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Pulmonary Function in Children With Transfusion-Dependent Thalassemia and Its Correlation With Iron Overload

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Abstract

Objective

To assess the pulmonary function of children with transfusion-dependent thalassemia, and to correlate its pattern with serum iron status.

Methods

Cross-sectional study done in the pediatrics department of a tertiary care hospital from June, 2018 to May, 2019. 66 children aged 5–18 years with β-thalassemia and HbE/β-thalassemia, admitted for blood transfusion, and with a history of minimum 20 transfusions, were enrolled. Estimation of forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio by spirometer, estimation of serum ferritin and CRP, and chest X-rays were done in all the participants.

Results

53 (80.3%) children had HbE/β-thalassemia, and 47 (71.2%) showed restrictive pulmonary dysfunction. The mean serum ferritin with impaired pulmonary function was 5616 (70.34) ng/mL and serum ferritin level had significant correlation with pulmonary function (P<0.001).

Conclusion

Restrictive pattern of pulmonary dysfunction was common in children with thalassemia, and body iron status had a significant association with pulmonary impairment.

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Funding

Funding: None

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Authors and Affiliations

  1. Department of Paediatrics, Tezpur Medical College, Tumuki, Bihaguri, Tezpur, Sonitpur, 784 010, Assam, India

    Aditi Baruah & Jonali Bhattacharjee

Authors
  1. Aditi Baruah
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  2. Jonali Bhattacharjee
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Contributions

AB: conceptualized the study, analyzed data, reviewed literature, revised the manuscript and critically reviewed; JB: conceptualized the study, collected data, searched literature, analyzed data, drafted the manuscript. Both the authors approved the final manuscript, and are accountable for all aspects related to the study.

Corresponding author

Correspondence to Jonali Bhattacharjee.

Ethics declarations

Institutional Ethics Committee, Assam Medical College; No. ECR/636/Inst/AS/2014 dated Sep 24, 2019.

Additional information

Competing interest: None stated.

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Baruah, A., Bhattacharjee, J. Pulmonary Function in Children With Transfusion-Dependent Thalassemia and Its Correlation With Iron Overload. Indian Pediatr 59, 455–458 (2022). https://doi.org/10.1007/s13312-022-2534-1

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  • DOI: https://doi.org/10.1007/s13312-022-2534-1

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