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Serum Angiopoietin-2 levels as a marker in type 2 diabetes mellitus complications

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Abstract

Angiopoietin-2 (Ang-2) has been reported to be involved in the development of type 2 diabetes (T2D) and accelerates micro and macro vascular complication. The current study aimed to investigate serum Ang-2 levels in Saudi patients with type 2 diabetes and its complications. In this observational cross-sectional study, serum was collected from 329 T2D subjects aged 34–79 years. All subjects were evaluated for fasting blood glucose (FBG), HbA1c, lipid profile, and kidney profile. Serum concentration of Ang-2 was assayed by ELISA-based method. Mean serum Ang-2 level was significantly higher in female T2D subjects (2881 ± 1550 pg/ml) compared with male T2D subjects (2450 ± 1477 pg/ml). The mean serum Ang-2 levels in female T2D subjects significantly increased with increase in their age and BMI, while mean serum Ang-2 levels did not significantly increase among the male with their age and BMI. A significantly higher level of Ang-2 was found in patients with diabetic complications like neuropathy (3293 ± 1728 pg/ml), retinopathy (2986 ± 1645 pg/ml), and vascular complications (3152 ± 1571 pg/ml). The study has established comprehensive Ang-2 levels in various subsets of adults with diabetes. While interpreting Ang-2 levels, the differences in age and sex need to be taken into account. Diabetic patients with higher Ang-2 levels should be monitored closely and level of serum Ang-2 should be served as a marker to identify patients at high risk of diabetic complications.

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Acknowledgements

The authors would like to acknowledge the members of the research unit, at University Diabetes Center, for patient recruitment.

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Authors and Affiliations

  1. Strategic Center for Diabetes Research, College of Medicine, King Saud University, P.O. Box 245, Riyadh, 11411, Kingdom of Saudi Arabia

    Khalid Siddiqui, Salini Scaria Joy & Shaik Sarfaraz Nawaz

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  1. Khalid Siddiqui
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  2. Salini Scaria Joy
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  3. Shaik Sarfaraz Nawaz
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Contributions

KS conceived and designed the study. KS, SSJ, and SSN conducted the research, provided the research materials, and collected and organized the data. SSN analyzed and interpreted the data. KS wrote the initial and final draft of the article. All of the authors have critically reviewed and approved the final draft and are responsible for the content and similarity index of the manuscript.

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Correspondence to Khalid Siddiqui.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the College of Medicine, King Saud University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Siddiqui, K., Joy, S.S. & Nawaz, S.S. Serum Angiopoietin-2 levels as a marker in type 2 diabetes mellitus complications. Int J Diabetes Dev Ctries 39, 387–393 (2019). https://doi.org/10.1007/s13410-018-0679-1

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  • DOI: https://doi.org/10.1007/s13410-018-0679-1

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