Abstract
Objective
We evaluated the activity of autonomic nervous system in children with celiac disease by using heart rate variability (HRV) analysis.
Methods
HRV parameters of 37 children with celiac disease were compared to 36 age- and sex-matched healthy controls. None of the participants had a systemic, central or peripheral neurological disease.
Results
Statistically significant differences were present in two parameters; standard deviation of all RR intervals (SDNN) and standard deviation of 5-minute RR interval means (SDANN). Age was negatively correlated with mean, minimum and maximum heart rate. Duration of disease was positively correlated with low frequency power-high frequency power ratio. No correlation was found between anti-tissue transglutaminase IgA level and HRV parameters.
Conclusion
Celiac disease may affect autonomic nervous function in children even if there are no symptoms of dysautonomia.
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Contributions: SK: idea, concept, design, control, supervision and critical review; SK,SS: data Collection and/or Processing, analysis and/or interpretation; literature review: writing the article, materials and references and finding.
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Ethical clearance: Local ethics committee of Health Sciences University, Kecioren Training and Research Hospital; No. 15/1864 dated March 03, 2019.
Competing interest: None stated.
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Kayali, S., Selbuz, S. Assessment of Autonomic Nervous System in Children with Celiac Disease: A Heart Rate Variability Study. Indian Pediatr 57, 719–722 (2020). https://doi.org/10.1007/s13312-020-1915-6
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DOI: https://doi.org/10.1007/s13312-020-1915-6