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Valorization of cephalopod liver viscera for oil production: chemical characteristics, nutritional profile and pharmacological activities

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Abstract

The physical characteristics such as specific gravity, solidification point, saponification value, iodine, and acid value of liver oil were analyzed, and it has showed good characters similar to fish oil. The heavy metal was found in permissible limit, ash, and moisture was recorded in moderate level, protein, and carbohydrate were found as trace amount; the bad cholesterol was noticed lower and good cholesterol was high than fish oil. Ten fatty acids were recorded, the oleic acid, ω-3, EPA, DHA, and α- linolenic acid were recorded maximum level. The essential and non-essential amino acids were estimated and the fat soluble vitamins (A and E) were noticed higher level. The minerals Zn and Fe were found moderate level. The liver oil has showed antibacterial effect against 7 bacterial strains. The six antioxidant activities of liver oil have showed concentration depended. The Sepioteuthis lessoniana liver oil has showed against A549 cell lines.

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References

  1. Moovendhan M, Seedevi P, Shanumgam A, Vairamani S (2016) Exploration of the preventive effect of S. lessoniana liver oil on cardiac markers, hematological patterns and lysosomal hydrolases in isoproterenol-induced myocardial infarction in wistar rats: a novel report. RSC Adv 6:64147

    Google Scholar 

  2. Kimura S (1992) Wide distribution of the skin type I collagen α 3 chains in bony fish. Comp Biochem Phys 102:255–260

    Google Scholar 

  3. Shanmugam A, Ramasamy P, Mukesh Kumar B, Saravanan R, Subhapradha N, Vairamani S, Jayalakshmi K (2011) Isolation and characterization of collagen from the skin of Sepia pharaonis (Ehrenberg, 1831). Inter J Current Res 3:107–111

    Google Scholar 

  4. Takaya Y, Uchisawa H, Matsue F, Narumi J, Sasaki J, Iahada KL (1994) An investigation of the antitumour peptidoglycan fraction from the squid ink. Biol Pharm Bull 17:846–851

    Google Scholar 

  5. Rajaganapathi J, Kathiresan K, Singh TP (2000) Purification anti-HIV protein from purple fluid of the sea hare Bursatella leachiide Blainville. J Mar Biotechnol 14:447–453

    Google Scholar 

  6. Gurr MI, Harwood JL, Frayn KN (2002) Lipid biochemistry. Blackwell Science 3:1–4

    Google Scholar 

  7. Luzia AL, Sampaio GR, Castellucci CMN (2003) Torres E.A., The influence of season on the lipid profiles of five commercially important species of Brazilian fish. Food Chem 83:93–97

    Google Scholar 

  8. Dowhan W, Bogdanov K (2002) Functional roles of lipids in membranes. In: Vance DC (ed) Biochemistry of lipids, lipoproteins and membranes, 4th edn. Elsevier, Amsterdam

    Google Scholar 

  9. Anil K, Jayadeep A, Sudhakaran PR (1997) Effect of n-3 fatty acids on VLDL production by hepatocytes is mediated through prostaglandins. Biochem Mol Biol Int 43:1071–1075

    Google Scholar 

  10. Van Vlijmen BJ, Mensink RP, Vant-Hof HB, Oermans RF, Hofker MH, Havekes LM (1998) Effects of dietary fish oil on serum lipids and VLDL kinetics in hyperlipidemic apolipoprotein E3-Leiden transgenic mice. J Lipid Res 39:1181–1187

    Google Scholar 

  11. Folch J, Lees M (1957) Sloane-Stanley G.H., Simple method for isolation and purification of total lipids from animal tissues. J Biol Chem 226:497–507

    Google Scholar 

  12. Bruschweiler H, Dieffenbacher A (1991) Report on the collaborative study. Pure App Chem 63(8):1153–1163

    Google Scholar 

  13. Adeyemo FA (2004) Production, refining of Herring Fish, Chemical Engineering Department, FUT Minna

  14. Abdulkadir M, Abubakar GI, Mohammed A (2010) Production and characterization of oil from fishes. J Engg App Sci 5(7):1–5

    Google Scholar 

  15. AOAC (1984) Official methods of analysis, 11th edn. Association of Official Analytical Chemists, Washington, DC

    Google Scholar 

  16. Lowry OH, Rosenbrough NH, Farr AL, Randall RJ (1951) Protein measurements with folin phenol reagent. J Biol Chem 193:265–275

    Google Scholar 

  17. Dubois M, Giles KA, Hamilton JK, Rebors JK, Smith PA (1956) Calorimetric method for determination of sugar and related substances. Analy J Biol Chem 28:350–356

    Google Scholar 

  18. Yamamoto T, Marcouli PA, Unuma T, Akiama T (1994) Utilization of malt protein flour in fingerprinting rainbow trout diets. J Fish Sci 60:455–460

