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The link between interleukin-6, anti-cyclic citrullinated peptide and highly sensitive C-reactive protein in type 2 diabetes: age-effect study

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Abstract

Anti-cyclic citrullinated peptide (ACCP) autoantibodies are likely to be involved in the development of rheumatoid arthritis in at least 70 % of the patients. These autoantibodies are associated with type 1 diabetes and may predict the development of rheumatoid arthritis in later life. This study aimed to examine the association between interleukin-6 (IL-6), a proinflammatory cytokine, highly sensitive C-reactive protein (hsCRP), and ACCP autoantibodies in type 2 diabetes (T2D) patients without past or current history of arthropathy taking in consideration the age-effect factor. A total number of 70 T2D patients and 60 healthy subjects were recruited from the center of diabetes in Erbil, Iraq. The patients were grouped into two: group I (age 35–45 years): group IA, healthy subjects and group IB, diabetic patients; group II (age ≥60 years): group IIA, healthy subjects and group IIB, diabetic patients. Fasting serum glucose, HbA1c%, lipid profile, IL-6, hsCRP, and ACCP autoantibodies were determined. Significant alterations in lipid profile were observed in group IIB compared with group IB. Patients of group IIB have significant high serum IL-6 (458.3 ± 43.04 pg/ml), hsCRP (5.576 ± 0.643 mg/L), and ACCP autoantibodies (74.31 ± 8 U/ml) than corresponding group IB: IL-6 (381.4 ± 22.6 pg/ml), hsCRP (4.92 ± 0.343 mg/L), and ACCP (49.43 ± 7.09 U/ml). Significant positive correlation (r = 0.445) between serum IL-6 and ACCP autoantibodies was observed only in group IB. It concludes that proinflammatory markers and autoantibodies that related to arthritis are increased in old diabetic patients compared with younger age, and IL-6 correlated with ACCP autoantibodies in younger patients which indicated age effect.

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References

  1. Van Venrooij WJ, Van Beers JJBC, Pruijn GJM. Anti-CCP antibody, a marker for the early detection of rheumatoid arthritis. Ann N Y Acad Sci. 2008;1143:268–85.

    Article  PubMed  Google Scholar 

  2. van Venrooij WJ, Hazes JM, Visser H. Anticitrullinated protein/peptide antibody and its role in the diagnosis and prognosis of early rheumatoid arthritis. Neth J Med. 2002;60:383–8.

    PubMed  Google Scholar 

  3. Nielen MM, van der Horst AR, van Schaardenburg D, van der Horst-Bruinsma IE, van de Stadt RJ, Aarden L, et al. Antibodies to citrullinated human fibrinogen (ACF) have diagnostic and prognostic value in early arthritis. Ann Rheum Dis. 2005;64:1199–204.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  4. Lindqvist E, Eberhardt K, Bendtzen K, Heinegård D, Saxne T. Prognostic laboratory markers of joint damage in rheumatoid arthritis. Ann Rheum Dis. 2005;64:196–201.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  5. Jorgensen KT, Wiik A, Pedersen M, Hedegaard CJ, Vestergaard BF, Gislefoss RE, et al. Cytokines, autoantibodies and viral antibodies in premorbid and postdiagnostic sera from patients with rheumatoid arthritis: case-control study nested in a cohort of Norwegian blood donors. Ann Rheum Dis. 2008;67:860–6.

    Article  PubMed  CAS  Google Scholar 

  6. Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 2004;50:380–6.

    Article  PubMed  Google Scholar 

  7. Rantapaa-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48:2741–9.

    Article  PubMed  Google Scholar 

  8. Lopez-Longo FJ, Oliver-Minarro D, de la Torre I, Gonzalez-Diaz DR, Sanchez-Ramon S, Rodriguez-Mahou M, et al. Association between anti-cyclic citrullinated peptide antibodies and ischemic heart disease in patients with rheumatoid arthritis. Arthritis Rheum. 2009;61:419–24.

    Article  PubMed  CAS  Google Scholar 

  9. Munakata Y, Kodera T, Saito T, Sasaki T. Rheumatoid arthritis, type 1 diabetes, and Graves’ disease after acute parvovirus B19 infection. Lancet. 2005;366(9487):780.

