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The correlation between serum 1, 5-anhydroglucitol and β-cell function in Chinese adults with different glucose metabolism statuses

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Objective

Serum 1, 5-AG is a glycaemic marker reflecting control and fluctuations of short-term glucose. To reveal the relationship between 1, 5-AG with β-cell function, we investigated a certain number of Chinese adults with different glucose metabolisms.

Methods

In clinical cross-sectional study, 2184 subjects with no prior diabetes history are included and underwent an OGTT. HOMA-IR and HOMA-β were calculated. Correlations between 1, 5-AG and HOMA-IR or HOMA-β were observed, correcting for interference factors, and independent factors for HOMA-β and HOMA-IR were analysed. Subjects were divided into three groups according to OGTT results, and 1, 5-AG levels differed significantly between them.

Results

A significant positive correlation existed between 1, 5-AG and HOMA-β only in the diabetes mellitus group (r = 0.265, p < 0.001). Above phenomenon remained after adjusting for indicators, however, disappeared after considering serum uric acid. Both 1, 5-AG and HbA1c were independent factors for HOMA-β (1, 5-AG: β = 0.772, p = 0.023; HbA1c: β = -7.52, p = 0.003). Conclusion: 1, 5-AG remained a factor for HOMA-β only for those with NUA. 1, 5-AG reflects different glucose metabolism statuses and is an auxiliary observation reflecting the secretory function of β cells in NUA patients.

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Data availability

All the data supporting the results are shown in the paper and can be applicable from the corresponding author.

Abbreviations

1, 5-AG:

Serum 1, 5-anhydroglucitol

OGTT:

Oral glucose tolerance test

HOMA-IR:

Homeostasis model assessments for insulin resistance

HOMA-β:

Homeostasis model assessments for β cells

NUA:

Normal serum uric

T2DM:

Type 2 diabetes mellitus

OGIRT:

Oral glucose insulin release test

HbA1c:

Glycosylated hemoglobin

GA:

Glycated albumin

FPG:

Fasting blood glucose

2hPG:

2-Hour postprandial plasma glucose

TC:

Total cholesterol

TG:

Triglycerides

HDL-c:

High-density lipoprotein cholesterol

LDL-c:

Low-density lipoprotein cholesterol

BUN:

Blood urea nitrogen

SCr:

Serum creatinine

SUA:

Serum uric acid

eGFR:

Estimated glomerular filtration rate

NGT:

Normal glucose tolerance

IGR:

Impaired glucose regulation

HUA:

High uric acid

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Acknowledgements

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Author notes

  1. Yuexing Yuan and Yuanyuan Tan contributed equally to this work.

Authors and Affiliations

  1. Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing, 210009, China

    Yuexing Yuan, Yuanyuan Tan, Yao Wang, Shanhu Qiu, Jiao Yang & Cheng Chen

  2. Jiaxing Maternity and Child Health Care Hospital, Jiaxing, 314000, China

    Yuanyuan Tan

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  1. Yuexing Yuan
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  6. Cheng Chen
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Corresponding author

Correspondence to Yao Wang.

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Ethical approval

This study was approved in 2017 by the Clinical Ethics Committee of Zhongda Hospital, an affiliate of Southeast University (No.2017ZDSYLL006-P01), and all subjects signed informed consent forms before registration. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. This study was approved by the Clinical Ethics Committee of our hospital and all subjects signed informed consent forms before registration.

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Yuan, Y., Tan, Y., Wang, Y. et al. The correlation between serum 1, 5-anhydroglucitol and β-cell function in Chinese adults with different glucose metabolism statuses. Int J Diabetes Dev Ctries (2023). https://doi.org/10.1007/s13410-023-01295-0

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