    Google Scholar 

  19. Sadasivam S, Manickam A (1996) Biochemical methods, II edition, New age international (P) Ltd, Publisher, New Delhi 179–186 pp

  20. Setti PD (1997) Qualitative analysis of drug in pharmacological formulations, 3rd edition pp589–590

  21. Farag RS, Daw ZY, Hevedi FM, El-baroty GSA (1989) Antimicrobial activity of Egyptian species essential oils. J Food Protec 52(9):665–667

    Google Scholar 

  22. Seedevi P, Moovendhan M, Sudharsan S, Vasanthkumar S, Srinivasan A, Vairamani S, Shanmugam A (2015) Structural characterization and bioactivities of sulphated polysaccharide from Monostroma oxyspermum. Int J Biol Macromol 72:1459–1465

    Google Scholar 

  23. Lee JM, Chung H, Chang PS, Lee JH (2007) Development of a method predicting the oxidative stability of edible oils using 2,2- diphenyl-1-picrylhydrazyl (DPPH). Food Chem 103(2):662–669

    Google Scholar 

  24. Halliwell B, Gutteridge JMC, Aruoma OI (1987) The deoxyribose methods: a simple ‘test tube, assay for determination of rate constants for reactions of hydroxyl radicals. Anal Biochem 165:215–219

    Google Scholar 

  25. Dinis TCP, Madeira VMC, Almeida LM (1994) Action of phenolic derivatives (acetaminophen, salicylate, and 5-amino salicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Arch Biochem Biophy 315:161–169

    Google Scholar 

  26. Freshney RI (2005) Culture of animal cell: a manual of basic technique, 5th edn. Wiley, Hoboken

    Google Scholar 

  27. Siddiqui MA, Singh G, Kashyap MP (2008) Influence of cytotoxic doses of 4-ydroxynonenal on selected neurotransmitter receptors in PC-12 cells. Toxicol In vitro 22:1681–1688

    Google Scholar 

  28. Kiruthika R (2012) Studies on the lipid composition of liver (digestive gland) oil of cuttlefish Sepia prashadi (Winckworth), MSc Thesis Bharathiar University 1–34 pp

  29. Akoh CC, Min DB (2002) Food lipids chemistry, nutrition and biotechnology. In: Shahidi F, Wanasundara PKJPD (eds) Extraction and analysis of lipids. Marcel Dekker, New York (10–1014 pp)

    Google Scholar 

  30. Young FVK (1986) The chemical and physical properties of crude fish oils for refiners and hydrogenators, International association of fish meal manufacturers. Fish Oil Bull 18:1–19

    Google Scholar 

  31. Immanuel G, Menenthira V, Palavesam A, Peter Marian M (2002) Physico-chemical properties and fatty acid profile Odonus niger liver oil. Ind J Fish 49(2):147–153

    Google Scholar 

  32. Paul DK, Rafiquel I, Sattar MA (2013) Physico-chemical studies of Lipids and Nutrient contents of Channa striatus and Channa marulius. Turk J Fish Aquat Sci 13:487–493

    Google Scholar 

  33. Rodriguez RN, de Diego SM, Beltrán S, Jaime I, Sanz MT, Rovira J (2012) Supercritical fluid extraction of fish oil from fish by-products: a comparison with other extraction methods. J Food Eng 109:238–248

    Google Scholar 

  34. Biohaz, (2010) Scientific opinion on fish oil for human consumption, food hygiene, including rancidity. EFSA J 8(10):1874–1877

    Google Scholar 

  35. Sofia V (2012) Reclamation of Loligo devauaceli (Orbigny, 1848) digestive gland (liver) waste for extraction of oil and its composition, MSc Thesis, Bharathiar University 1–39 pp

  36. Kim F, Ford I, Steg PG, Tardif JC, Tendera M, Ferrari R (2014) Ivabradine in stable coronary artery disease without clinical heart failure. New Engl J Med 371:1091–1099

    Google Scholar 

  37. Bharanai P (2012) Extraction and chemical composition of liver (digestive gland) oil from pharaoh cuttlefish Sepia pharaonis (Ehrenberg, 1831). MSc Thesis Bharathiar University 1–31 pp

  38. Gutnikov G (1995) Fatty acid profiles of lipid samples. J Chromatogr Biomed Appl 671(1–2):71–89

    Google Scholar 

  39. Joseph SM (2007) Biological effects of feeding cuttlefish liver oil to rats. PhD thesis, Mahatma Gandhi University Kerala 150 pp

  40. Kringstad H, Folkvoed S (1949) The nutritive value of cod roe and cod liver. J Nutr 79:489–502

    Google Scholar 

  41. Villanueva R, Riba J, Capillas CR, Gonzalez AV, Baeta M (2004) Amino acid composition of early stages of cephalopods and effect of amino acid dietary treatments on Octopus vulgaris paralarvae. Aquacul 242(14):455–478