    Article  PubMed  Google Scholar 

  10. Somers EC, Thomas SL, Smeeth L, Hall AJ. Autoimmune diseases co-occurring within individuals and within families: a systematic review. Epidemiology. 2006;17(2):202–17.

    Article  PubMed  Google Scholar 

  11. Liao KP, Gunnarsson M, Källberg H, Ding B, Plenge RM, Padyukov L, et al. A specific association exists between type 1 diabetes and anti-CCP positive rheumatoid arthritis. Arthritis Rheum. 2009;60(3):653–60.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  12. Spranger J, Kroke A, Möhlig M, Hoffmann K, Bergmann MM, Ristow M, et al. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes. 2003;52:812–7.

    Article  PubMed  CAS  Google Scholar 

  13. Tuttolomondo A, La Placa S, Di Raimondo D, Bellia C, Caruso A, Lo Sasso B, et al. Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity. Cardiovasc Diabetol. 2010;9:50.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Lebovitz HE. Insulin resistance—a common link between type 2 diabetes and cardiovascular disease. Diabetes Obes Metab. 2006;8:237–49.

    Article  PubMed  CAS  Google Scholar 

  15. Kowalska I. Role of adipose tissue in the development of vascular complications in type 2 diabetes mellitus. Diabetes Res Clin Pract. 2007;78:14–22.

    Article  Google Scholar 

  16. Flicker L, McCaul KA, Hankey GJ, Jamrozik K, Brown WJ, Byles JE, et al. Body mass index and survival in men and women aged 70 to 75. J Am Geriatr Soc. 2010;58:234–41.

    Article  PubMed  Google Scholar 

  17. Auyeung TW, Lee JS, Leung J, Kwok T, Leung PC, Woo J. Survival in older men may benefit from being slightly overweight and centrally obese—a 5-year follow-up study in 4,000 older adults using DXA. J Gerontol A Biol Sci Med Sci. 2010;65:99–104.

    Article  PubMed  Google Scholar 

  18. Shimizu T, Miura S, Takeuchi K, Tashiro T, Saku K. Effects of gender and aging in patients who undergo coronary artery bypass grafting: from the FU-Registry. Cardiol J. 2012;19(6):618–24.

    Article  PubMed  Google Scholar 

  19. Yin YW, Sun QQ, Zhang BB, Hu AM, Liu HL, Wang Q, et al. Association between the Interleukin-6 Gene -572 C/G Polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis of 11,681 subjects. Ann Hum Genet. 2013;77(2):106–14.

  20. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 2001;286(3):327–34.

    Article  PubMed  CAS  Google Scholar 

  21. Krakoff J, Funahashi T, Stehouwer CD, Schalkwijk CG, Tanaka S, Matsuzawa Y, et al. Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian. Diabetes Care. 2003;26(6):1745–51.

    Article  PubMed  CAS  Google Scholar 

  22. Hu FB, Meigs JB, Li TY, Rifai N, Manson JE. Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes. 2004;53(3):693–700.

    Article  PubMed  CAS  Google Scholar 

  23. Gottenberg JE, Dayer JM, Lukas C, Ducot B, Chiocchia G, Cantagrel A, et al. Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort. Ann Rheum Dis. 2012;71(7):1243–8.

    Article  PubMed  CAS  Google Scholar 

  24. Fujita T, Hemmi S, Kajiwara M, Yabuki M, Fuke Y, Satomura A, et al. Complement-mediated chronic inflammation is associated with diabetic microvascular complication. Diabetes Metab Res Rev. 2013;29(3):220–6.

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Authors and Affiliations

  1. Presidency Hawler University, Erbil, Iraq

    Zhian Mahmood Ibrahim Dezayee

  2. Department of Pharmacology, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, Iraq

    Marwan Salih Mohamad Al-Nimer

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  1. Zhian Mahmood Ibrahim Dezayee
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  2. Marwan Salih Mohamad Al-Nimer
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Correspondence to Marwan Salih Mohamad Al-Nimer.

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Dezayee, Z.M.I., Al-Nimer, M.S.M. The link between interleukin-6, anti-cyclic citrullinated peptide and highly sensitive C-reactive protein in type 2 diabetes: age-effect study. Int J Diabetes Dev Ctries 35 (Suppl 3), 507–511 (2015). https://doi.org/10.1007/s13410-014-0286-8

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  • DOI: https://doi.org/10.1007/s13410-014-0286-8

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