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Brain Injury Patterns in Neonates With Hypernatremic Dehydration: Single Center Experience

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Abstract

Objective

To find out the incidence, spectrum, and topographical distribution of brain lesions in neonatal hypernatremic dehydration.

Methods

We prospectively enrolled 100 consecutive neonates admitted with hypernatremic dehydration. 93 neonates underwent magnetic resonance imaging brain to identify the nature and site of neurological injury.

Results

Neuroradiological lesions were found in 42 (45.2%) babies. Edema was the most common finding in 37 (39.8%), followed by hemorrhage in 13 (13.9%) and thrombosis in 6 (6.4%). Edema predominantly affected juxtacortical/subcortical white matter followed by periventricular white matter and centrum semiovale, posterior part of internal capsule, and basal ganglia/thalamus. Occipital horns of lateral ventricle were the main sites of hemorrhage. Thrombotic lesions predominantly involved sagittal, straight and transverse sinuses. Brain lesions were observed only in severe hypernatremia group.

Conclusion

In neonatal hypernatremic dehydration, edema was the most common neurological lesion, followed by hemorrhage and thrombosis. Subcortical/juxtacortical white matter was the most commonly affected site.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Dr SN Medical College, Jodhpur, Rajasthan, India

    Anju Meena, Anurag Singh, Vishnu Kumar Goyal & Vikas Payal

  2. Department of Neonatology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

    Neeraj Gupta

  3. Department of Radiodiagnosis, Dr SN Medical College, Jodhpur, Rajasthan, India

    Kirti Chaturvedi

Authors
  1. Anju Meena
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  2. Anurag Singh
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  3. Vishnu Kumar Goyal
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  4. Neeraj Gupta
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  5. Vikas Payal
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  6. Kirti Chaturvedi
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Corresponding author

Correspondence to Vishnu Kumar Goyal.

Additional information

Note

Additional material related to this study is available with the online version at www.indianpediatrics.net

Ethics clearance

Institutional Ethics Committee, Dr SN Medical College, Jodhpur. No. SNMC/IEC/2019/55 dated March 16, 2019.

Contributors

AM: data acquisition, and initial manuscript; AS: conception, design and manuscript revision; VKG: conception, design and intellectual content; NG: data analysis and manuscript revision; VP: conception, data interpretation, initial manuscript; KC: data interpretation, initial manuscript. All authors approved the final manuscript.

Funding

None

Competing interest

None stated.

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Meena, A., Singh, A., Goyal, V.K. et al. Brain Injury Patterns in Neonates With Hypernatremic Dehydration: Single Center Experience. Indian Pediatr 58, 947–950 (2021). https://doi.org/10.1007/s13312-021-2328-x

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  • DOI: https://doi.org/10.1007/s13312-021-2328-x

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