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Biogenic facile green synthesis of actinobacterium exopolysaccharide-fabricated zinc oxide nanoparticles for the diverse biomedical applications

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Abstract

In this investigation, an eco-friendly co-precipitation green routed approach was performed to synthesize zinc oxide (ZnO-NPs) nanoparticles using the exopolysaccharide of an actinobacterial strain. The formation of ZnO-NPs was initially confirmed by peaks of surface plasmon resonance using UV–Vis spectrophotometer. The synthesized nanoparticles were characterized extensively using energy-dispersive X-ray (EDX), scanning electron microscopy (SEM), X-ray diffractometer (XRD), atomic force microscopy (AFM), particle size analyzer (PSA), thermogravimetric analysis (TGA), differential thermal analysis (DTA), and Fourier transform infrared (FTIR) spectroscopy. The produced crystalline nanoparticles were ranged from 18.0 to 40.0 nm. The formed zinc oxide nanoparticles have revealed strong antioxidant potential and also proved their effectiveness against inflammation. ZnO-NPs also exhibited outstanding bactericidal action against clinical pathogenic bacterial strains. Furthermore, the cytotoxicity of nanoparticles was assessed on breast and cervical carcinoma cells. The morphological changes caused in the cancer cells were observed through different fluorescent studies. This synthesis specifies on greener production of ZnO-NPs, and the attained results suggest that it could be applicable for vital therapeutic uses.

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Acknowledgements

The author, Srinath Rajeswaran was thankful to Neyveli Lignite Corporation India Limited (NLCIL)—Centre of Applied Research and Development (CARD), for providing the financial support through their project fellowship.

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Authors and Affiliations

  1. Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, 641021, Tamil Nadu, India

    Srinath Rajeswaran

  2. Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, 608502, Tamil Nadu, India

    Bharathidasan Veeraiyan

  3. Department of Biotechnology, Sethu Institute of Technology, Virudhunagar, 626115, Tamil Nadu, India

    Vishnuprasad Saravanan

  4. Department of Marine Biology, Sethupathy Government Arts College, Ramanathapuram, 623502, Tamil Nadu, India

    Elangovan Manickam

  5. Centre for Ocean Research (DST-FIST Sponsored Centre), MoES—Earth Science and Technology Cell (Marine Biotechnological Studies), Sathyabama Research Park, Sathyabama Institute of Science and Technology, Chennai, 600119, Tamil Nadu, India

    Jeyapragash Danaraj

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  1. Srinath Rajeswaran
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  2. Bharathidasan Veeraiyan
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  3. Vishnuprasad Saravanan
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Contributions

S.R designed the conceptualized research, carried out the experiments, drafted, edited, and reviewed the manuscript. B.V, V.S, E.M, and J.D helped in the project management.

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Correspondence to Srinath Rajeswaran.

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Rajeswaran, S., Veeraiyan, B., Saravanan, V. et al. Biogenic facile green synthesis of actinobacterium exopolysaccharide-fabricated zinc oxide nanoparticles for the diverse biomedical applications. Biomass Conv. Bioref. (2023). https://doi.org/10.1007/s13399-023-05053-4

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  • DOI: https://doi.org/10.1007/s13399-023-05053-4

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