    Google Scholar 

  42. Dean LM (1990) Nutrition and preparation. In: Martin RE, Flick GJ (eds) The seafood industry. Van Nostrand Reinhold, New York (225–267 pp)

    Google Scholar 

  43. Jobling M, Leknes O (2010) Cod liver oil: feed oil influences on fatty acid composition. Aquacult Inter 18:223–230

    Google Scholar 

  44. Mathew M (2010) Biochemical and pharmacological evaluation of liver oils of selected deep sea sharks and chimaeras of the Indian EEZ, PhD Thesis CUSAT 1–500 pp

  45. Chitra Som RS, Radhakrishnan CK (2011) Antibacterial activity of polyunsaturated fatty acids from Sardinella fimbriata and Sardinella longiceps. Ind J Geo Mar Sci 40(5):710–716

    Google Scholar 

  46. Vairamani S (2010) Studies on biochemical composition, polysaccharides and collagen from Sepiella inermis, PhD Thesis, Bharadhidasan University 1–185 pp

  47. Sabeena Farvin KH, Andersen LL, Nielsen HH, Jacobsen C, Jakobsen G, Johansson I, Jessen F (2014) Antioxidant activity of Cod (Gadus morhua) protein hydrolysates: In vitro assays and evaluation in 5% fish oil in-water emulsion. Food Chem 149:326–334

    Google Scholar 

  48. Sellami M, Rebah FB, Gargouri Y, Miled N (2018) Lipid composition and antioxidant activity of liver oils from ray species living in Tunisian coasts. Arab J Chem 11(2):233–239

    Google Scholar 

  49. Kilic E, Özdemir YG, Bolay H, Kelestimur H, Dalkara T (1999) Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia. J Cerebr Blood Flow Metab 19:511–516

    Google Scholar 

  50. Asnaashari M, Farhoosh R, Sharif A (2014) Antioxidant activity of gallic acid and methyl gallate in triacylglycerols of Kilka fish oil and its oil-in-water emulsion. Food Chem 159:439–444

    Google Scholar 

  51. Gordon HM (1990) The mechanism of antioxidant action in vitro. In: Hudson BKF (ed) Food antioxidant. Elsevier Applied Sciences, London (1–48 pp)

    Google Scholar 

  52. Suffness M, Pezzuto JM (1991) Methods in plant biochemistry. Academic Press San Diego l(6): 71–134 pp

  53. Xu S (1991) The methodology of the pharmacology experiments: methods of the experiments of the anticancer medicines, 2nd edn. The People’s Health Press, Beijing (1423–1458 pp)

    Google Scholar 

  54. Fang C, Granci V, Sorg O, Buchegger F, Pichard C, Marc Y, Dupertuis Y (2013) Vitamin E content in fish oil emulsion does not prevent lipoperoxidative effects on human colorectal tumors. Nutrition 29:450–456

    Google Scholar 

  55. Han SW, Sun XJ, Ritzenthaler JD (2009) Fish oil inhibits human lung carcinoma cell growth by suppressing integrin-linked kinase. Mol Cancer Res 7(1):109–117

    Google Scholar 

  56. Iagher F, de Brito Belo SR, Souza WM, Nunes JR, Naliwaiko K, Sassaki GL (2013) Antitumor and anti-cachectic effects of shark liver oil and fish oil: comparison between independent or associative chronic supplementation in Walker 256 tumor-bearing rats. Lipids Health Dis 12:146–155

    Google Scholar 

  57. Yan W, Hunt LA (2001) Interpretation of genotype X environment interaction for winter wheat yield in Ontario. Crop Sci 41:19–25

    Google Scholar 

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Acknowledgements

Authors are thankful to the Dean and Director, CAS in Marine Biology, Faculty of Marine Sciences, Annamalai University for providing all necessary facilities and the corresponding author (Dr.MM) thankful to Department of Sciences and Technology, Science and Engineering Research Board (DST-SERB), National Postdoctoral Fellowship (PDF/2017/000881), Government of India for providing financial assistance.

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Authors and Affiliations

  1. Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, 608 502, Tamil Nadu, India

    Meivelu Moovendhan, Shanmugam Vairamani & Annaian Shanmugam

  2. Bioengineering and Drug Design Laboratory, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology, Chennai, 600036, Tamil Nadu, India

    Meivelu Moovendhan

  3. Department of Civil Engineering, School of Building and Environment, Sathyabama Institute of Science and Technology, Chennai, 600119, Tamil Nadu, India

    M. Kavisri

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  1. Meivelu Moovendhan
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Meivelu Moovendhan, Kavisri, M., Vairamani, S. et al. Valorization of cephalopod liver viscera for oil production: chemical characteristics, nutritional profile and pharmacological activities. Biomass Conv. Bioref. 13, 10011–10019 (2023). https://doi.org/10.1007/s13399-021-01650-3

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