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Oral Faropenem Sodium — Implications for Antimicrobial Resistance and Treatment Effectiveness

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Abstract

Rising antimicrobial resistance (AMR) is causing therapeutic failures with antibiotics. Inappropriate use is a contributing factor. One such antibiotic on the radar is faropenem, a broad spectrum antibiotic approved in 2005 in India. Recently, faropenem sodium suspension was approved for use in children. There is a potential danger of overuse due to the convenience of oral administration. Other carbapenems such as meropenem are used parenterally. Overuse of faropenem may promote cross-resistance with other carbapenems making them ineffective.

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References

  1. Dharmapalan D, Shet A, Yewale V, Sharland M. High reported rates of antimicrobial resistance in Indian Neonatal and Pediatric Blood Stream Infections. J Pediatric Infect Dis Soc. 2017; 6:e62–e68.

    Article  Google Scholar 

  2. World Health Organisation. Antiicrobial resistance. Accessed April 25, 2022. Available from: https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance

  3. ICMR. Treatment Guidelines for Antimicrobial Use in Common Syndromes. Accessed May 05, 2022. Available from: https://main.icmr.nic.in/sites/default/files/guidelines/Treatment_Guidelines_2019_Final.pdf

  4. World Health Organisation. The WHO Essential Medicines List Antibiotic Book: improving antibiotic AWaReness. Updated 1 Feb 2022. Accessed May 24, 2022. Available from: https://www.who.int/publications/m/item/the-who-essential-medicines-list-antibiotic-book-improving-antibiotic-awarenessWHO.

  5. Gandra S, Choi J, McElvania E, et al. Faropenem resistance causes in vitro cross-resistance to carbapenems in ESBL-producing Escherichia coli. Int J Antimicrob Agents. 2020;55:105902.

    Article  CAS  Google Scholar 

  6. Schurek KN, Wiebe R, Karlowsky JA, et al. Faropenem: review of a new oral penem. Expert Rev Anti Infect Ther. 2007;5: 185–98.

    Article  CAS  Google Scholar 

  7. World Health Organisation. 2021 AWaRe classification. Accessed 09 June, 2022. Available from: https://www.who.int/publications/i/item/2021-aware-classification

  8. Critchley IA, Brown SD, Traczewski MM. National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005–2006 U.S. Faropenem surveillance study. Antimicrob Agents Chemother. 2007;51:4382–89.

    Article  CAS  Google Scholar 

  9. Gandra S, Klein EY, Pant S, et al. Faropenem consumption is increasing in india, Clinical Infectious Diseases. 2016;62:1050–2.

    Article  Google Scholar 

  10. Faropenem medoxomil. A0026, BAY 56–6854, BAY 566854, faropenem daloxate, SUN 208, SUN A0026. Drugs R D. 2008; 9:115–24.

    Google Scholar 

  11. European Medicines Agency. Human regulatory. Accessed June 24, 2022. Available from: https://www.ema.europa.eu/en/human-regulatory/post-authorisation/data-medicines-iso-idmpstandards/public-data-article-57-database

  12. Central Drugs Standard Control Organisation. Recommendations of the SEC (Antimicrobial & Antiviral) made in its 103rd meeting held on 25.08.2021 at CDSCO HQ, New Delhi. Accessed on 30 May, 2022. Available from: https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadCom mitteeFiles/Recommendations%20Antimicrobial%20&%20Antiviral%2027.07.2021.pdf

  13. Sanz MG, Marta GS, Vicens D-BF, et al. The elephant in the room: could the unregulated marketing of generic faropenem sodium be contributing to penem overuse? ECCMID 2016; 9 April 2016; Amsterdam, Netherlands.

  14. Gandra S, Klein EY, Pant S, et al. Faropenem consumption is increasing in India. Clin Infect Dis. 2016;62:1050–2.

    Article  Google Scholar 

  15. Global Faropenem Sodium Market Research Report (2021 to 2026) — by Product, Type and Region. Dec 2021. Accessed June 06, 2022. Available from: https://www.globenewswire.com/news-release/2021/12/17/2354499/28124/en/Global-Faropen emSodium-Market-Research-Report-2021-to-2026-by-Product-Type-and-Region.html

  16. Tiberi S, Sanz MG, Millar M. The need for global regulation of antibiotics: The case of a generic oral penem. Clin Infect Dis. 2016;62:1466–7.

    Article  Google Scholar 

  17. Global Essential medicines. India. Accessed July 05, 2022. Available from: https://global.essentialmeds.org/dashboard/countries/56

  18. The Gazette of India: Extraordinary. Schedule H drugs, last amended vide notification number G.s.R. z2 (E), dated the 8th February, 2013, New Delhi. Accessed on 08 June, 2022. Available from: http://www.dcaodisha.nic.in/sites/default/files/Schedule%20H1%20Drugs.pdf

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Correspondence to Dhanya Dharmapalan.

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Dharmapalan, D., Chandy, S.J. Oral Faropenem Sodium — Implications for Antimicrobial Resistance and Treatment Effectiveness. Indian Pediatr 59, 879–881 (2022). https://doi.org/10.1007/s13312-022-2648-5

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