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Extension in the approaches to treat cancer through siRNA system: a beacon of hope in cancer therapy

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Abstract

Along with the evolutionary breakthrough of RNA interference and the applicability for gene knockdown, a subsequent development in siRNA-based therapeutics has been attained. The gene therapy based on RNAi is in transition progress from the research aspects to clinical base. Being a potent tool, siRNA is used as therapeutic against several disorders. Cancer which is one of the deadliest diseases is now treated with an advanced mechanism of siRNA delivery inside the genome, leading to gene silencing; thereby, blocking translation of gene to form protein. siRNA tool delivers remedial effects with the advantages of safe delivery and efficiency. Despite its merits, barriers including instability at physiological conditions, lack of ability to cross biological membranes, off-targets, and safety are also associated with siRNA delivery system. The gene silencing efficiency values both in vitro and in vivo reported in the past years have been reviewed by material type (lipid, polymer, silica, porous silicon, and metal). This review presents a deep insight in the development of targeted delivery of siRNA. Since several clinical trials have also been performed regarding the siRNA delivery against cancer, it can also be stated that the delivery system should be good enough to achieve effective siRNA drug development.

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Acknowledgements

Authors thank to Shri Guru Ram Rai University, Patel Nagar, Dehradun, Uttarakhand, India, for providing high speed Internet connectivity.

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Author notes

  1. Indra Rautela and Aditi Sharma contributed equally.

Authors and Affiliations

  1. Department of Biotechnology, School of Applied and Life Sciences (SALS), Uttaranchal University, Dehradun, 248001, Uttarakhand, India

    Indra Rautela

  2. Department of Biotechnology and Department of Life Sciences, Graphic Era Deemed to be University, Dehradun, 248002, Uttarakhand, India

    Aditi Sharma

  3. Department of Biotechnology, School of Basic and Applied Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun, 248001, Uttarakhand, India

    Pallavi Dheer & Manish Dev Sharma

  4. Department of Biochemistry, H.N.B. Garhwal (A Central) University, Srinagar, 246174, Uttarakhand, India

    Priya Thapliyal

  5. Department of Microbiology, School of Basic and Applied Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun, 248001, Uttarakhand, India

    Shweta Sahni

  6. Rani Lakshmi Bai Central Agricultural University, Jhansi, 284003, Uttar Pradesh, India

    Vimlendu Bhushan Sinha

Authors
  1. Indra Rautela
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  2. Aditi Sharma
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  3. Pallavi Dheer
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  4. Priya Thapliyal
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  5. Shweta Sahni
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  6. Vimlendu Bhushan Sinha
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  7. Manish Dev Sharma
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Contributions

Indra Rautela and Aditi Sharma carried information retrieval and compilation; Pallavi Dheer, Priya Thapliyal, and Shweta Sahni made first draft of the manuscript; Vimlendu Bhushan Sinha critically reviewed the manuscript and finalized the manuscript in current form; Manish Dev Sharma conceptualized, supervised, and finalized the manuscript for publication.

Corresponding author

Correspondence to Manish Dev Sharma.

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Rautela, I., Sharma, A., Dheer, P. et al. Extension in the approaches to treat cancer through siRNA system: a beacon of hope in cancer therapy. Drug Deliv. and Transl. Res. 12, 1002–1016 (2022). https://doi.org/10.1007/s13346-021-00995-6

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  • DOI: https://doi.org/10.1007/s13346-021-00995-6

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