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Correlation of Transient Elastography With MRI T2* and Serum Ferritin Levels in Children With Transfusion-Dependent Thalassemia

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Abstract

Objectives

We investigated the correlation of transient elastography (TE) with MRI R2* values and serum ferritin in patients with transfusion-dependent thalassemia (TDT)

Methods

We reviewed hospital records of 59 patients with TDT aged ≥8 years without any evidence of chronic liver disease and who had fibroscan within 3 months of MRI T2*, who seen at our center between January, 2014 and December, 2019. Spearman correlation and linear regression analysis were used to evaluate the correlation between TE liver stiffness measurements and R2* MRI values and with serum ferritin.

Results

Mean (SD) age of the subjects was 13.0 (3.1) years and body mass index was 16.6 (2.3) kg/m2. Mean liver stiffness measurement, MRI T2*(3T), corresponding MRI R2*(3T), and ferritin values were 6.55 (3.10) kPa, 3.4 (4.6) milliseconds, 616.20 (383.9) Hz, and 2874.69 (1570.7) ng/mL, respectively. TE measurements correlated with MRI R2* values (r=0.61; P=0.001) and with serum ferritin level (r=0.59, P=0.001).

Conclusion

TE is a reliable tool to estimate hepatic iron overload in patients with TDT.

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Authors and Affiliations

  1. Division of Pediatric Hematology, Department of Pediatrics, Kalawati Saran Children Hospital, New Delhi, India

    Nupur Parakh & Jagdish Chandra

  2. B-52, Ashoka Niketan, Opposite Vigyan Vihar, IP Extension II, Delhi, 110 092, India

    Nupur Parakh

Authors
  1. Nupur Parakh
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  2. Jagdish Chandra
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Contributions

Both authors have contributed, designed and approved the study and are accountable for all aspects related to the study.

Corresponding author

Correspondence to Nupur Parakh.

Ethics declarations

Institutional Ethics Committee, Kalawati Saran Children’s Hospital; No.LHMC/IEC/2020/57, dated August 19, 2020.

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Competing interests

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Parakh, N., Chandra, J. Correlation of Transient Elastography With MRI T2* and Serum Ferritin Levels in Children With Transfusion-Dependent Thalassemia. Indian Pediatr 59, 929–932 (2022). https://doi.org/10.1007/s13312-022-2665-4

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