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Antioxidant and anticancer activities of nematocyst venom protein of five scyphozoan Chrysaora jellyfish’s species from the coastal waters of Tamil Nadu, India

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Abstract 

The present study aimed to investigate the antioxidant and antiproliferative activity of partially purified venom protein extracted from five different species of Chrysaora jellyfish. The extracted venom was subjected to total protein analysis and the molecular weight was determined. The venom protein of Chrysaora fuscescens among tested exhibits free radical scavenging activity of about 77.3 and 56.5% by DPPH and ABTS, respectively. In addition, the venom protein exhibited lipid peroxidase (77.66%) and nitric oxide (72.07%) inhibition properties. Furthermore, venom protein exhibits antiproliferative activity against cancer cell lines, MCF-7 and A549, in a dose-dependent manner after 48 h of treatment, with IC50 values 63.70 and 44.20 µg/mL, respectively. Overall, this study demonstrates the antioxidant and antiproliferative potential of Chrysaora species venom protein and could be utilized in pharmacological industries.

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Acknowledgements

The authors are thankful to the DST-FIST (SR/FST/ESI-145/2016) for infrastructure support to carry out this work and the management of Sathyabama Institute of Science and Technology, Chennai, for their constant support in research activities.

Funding

This study was funded by the Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India, New Delhi, under the scheme of Aquaculture and Marine Biotechnology (BT/PR15485/AAQ/3/754/2015).

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Authors and Affiliations

  1. Centre for Ocean Research, MoES-Earth Science and Technology Cell (ESTC), Sathyabama Institute of Science and Technology, Chennai, 600 119, India

    S. Amreen Nisa, R. Vasantharaja & K. Govindaraju

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  1. S. Amreen Nisa
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  2. R. Vasantharaja
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  3. K. Govindaraju
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Contributions

S. Amreen Nisa: Methodology, investigation, resources. R. Vasantharaja: Formal analysis, writing — review and editing. K. Govindaraju: Conceptualization, project administration, writing — review and editing.

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Correspondence to K. Govindaraju.

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Nisa, S.A., Vasantharaja, R. & Govindaraju, K. Antioxidant and anticancer activities of nematocyst venom protein of five scyphozoan Chrysaora jellyfish’s species from the coastal waters of Tamil Nadu, India. Biomass Conv. Bioref. (2023). https://doi.org/10.1007/s13399-023-04206-9

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