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Pluronic-F127 composite film loaded with erythromycin for wound application: formulation, physicomechanical and in vitro evaluations

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Abstract

Composite film dressings composed of pluronic F127 (PL)–pectin (PC) and pluronic (PL) F127–gelatin (GL) were investigated as potential drug delivery system for wound healing. Composite films were solvent cast by blending PL with PC or GL in different ratios using glycerol (2.5%) as plasticizer. Erythromycin (ER) (0.1%) was incorporated in films as model hydrophobic antibiotic. The optimized composite films were characterized for physical appearance, morphology, mechanical profile, and thermal behavior. In addition, drug release, antibacterial activity, and cytocompatibility of the films were investigated to assess their potential as drug delivery system. The composite films exhibited excellent wound dressing characters in terms of appearance, stability, and mechanical profile. Moreover, ER-loaded composite films released ER in controlled manner, exhibited antibacterial activity against Staphylococcus aureus, and were non-toxic to human skin fibroblast. These findings demonstrate that these composite films hold the potential to be formulated as antibacterial wound dressing.

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Funding

The authors would like to thank Universiti Kebangsaan Malaysia (UKM) for the research grants (Grant no. GP-K016155) and facility support.

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Authors and Affiliations

  1. Centre of Drug Delivery Research, Faculty of Pharmacy, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

    Taradokht Alavi, Masoud Rezvanian, Najwa Mohamad & Shiow-Fern Ng

  2. Department of Pharmaceutics, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran

    Taradokht Alavi & Masoud Rezvanian

  3. Department of Pharmacy, Forman Christian College (A Chartered University), Ferozepur Road, Lahore, 54600, Pakistan

    Naveed Ahmad

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  1. Taradokht Alavi
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Correspondence to Shiow-Fern Ng.

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Alavi, T., Rezvanian, M., Ahmad, N. et al. Pluronic-F127 composite film loaded with erythromycin for wound application: formulation, physicomechanical and in vitro evaluations. Drug Deliv. and Transl. Res. 9, 508–519 (2019). https://doi.org/10.1007/s13346-017-0450-z

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