Abstract
Background
Cooked green banana (Musa paradisiaca) has been observed to be useful in reducing the duration of diarrheal illness in children.
Objective
To evaluate whether supplementation of cooked green banana shortens the duration of diarrhea in children with acute watery diarrhea with no dehydration.
Study design
Open label randomized controlled trial.
Participants
Consecutive children aged 9 months to 5 years who presented with acute watery diarrhea within 48 hours of onset of illness with no dehydration.
Intervention
Children in the control group received standard care, while those in the intervention group received cooked green banana in addition to standard care under supervision in the hospital for 72 hours, and then continued at home until diarrhea stopped or 14th day of illness, whichever is earlier.
Outcome measures
Proportion of children who improved at 72 hours of intervention (passing formed stools with normal frequency) was considered as the primary outcome and the incidence of complications such as dehydration, persistent diarrhea and secondary lactose intolerance were evaluated as the secondary outcomes.
Results
The proportion of children who recovered within 72 hours was significantly higher (62.4%) in the green banana group compared to the control group (47.2%) [RR 1.3 (95% CI 1.05–1.7), NNT=7]. The number of children with complications such as dehydration and persistent diarrhea was also signi-ficantly less in the intervention group.
Conclusion
Supplementation of cooked green banana in the diet of children with acute watery diarrhea with no dehydration hastens their recovery.
Similar content being viewed by others
References
Key facts on Diarrhoeal disease. Available from: https://www.who.int/en/news-room/fact-sheets/detail/diarrhoeal-disease. Accessed June 11, 2020.
GBD 2016 Diarrheal Disease Collaborators. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhea in 195 countries: A systematic analysis for the global burden of disease study 2016. Lancet Infect Dis. 2018;18:1211–28.
World Health Organization. The treatment of Diarrhea: A manual for Physicians and Other Senior Health Workers, 4th rev. Available from: https://apps.who.int/iris/handle/10665/43209. Accessed June 11, 2020.
Rabbani GH, Larson CP, Islam R, Saha UR, Kabir A. Green banana-supplemented diet in the home management of acute and prolonged diarrhoea in children: A community-based trial in rural Bangladesh. Trop Med Int Health. 2010;15:1132–9.
Rabbani GH, Teka T, Zaman B, Majid N, Khatun M, Fuchs GJ. Clinical studies in persistent diarrhea: Dietary management with green banana or pectin in Bangladeshi children. Gastroenterology. 2001;121:554–60.
Rabbani GH, Teka T, Kumar Saha S, et al. Green banana and Pectin improve small intestinal permeability and reduce fluid loss in Bangladeshi children with persistent diarrhea. Dig Dis Sci. 2004;49:475–84.
World Health Organization. Training Course on Child Growth Assessment. Geneva, WHO, 2008. Available from: https://www.who.int/childgrowth/training/module_h_directors_guide.pdf. Accessed June 11, 2020.
Moore SR, Lima NL, Soares AM, et al. Prolonged episodes of acute diarrhea reduce growth and increase risk of persistent diarrhea in children. Gastroenterology. 2010;139:1156–64.
Faisant N, Gallant DJ, Bouchet B, Champ M. Banana starch breakdown in the human small intestine studied by electron microscopy. Eur J Clin Nutr. 1995;49:98–104.
Topping DL. Short chain fatty acids produced by intestinal bacteria. Asia Pac J Clin Nutr. 1996;5:15–19.
Yan H, Ajuwon KM. Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. PLoS One. 2017;12:e0179586.
D’Argenio G, Cosenza V, Sorrentini I, et al. Butyrate, mesalamine, and factor XIII in experimental colitis in the rat: Effects on transglutaminase activity. Gastroenterology. 1994;106:399–404.
Frankel WL, Zhang W, Singh A, Klurfeld DM, Don S, Sakata T, et al. Mediation of trophic effects of short-chain fatty acids on the rat jejunum and colon. Gastroenterology. 1994;106:375–80.
Sandle GI. Salt and water absorption in the human colon: a modern appraisal. Gut. 1998;43:294–9.
Parada Venegas D, De la Fuente MK, Landskron G, et al. Short chain fatty Acids (SCFAs)-mediated gut epithelial and immune regula-tion and its relevance for inflammatory bowel diseases. Front Immunol. 2019;10:277.
Fagbemi JF, Ugoji E, Adenipekun T, Adelowaotan O. Evaluation of the antimicrobial properties of unripe banana (Musa sapientum L), lemon grass (Cympobogan citrates S.) and turmeric (Curcuma longa L.) on pathogens. Afr J Biotechnol. 2009;8:1176–82.
Rabbani GH, Albert MJ, Hamidur Rahman AS, Moyenul Isalm M, Nasirul Islam KM, Alam K. Short-chain fatty acids improve clinical, pathologic, and microbiologic features of experimental shigellosis. J Infect. 1999;179:390–7.
Mura Paroche M, Caton SJ, Vereijken MJLC, Weenen H, Houston-Price C. How infants and young children learn about food: A systematic review. Front Psychol. 2017;8: 1046.
Bhatawale SP, Mohammad UIA, Mirza RSS, Mohammed Zafar IM, Siddiqui AN, Fatema M. Effect of unripe banana flour incorporation on resistance starch content of rice papad. J Nutr Food Sci. 2012;2:143.
Author information
Authors and Affiliations
Corresponding author
Additional information
Ethical clearance
Institutional ethics committee of MGMCRI, Puducherry; ECR/451/Inst/PO/2013/RR-16 dated 08/06/2016.
Contributors
DG, AC: conceptualized, designed the study and finalized the manuscript; KK, BB, PJ, PS: collected, compiled the data and helped in analyzing and drafting the manuscript. All have approved the final draft.
Funding
None
Competing interests
None stated.
Rights and permissions
About this article
Cite this article
Gunasekaran, D., Chandramohan, A., Karthikeyan, K. et al. Effect of Green Banana (Musa paradisiaca) on Recovery in Children With Acute Watery Diarrhea With No Dehydration: A Randomized Controlled Trial. Indian Pediatr 57, 1114–1118 (2020). https://doi.org/10.1007/s13312-020-2063-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13312-020-2063-8