar, Ethi,” BioMed Cent. Ltd., 1(10)

  18. Teklemariam E, Tesema S, Jemal A (2016) Pattern of acute poisoning in Jimma University specialized hospital, south West Ethiopia”. World J Emerg Med China 7(4):290–293

    Article  Google Scholar 

  19. Gummin DD, Mowry JB, Spyker DA, Brooks DE, Beuhler MC, Rivers LJ, Hashem HA, Ryan ML (2019) 2018 Annual report of the American Association of Poison Control Centres’ National Poison Data System (NPDS): 36th annual report. Clin Toxicol 57(12):1220–1413

    Article  CAS  Google Scholar 

  20. Ornillo NHC (2020) Fundaments of toxicology approach to the poisoned patient. Adv Chronic Kidney Dis 27(1):5–10

    Article  Google Scholar 

  21. Bacha T, Tilahun B (2015) A cross-sectional study of children with acute poisoning: a three-year retrospective analysis. World J Emerg Med 6(4):265

    Article  Google Scholar 

  22. Chala TS, Gebramariam H, Hussen M (2015) Two-year epidemiologic pattern of acute pharmaceutical and chemical poisoning cases admitted to Adama hospital medical college, Adama, Ethiopia. Asia Pacific J med Toxicol 4(3):106–111

    Google Scholar 

  23. Maheswari E, Abraham L, Chacko CS, Saraswathy GR (2016) Assessment of pattern, severity and outcome of poisoning in emergency care unit. J Appl Pharm Sci 6(12):178–183

    Article  Google Scholar 

  24. Desalew M, Aklilu A, Amanuel A, Addisu M, Ethiopia T (2011) Pattern of acute adult poisoning at TikurAnbessa specialized teaching hospital, a retrospective study, Ethiopia. Hum Exp Toxicol 30(7):523–527

    Article  Google Scholar 

  25. Marano M et al (2021) Acute toxic exposures in children: analysis of a three year registry managed by a pediatric poison control center in Italy. Ital J Pediatr. https://doi.org/10.1186/s13052-021-01071-y

    Article  PubMed  PubMed Central  Google Scholar 

  26. “Suicide.” [Online]. https://www.who.int/health-topics/suicide#tab=tab_1. [Accessed: 27-Oct-2021]

  27. Mehrpour O, Akbari A, Jahani F (2018) Epidemiological and clinical profiles of acute poisoning in patients admitted to the intensive care unit in eastern Iran (2010 to 2017). BMC Emerg Med. https://doi.org/10.1186/s12873-018-0181-6

    Article  PubMed  PubMed Central  Google Scholar 

  28. Kamau MS, Kipbichii CA, Ruiru MH (2014) Intensive care management of poisoning in a resource-limited health care setting in Western Kenya. Int J Humanit Soc Sci 189:189–94

    Google Scholar 

  29. Bilal M, Khan Y, Ali S (2014) The pattern of organophosphorus poisoning and it’s short term outcomes in various socioeconomic groups. KJMS 7(1):11

    Article  Google Scholar 

  30. George EJ, Jeyaraj K, Manjaly JJ (2015) Clinical profile and outcome of organophosphate poisoning cases in a tertiary care hospital in Central Kerala. Int J Recent Trends Sci Technol 14(2):338–343

    Google Scholar 

  31. Farzaneh E, Ghobadi H, Akbarifard M, Nakhaee S, Amirabadizadeh A, Akhavanakbari G et al (2018) Prognostic factors in acute aluminium phosphide poisoning: a risk-prediction nomogram approach. Basic Clin Pharmacol Toxicol 123(3):347–355

    Article  CAS  Google Scholar 

  32. Lam SM, Lau AC, Yan WW (2010) Over 8 years experience on severe acute poisoning requiring intensive care in Hong Kong, China. Hum Exp Toxicol. 29(9):757–65

    Article  Google Scholar 

  33. Encke J, Schwake L, Wollenschläger I, Stremmel W (2009) Adverse drug reactions and deliberate self-poisoning as cause of admission to the intensive care unit: a 1-year prospective observational cohort study. Intensive Care Med. 35(2):266–74

    Article  Google Scholar 

  34. Persson HE, Sjoberg GK, Haines JA (1998) Poisoning severity score. Grading of acute poisoning. J Toxicol Clin Toxicol 36(3):205–213

    Article  CAS  Google Scholar 

  35. Junk SH, Park DY, Park JS (2005) Significance of the poisoning severity score as a prognostic factor in poisoning. J Korean Soc Emerg Med 16(6):660–666

    Google Scholar 

  36. (2013) “World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects,” JAMA, 310 (20), 2191–2194

Download references

Funding

There has been no significant financial support for this work that could have influenced its outcome.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dalia Zaafar.

Ethics declarations

Conflict of interest

Walaa G. Abdelhamid, Maha M. Wahdan, Dalia Zaafar declare that we have no conflict of interest.

Ethical approval

This study is a hospital-based retrospective observational study performed using electronic databases and medical records of acutely poisoned patients presented to the Poison Control Center of Ain Shams University Hospitals (PCC-ASUH) for the period from 2015 to 2019, and it was approved by the Ethical Committee of PCC-ASUH.

Additional information

The original online version of this article was revised: corrections in Table 5 were not carried out.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Abdelhamid, W.G., Wahdan, M.M. & Zaafar, D. Acute toxic exposures in Egypt population: analysis of a five-year registry from 2015 to 2019. Toxicol. Environ. Health Sci. 14, 235–244 (2022). https://doi.org/10.1007/s13530-022-00134-9

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13530-022-00134-9

Keywords

Navigation