Abstract
Objective
To compare clinical and neurodevelopmental outcome at the age of 6 months for neonates born to SARS-CoV-2-positive mothers.
Methods
Neonates of SARS-CoV-2 positive mothers, admitted in our hospital were assessed for growth, neurodevelopment by Amiel-Tison method, and Developmental Profile (DP3) at discharge as part of another study (July 2020). This data were retrieved and babies followed-up at the age of 6 months. Composite adverse outcome was death within 6 months post discharge or DP3 score <70 and hearing/visual deficit.
Results
Out of 131 enrolled at discharge, 127 (97%) were followed up. SARS-CoV-2 positive neonates (Group I; 19, 15%) had more symptoms (P=0.012), sepsis (P=0.014), pneumonia (P=0.029), longer hospital stay (P<0.001) following birth compared to group II (SARS-CoV-2 negative neonates;108, 85%). No baby in group I met definition of composite adverse outcome, while in group II it was 0.9% (1 child with DP3 <70 with hearing deficit) (P=1.0) without any difference in hospital readmission, growth, DP3 scores, or tone abnormalities.
Conclusions
There is no difference in growth, neurodevelopment, and hospital readmission in early infancy among infected and non-infected babies born to SARS-CoV-2 positive mothers.
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Institutional Ethics Committee of Medical College Kolkata; No. MC/KOL/IEC/NON-SPON/1046/02/2021, dated February 20, 2021.
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SR: substantial contribution in acquisition, analysis of data, drafting the work; DM: substantial contribution in design of the work, interpreting the data, revising it critically for important intellectual content; RD: substantial contribution in acquisition of data, interpretation of results and critical revision of the work; AH: substantial contribution in conception, analysis of data, critical revision of the work. All authors approved the final version to be published.
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Munian, D., Das, R., Hazra, A. et al. Outcome of Neonates Born to COVID-Positive Women at 6 Months of Age. Indian Pediatr 58, 853–856 (2021). https://doi.org/10.1007/s13312-021-2308-1
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DOI: https://doi.org/10.1007/s13312-021-2308-1